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| 1 | Affinity peptide developed by phage display selection for targeting gastric cancer显示文摘AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy. | Wen-Jie Zhang Yan-Xia Sui Arun Budha Jian-Bao Zheng Xue-Jun Sun Ying-Chun Hou Thomas D Wang Shao-Ying Lu | 2012 | World Journal of Gastroenterology2012，18，17： | 12 |
| 2 | Carcinoma of the gallbladder显示文摘 | Sanjeev Misra Arun Chaturvedi Naresh C Misra Indra D Sharma | 2003 | Lancet Oncology2003，，3： | 2 |
| 3 | Extraction of peroxi- dase from waste Brassica aleraeea used for the treatment of aqueous phenol in synthetic waste water显示文摘 | Ashutash N D Arun C Arthanareeswaran g | 2014 | Journal of Environmental Chemical Engi ng2014，2，2： | 1 |
| 4 | Least-squares fitting of two 3-D point sets显示文摘 | ARUN K S HUANG T S BLOSTEIN S D | 1987 | IEEE Trans Pattern Anal Machine Intell1987，9，： | 1 |
| 5 | Phosphate solubilizing bacteria from subtropical soil and their tricalcium phosphate solubilizing abilities显示文摘 | CHEN Y P REKHA P D ARUN A B | 2006 | Applied Soil Ecology2006，34，1： | 1 |
| 6 | Phosphate solubilizing bacteria from subtropical soil and their tricalcium phosphate solubilizing abilities显示文摘 | Chen Y P Rekha P D Arun A B | 2006 | Applied Soil Ecology2006，34，1： | 1 |
| 7 | the basic and applied aspects of superoxide dismutase显示文摘 | Amit B Som D Arun K | 2011 | Journal of Molecular Catalysis B:Enzymatic2011，68，3： | 1 |
| 8 | Least-squares fitting of two 3-D point sets显示文摘 | ARUN K S HUANG T S BLOSTEIN S D | 1987 | IEEE Trans Pattern Anal Mach Intell1987，9，9： | 1 |
| 9 | Least-squares fitting of two 3-D point sets显示文摘 | ARUN K S HUANG T S BLOSTEIN S D | 1987 | IEEE Transactions on Pattern Analysis and Machine Intelligence1987，9，5： | 1 |
| 10 | Direct electron transfer with yeast cells and construction of a mediatorless microbial fuel cell 显示文摘 | Prasad D Arun S Murugesan M | 2007 | Biosensors and Bio- electronics2007，12，： | 1 |
| 11 | Least-squares fitting of two 3-D point sets显示文摘 | Arun K S Huang T S Blostein S D | 1987 | IEEE Transactions on Pattern Analysis and Machine Intelligence1987，9，5： | 1 |
| 12 | N-gram a;naJysis for computer virus detection显示文摘 | D K rishna Sa deep Reddy Arun K Pujari | 2006 | Comput Virol2006，，： | 1 |
| 13 | Least-squares fitting of two3-D point sets显示文摘 | Arun K S Huang T S Blostein S D | 1987 | IEEE Transactions on Pattern Analysisand Machine Intelligence1987，，5： | 1 |
| 14 | Three dimensional finite element analysis of stress distribution around implant with straight and angled abutments in different bone qualities 显示文摘 | Arun Kumar G Mahesh B George D | 2013 | - J Indian Prosthodont Soc2013，13，4： | 1 |
| 15 | Near-infrared flourescent probes:synthesis and spectroscopic investigation of a few amphiphilic squaraine dyes 显示文摘 | Arun T K Ramaiah D | 2005 | Journal of Physical and Chemistry : A2005，109，25： | 1 |
| 16 | Direct electron transfer with yeast cells and construction of a mediatorless microbial fuel cell 显示文摘 | Berchmans S Prasad D Arun S | 2007 | Biosensors & Bioelectronics2007，22，11： | 1 |
| 17 | Ketosis-Prone Diabetes: Dissection of a Heterogeneous Syndrome Using an Immunogenetic and β-Cell Functional Classification, Prospective Analysis, and Clinical Outcomes显示文摘 | Mario Maldonado Christiane S. Hampe Lakshmi K. Gaur Susana D’Amico Dinakar Iyer Lisa P. Hammerle Douglas Bolgiano Lucille Rodriguez Arun Rajan ?ke Lernmark Ashok Balasubramanyam | 2003 | The Journal of Clinical Endocrinology & Metabolism2003，，11： | 1 |
| 18 | Structure-based design: synthesis and biological evaluation of a series of novel cycloamide- derived HIV-1 protease inhibitors 显示文摘 | Arun K Ghosh Lisa M Swanson Hanna Cho Sofiya Leshehenko Khaja Azhar Hussain Stephanie Kay D Eric Walters Yasuhiro Koh Hiroaki Mitsuya | 2005 | Journal of medicinal chemistry2005，48，10： | 1 |
| 19 | Novel aluminium-silicon alloys for electronics packaging显示文摘 | Sangha S P S Jacobsom D M Arun J A | 1997 | Engineering Science and Education Journal1997，11，： | 1 |
| 20 | State space and SVD based approximation methods for the harmonic retrieval problem显示文摘 | Kung S Y Arun K S Rao D V B | 1983 | Journal of the Optical Society of America1983，73，12： | 1 |
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