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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
| 3 | Mechanisms of Obesity-induced Gastrointestinal Neoplasia显示文摘 | José O. Alemán Leonardo H. Eusebi Luigi Ricciardiello Kavish Patidar Arun J. Sanyal Peter R. Holt | 2013 | Gastroenterology2013，，： | 3 |
| 4 | Prevalence and clinical characteristics associated with left atrial thrombus detection: Apixaban显示文摘BACKGROUND The prevalence of left atrial appendage(LAA) thrombus detection by transesophageal echocardiogram(TEE) in patients with non-valvular atrial fibrillation(AF) anticoagulated with apixaban is not well defined and identification of additional risk factors may help guide the selection process for pre-procedural TEE. The purpose of our study was to retrospectively analyze the prevalence of LAA thrombus detection by TEE in patients continuously anticoagulated with apixaban for ≥ 4 wk and evaluate for any cardiac risk factors or echocardiographic characteristics which may serve as predictors of thrombus formation.AIM To retrospectively analyze the prevalence of LAA thrombus detection by TEE in patients continuously anticoagulated with apixaban.METHODS Clinical and echocardiographic data for 820 consecutive patients with AF undergoing TEE at Augusta University Medical Center over a four-year period were retrospectively analyzed. All patients(apixaban: 226) with non-valvular AF and documented compliance with apixaban for ≥ 4 wk prior to index TEE were included.RESULTS Following ≥ 4 wk of continuous anticoagulation with apixaban, the prevalence ofLAA thrombus and LAA thrombus/dense spontaneous echocardiographic contrast was 3.1% and 6.6%, respectively. Persistent AF, left ventricular ejection fraction < 30%, severe LA dilation, and reduced LAA velocity were associated with thrombus formation. Following multivariate logistic regression, persistent AF(OR: 7.427; 95%CI: 1.02 to 53.92; P = 0.0474), and reduced LAA velocity(OR:1.086; 95%CI: 1.010 to 1.187; P = 0.0489) were identified as independent predictors of LAA thrombus. No Thrombi were detected in patients with a CHA2 DS2-VASc score ≤ 1.CONCLUSION Among patients with non-valvular AF and ≥ 4 wk of anticoagulation with apixaban, the prevalence of LAA thrombus detected by TEE was 3.1%. This suggests that continuous therapy with apixaban does not completely eliminate the risk of LAA thrombus and that TEE prior to cardioversion or catheter ablation may be of benefit in patients with multiple risk factors. | Hoyle L Whiteside Arun Nagabandi Kristen Brown Deepak N Ayyala Gyanendra K Sharma | 2019 | World Journal of Cardiology2019，11，2： | 2 |
| 5 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
| 6 | Extraction of peroxi- dase from waste Brassica aleraeea used for the treatment of aqueous phenol in synthetic waste water显示文摘 | Ashutash N D Arun C Arthanareeswaran g | 2014 | Journal of Environmental Chemical Engi ng2014，2，2： | 1 |
| 7 | Sheth Web- based marketing- The coming revolution in marketing thought and strategy 显示文摘 | Arun Sharma Jagdish N | 2004 | Journal of Business Research2004，57，： | 1 |
| 8 | CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer显示文摘 | Cabioglu N Yazici M S Arun B | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 9 | Perceptions of Incompatibility in Customer-to-Customer Interactions:Examining Individual Level Differences显示文摘 | RAAJPOOT N A ARUN S | 2006 | Journal of Services Marketing2006，20，5： | 1 |
| 10 | Osmotically controlled drug delivery显示文摘 | Vishal G Verma S Arun N | 2005 | Drug Deliv Tech2005，5，7： | 1 |
| 11 | Defective N - acety- laspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease 显示文摘 | Madhavarao C N Arun P Moffett J R | 2005 | Proc Natl Acad Sci U S A2005，102，14： | 1 |
| 12 | The interaction of aspiration pneumonia with demographic and cerebrovascular disease riskfactors is predictive of discharge level of care in acute stroke patient 显示文摘 | Ife~ika-Jones NL Arun N Peng H | 2012 | Am ~ Ph3 s Med Rehabil2012，91，2： | 1 |
| 13 | CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1breast cancer显示文摘 | Cabioglu N Yazici MS Arun B | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 14 | Fluoride release capacities of four different orthodontic adhesives显示文摘 | Evrenol BI Kucukkeles N Arun T | 1999 | J Clin Pediatr Dent1999，23，： | 1 |
| 15 | CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer显示文摘 | Cabioglu N Yazici MS Arun B | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 16 | Perceptions of incompatibility in customer-to-customer interactions: examining individual level differences 显示文摘 | Raajpoot N A Arun S | 2006 | Journal of Services Marketing2006，20，5： | 1 |
| 17 | ISSLS prize winner: a study of diffusion in human lumbar discs: a serial magnetic reso nance imaging study documenting the influence of the endplate on diffusion in normal and degeneratc discs显示文摘 | Rajasekaran S Babu ]N Arun R elal | 2004 | Spine2004，29，23： | 1 |
| 18 | Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats显示文摘 | Arun N Nalini N | 2002 | Plant Foods Hum- Nutr2002，57，1： | 1 |
| 19 | Trapping heavy metals by using calcium hydroxyapatite and dielectrophoresis显示文摘 | John B Arun J K Ange N | 2007 | J Hazardous Mater A2007，139，： | 1 |
| 20 | CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer 显示文摘 | Cabioglu N Yazici M S Arun B | 2005 | Clin Cancer Res2005，11，16： | 1 |
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