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| 1 | 顺铂、异环磷酰胺和长春酰胺联合用药治疗非小细胞肺癌的Ⅱ期研究显示文摘用顺铂(CDDP,100mg/m^2)、异环磷酰胺(IFX,2g/m^2×3,合并Mcsna)和长春酰胺(VDS,3mg/m^2)联合化疗方案(CIV)治疗47例不能手术的非小细胞肺癌。3周或5周重复一次。40例可评价的病人,19例(47.5%) 获部分缓解(PR)(其中鳞癌78.6%、腺癌30.1%),没有完全缓解(CR)病例。本方案的血液学毒性不严重,但是,肾毒性相当高,2例病人发生肾功能衰竭,随后死于全血细胞减少症和脓毒血症。作者认为,对于非小细胞肺癌,特别是鳞癌,CI方案比CDDP+VDS更有效,但是,所治疗的病人应经严格选择。 | Ryoichi Honda Akihisa Fujita YuhjiInoue Mitsuo Asakawa Akira Suzuki 刘云英 | 1992 | 癌症1992，11，3： | 14 |
| 2 | Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats显示文摘Three peptides, ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. To examine the effects of these peptides, we applied the manometric measurement of gastrointestinal motility in freely moving conscious rat models. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. Des-acyl ghrelin exerts inhibitory effects on the motility of antrum, but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state, but not in the fasted state of animals. NPY Y2 or Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptors in the brain mediate the action of des-acy ghrelin, whereas CRF type 1 and type 2 receptors in the brain mediate the action of obestatin. Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin. | Mineko Fujimiya Akihiro Asakawa Koji Ataka Ikuo Kato Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 12 |
| 3 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 4 | Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice显示文摘The cancer-associated anorexia-cachexia syndrome is observed in 80% of patients with advanced-stage cancer, and is one of the major obstacles in chemo- therapy. Ghrelin is a orexigenic hormone that has been proposed to prevent anorexia. Aim of the study was to determine whether the addition of the ghrelin agonist growth hormone releasing peptide 2 (GHRP-2) to cytotoxic therapy with 5-fluoruracil (5-FU) prevents the anorexia associated with chemotherapy in cancer cachectic mice. Thirty-three BALB/c female tumourbearing mice were randomized to receive a solution containing: (a) placebo; (b) GHRP-2; (c) 5-FU; or (d) 5-FU + GHRP-2. Ten BALB/c no tumour-bearing mice received placebo solution. Food intake and survival were checked. Six hours after the drug injection the cumulative food intake was signifi cantly increased in mice treated with the combination of 5-FU + GHRP-2 versus the 5-FU alone (P = 0.0096). On day 3, the cumulative food intake of mice treated with GHRP-2,5-FU and 5-FU + GHRP-2 signifi cantly increased com- pared with naive and vehicle groups (P = 0.0007, P = 0.0038 and P = 0.0166, respectively). The median survival time was longer in 5-FU + GHRP-2 treated mice than in those with 5-FU, although it was not signifi cant (18 d versus 15.5 d, P = 0.7). For the fi rst time, we demonstrated that the addition of GHRP-2 to cytotoxic therapy with 5-FU improved appetite in tumour-bearing mice with anorexia/cachexia syndrome in early stage. These data suggest that GHRP-2 may improve the effi cacy of therapy and the quality of life of cancer patients thank to the amelioration of their nutritional state. | Simona Perboni Cyril Bowers Shinya Kojima Akihiro Asakawa Akio Inui | 2008 | World Journal of Gastroenterology2008，14，41： | 8 |
| 5 | 拉丝模参数对棒材拉拔后残余应力的影响显示文摘 | Motoo Asakawa Wataru Sasaki Shunsuke Shishido 孙刘歌 | 2004 | 金属制品2004，30，B05： | 5 |
| 6 | Polymyxin B-immobilized fiber columns:A column to breathe new life into the treatment of interstitial lung disease?显示文摘Acute exacerbations of idiopathic pulmonary fibrosis(IPF) is a severe respiratory condition with high mortality rate. Direct hemoperfusion with polymyxin B-immobilized fiber columns(PMX-DHP) was originally introduced for the treatment of septic shock. Application of PMX-DHP to the treatment of acute exacerbations of IPF may improve oxygenation and survival of the patients with the disease. In addition to acute exacerbations of IPF, PMXDHP has been applied to acute respiratory failure fromvarious causes; an amyopathic dermatomyositis patient who developed rapidly progressive interstitial lung disease(ILD) with elevated anti-CADM-140/MDA5 autoantibody and a patient with severe amiodarone pulmonary toxicity. It is also demonstrated that PMX-DHP performed on the first day of steroid pulse therapy may improve the prognosis of patients with rapidly progressive ILDs in a case-control setting. PMX treatment decreases not only various circulating molecules but also inflammatory cells, in particular activated monocytes, producing such mediators. Although the incidence of acute exacerbations of IPF is too low for proper randomization, in order to test the effects of PMX-DHP on the disease, a cohort or casecontrol analytic study needs to be conducted, preferably from more than one center or research group. | Katsuaki Asakawa Toshinori Takada | 2015 | World Journal of Respirology2015，5，1： | 2 |
| 7 | Molecular cloning and characterization of DMRT genes from the medaka Oryzias latipes and the platyfish Xiphophorus maculatus显示文摘 | Mariko Kondo Alexander Froschauer Akiko Kitano Indrajit Nanda Ute Hornung Jean-Nicolas Volff Shuichi Asakawa Hiroshi Mitani Kiyoshi Naruse Minoru Tanaka Michael Schmid Nobuyoshi Shimizu Manfred Schartl Akihiro Shima | 2002 | Gene2002，，2： | 2 |
| 8 | Stimulation of leptin secretion by insulin显示文摘 | Minglun Tsai Akihiro Asakawa Haruka Amitani Akio Inui | 2012 | Indian Journal of Endocrinology and Metabolism2012，，9： | 2 |
| 9 | Long-term submergence of non-methanogenic oxic upland field soils helps to develop the methanogenic archaeal community as revealed by pot and field experiments显示文摘The community structure of methanogenic archaea is relatively stable,i.e.,it is sustained at a high abundance with minimal changes in composition,in paddy field soils irrespective of submergence and drainage.In contrast,the abundance in non-methanogenic oxic soils is much lower than that in paddy field soils.This study aimed to describe methanogenic archaeal community development following the long-term submergence of non-methanogenic oxic upland field soils in pot and field experiments.In the pot experiment,a soil sample obtained from an upland field was incubated under submerged conditions for 275 d.Soil samples periodically collected were subjected to culture-dependent most probable number(MPN)enumeration,polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)analysis of archaeal 16 S r RNA gene,and quantitative PCR analysis of the methyl-coenzyme M reductase alpha subunit gene(mcr A)of methanogenic archaea.The abundance of methanogenic archaea increased from 102 to 103 cells g-1 dry soil and 104 to 107 copies of mcr A gene g-1 dry soil after submergence.Although no methanogenic archaeon was detected prior to incubation by the DGGE analysis,members from Methanocellales,Methanosarcinaceae,and Methanosaetaceae proliferated in the soils,and the community structure was relatively stable once established.In the field experiment,the number of viable methanogenic archaea in a rice paddy field converted from meadow(reclaimed paddy field)was monitored by MPN enumeration over five annual cycles of field operations.Viability was also determined simultaneously in a paddy field where the plow layer soil from a farmer’s paddy field was dressed onto the meadow(dressed paddy field)and an upland crop field converted from the meadow(reclaimed upland field).The number of viable methanogenic archaea in the reclaimed paddy field was below the detection limit before the first cultivation of rice and in the reclaimed upland field.Then,the number gradually increased over five years and finally reached 103–104 cells g-1 dry soil,which was comparable to that in the dressed paddy field.These findings showed that the low abundance of autochthonous methanogenic archaea in the non-methanogenic oxic upland field soils steadily proliferated,and the community structure was developed following repeated and long-term submergence.These results suggest that habitats suitable for methanogenic archaea were established in soil following repeated and long-term submergence. | Takeshi WATANABE Susumu ASAKAWA Koichi HAYANO | 2020 | Pedosphere2020，30，1： | 2 |
| 10 | Silicon photonics for telecom and data‐com applications显示文摘In recent decades,silicon photonics has attracted much attention in telecom and data-com areas.Constituted of high refractive-index contrast waveguides on silicon-on-insulator(SOI),a variety of integrated photonic passive and active devices have been implemented supported by excellent optical properties of silicon in the mid-infrared spectrum.The main advantage of the silicon photonics is the ability to use complementary metal oxide semiconductor(CMOS)process-compatible fabrication technologies,resulting in high-volume production at low cost.On the other hand,explosively growing traffic in the telecom,data center and high-performance computer demands the data flow to have high speed,wide bandwidth,low cost,and high energy-efficiency,as well as the photonics and electronics to be integrated for ultra-fast data transfer in networks.In practical applications,silicon photonics started with optical interconnect transceivers in the data-com first,and has been now extended to innovative applications such as multi-port optical switches in the telecom network node and integrated optical phased arrays(OPAs)in light detection and ranging(LiDAR).This paper overviews the progresses of silicon photonics from four points reflecting the recent advances mentioned above.CMOS-based silicon photonic platform technologies,applications to optical transceiver in the data-com network,applications to multi-port optical switches in the telecom network and applications to OPA in LiDAR system. | Kiyoshi Asakawa Yoshimasa Sugimoto Shigeru Nakamura | 2020 | Opto-Electronic Advances2020，3，10： | 2 |
| 11 | Chemical constituents of the hepaticae 显示文摘 | ASAKAWA Y | 1982 | Fortschr Chem Org Naturst1982，42，： | 2 |
| 12 | Chemical constituents of bryophytes 显示文摘 | ASAKAWA Y | 1994 | Progress of Phytochemistry1994，65，： | 2 |
| 13 | Thiobarbituric acid test for detecting lipid peroxides显示文摘 | T. Asakawa S. Matsushita | | Lipids0，，： | 2 |
| 14 | A role for IL-27 in early regulation of Th1 differentiation显示文摘 | Owaki T Asakawa M Morishima N | | 0，，04： | 2 |
| 15 | Effects of long-term ingestion of difructose anhydride HI (DFA III ) on intestinal bacteria and bile acid metabolism in humans 显示文摘 | Kimiko Minamida Chikako Asakawa Nengah Sujaya I | 2006 | Journal of Bioscience and Bioengineering2006，101，： | 1 |
| 16 | Boma disease virus in Raccoons ( Procyon lotor ) in Japan 显示文摘 | HAGIWARA K MATOBA Y ASAKAWA M | 2009 | J Vet Med Sci2009，71，8： | 1 |
| 17 | Imaging diagnosisNeuronal ceroid lipofuscinosis with a chronic subdural hematoma显示文摘 | Asakawa MG MacLillop E Olby NJ | 2010 | Vet Radiol Ultrasound2010，51，2： | 1 |
| 18 | Carbon and nitrogen dynamics in ageing earthworm casts in grasslands of the eastern plains of Colombia 显示文摘 | DECAENS T RANGEL A F ASAKAWA N THOMAS R J | 1999 | Biology and Fertility of Soils1999，30，1： | 1 |
| 19 | Laparoscopic excision of myomet rial adenomyomas in patient s wit h adenomyosis uteri and main symptoms of severe dysme norrhea and hypermenorrhea显示文摘 | Morita M Asakawa Y Nakakuma M | 2004 | J Am Assoc Gynecol Laparosc2004，11，1： | 1 |
| 20 | Waterborne fluo-ropolymers for paint use 显示文摘 | Asakawa A Unoki M Hirono T | 2000 | Journal of Fluorine Chemistry2000，104，： | 1 |
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