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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Liver transplantation in patients with portal vein thrombosis显示文摘 | Gerardo Manzanet Fernando Sanjuán Paco Orbis Rafael López ángel Moya Manuel Juan Juanjo Vila Josep Asensi Pedro Sendra José Ru??z Mart??n Prieto José Mir | 2001 | Liver Transplantation2001，，2： | 1 |
| 3 | Six years of experience with the use of room air for the resuscitation of asphyxiatednewly born tern infants显示文摘 | Vento M Asensi M Sastre J | 2001 | Biol Neonate2001，79，34： | 1 |
| 4 | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development显示文摘 | Martin G Asensi V Montes AH | 2014 | Nitric Oxide2014，42，： | 1 |
| 5 | Bron- chodilator test:is 9% of the predicted value the same as 12% of the initial value显示文摘 | L6pez Neyra A Villa Asensi JR Gimeno Diaz de Atauri A | 2009 | An Pediatr(Barc)2009，70，5： | 1 |
| 6 | Multidrug-resis- tant acinetobacter meningitis in neurosurgical patients with intraventricular catheters:Assessment of different treatments 显示文摘 | Guardado AR Blanco A Asensi V | 2008 | Antimicrob Chemother2008，61，4： | 1 |
| 7 | Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters:assessment of different treatments显示文摘 | Rodríguez Guardado A Blanco A Asensi V | | 0，，04： | 1 |
| 8 | Sex differences in the clinical,immunological and virological parameters of HIV-infected patients treated with HAART显示文摘 | Collazos J Asensi V Carton JA | 2007 | AIDS2007，21，7： | 1 |
| 9 | Multidrug-resistant Acineto- bacter meningitis in neurosurgical patients with intraventrieular cathe- ters : assessment of different treatments 显示文摘 | Rodriguez GA Blanco A Asensi V | 2008 | J Antimicrob Chemuther2008，61，4： | 1 |
| 10 | Mul- tidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters : assessment of dif- ferent treatments显示文摘 | Rodriguez Guardado A Blanco A Asensi V | 2008 | J Antimicrob Chemother2008，61，4： | 1 |
| 11 | Skeletal isomerization of 1-butene on MCM-22 zeolite catalysts显示文摘 | MARTINEZ A | 1996 | J Catal1996，158，2： | 1 |
| 12 | Homotypic pro- tection against rotavirus-induced diarrhea in infant mice breast-fed by dams immunized with the recombinant VP8* subunit of the VP4 capsid protein 显示文摘 | Gil M T De Souza C O Asensi M | 2000 | Viral Im- munol2000，13，2： | 1 |
| 13 | Mixed unilateral transposition of a maxillary, canine, central incisor , and lateral incisor显示文摘 | Asensi JC | 2010 | Am J Orthod Dentnfacial Orthop2010，137，4： | 1 |
| 14 | Xanthine oxidase is involved in free radical production in type ldiabetes: protection by allopurinol显示文摘 | Desco Asensi Marquez | 2002 | Diabetes2002，51，4： | 1 |
| 15 | Mero- penem monotherapy is as effective as and safter than imi- penem to treat brain abscesses 显示文摘 | Martin Canal G Saavedra A Asensi J M | 2010 | Int J Antimicrob A- gents2010，35，3： | 1 |
| 16 | Muhidrug-resistant Acinetobacter meningitis in neurosurgical patients withintraventricular catheters: assessment of difierenttreatments显示文摘 | Rodriguez Guardado A Blanco A Asensi V | 2008 | JAntimicrobChemother2008，61，4： | 1 |
| 17 | Usefulness of the brouillette index in the diagnosis of obstructive sleep apnea syndrome in children显示文摘 | Villa Asensi J De Miguel Diez J Romero Andujar F | 2000 | An Esp Pediatr2000，53，6： | 1 |
| 18 | Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma显示文摘 | Ferrer P Asensi M Segarra R | 2005 | Neoplasia2005，7，1： | 1 |
| 19 | Clonality and antimicrobial resistance gene profiles of multi- drug-resistant Salmonella enterica serovar, infantis isolates from four public hospitals in Rio de Janeiro, Brazil显示文摘 | FONSECA E L MYKYTCZUK O L ASENSI M D | 2006 | J Clin Microbio12006，44，8： | 1 |
| 20 | The chemical form and physiological function of nickel in some Iberian Alyssum species显示文摘 | Brooks R R Shaw S Asensi Marfil A | 1981 | Physiologia Plantarum1981，51，2： | 1 |
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