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| 1 | Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)显示文摘 | Judith Gault Misi Robinson Ralph Berger Carla Drebing Judith Logel Jan Hopkins Ted Moore Suzette Jacobs Jennifer Meriwether Mun Jun Choi Eun Jung Kim Katy Walton Karin Buiting Ashley Davis Charles Breese Robert Freedman Sherry Leonard | 1998 | Genomics1998，，2： | 1 |
| 2 | Preoperative Diabetes Mellitus and Long-Term Survival After Resection of Pancreatic Adenocarcinoma显示文摘 | Carrie K. Chu MD Ashley E. Mazo BS Michael Goodman MD MPH Vasili Egnatashvili MD Juan M. Sarmiento MD Charles A. Staley MD John R. Galloway MD N. Volkan Adsay MD Sol Jacobs MD David A. Kooby MD | 2010 | Annals of Surgical Oncology2010，，2： | 1 |
| 3 | Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss显示文摘 | Nathan A. Johnson Toos Sachinwalla David W. Walton Kate Smith Ashley Armstrong Martin W. Thompson Jacob George | 2009 | Hepatology2009，，4： | 1 |
| 4 | CXCR 4 antagonism attenuates load‐induced periosteal bone formation in mice显示文摘 | Philipp Leucht Sara Temiyasathit Ashley Russell Juan F. Arguello Christopher R. Jacobs Jill A. Helms Alesha B. Castillo | 2013 | J. Orthop. Res2013，，： | 1 |
| 5 | Exposure of U.S. Children to Residential Dust Lead, 1999-2004: II. The Contribution of Lead-Contaminated Dust to Children’s Blood Lead Levels显示文摘 | Dixon Sherry L Gaitens Joanna M Jacobs David E Strauss Warren Nagaraja Jyothi Pivetz Tim Wilson W Ashley Peter J | 2009 | Environmental Health Perspectives2009，，3： | 1 |
| 6 | Factors controlling nutrient availability to the developing fetus in ruminants显示文摘Inadequate delivery of nutrients results in intrauterine growth restriction(IUGR), which is a leading cause of neonatal morbidity and mortality in livestock. In ruminants, inadequate nutrition during pregnancy is often prevalent due to frequent utilization of exensive forage based grazing systems, making them highly susceptible to changes in nutrient quality and availability. Delivery of nutrients to the fetus is dependent on a number of critical factors including placental growth and development, utero-placental blood flow, nutrient availability, and placental metabolism and transport capacity. Previous findings from our laboratory and others, highlight essential roles for amino acids and their metabolites in supporting normal fetal growth and development, as well as the critical role for amino acid transporters in nutrient delivery to the fetus. The focus of this review will be on the role of maternal nutrition on placental form and function as a regulator of fetal development in ruminants. | Kathrin A Dunlap Jacob D Brown Ashley B Keith M Carey Satterfield | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 1 |
| 7 | Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart显示文摘Protein phosphatase 1 isoforms α,β,and γ(PP1α,PP1β,and PP1γ)are highly homologous in the catalytic domains but have distinct subcellular localizations.In this study,we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in the heart.In both neonatal and adult cardiac myocytes,PP1β was mainly localized in the nucleus,compared to the predominant presence of PP1α and PP1γ in the cytoplasm.Adenovirus-mediated overexpression of PP1α led to decreased phosphorylation of phospholamban,which was not influenced by overexpression of either PP1β or PP1γ.Interestingly,only cardiac-specific knockout of PP1β resulted in increased HDAC7 phosphorylation,consistent with the predominant nuclear localization of PP1β.Functionally,deletion of either PP1 isoform resulted in reduced fractional shortening in aging mice,however only PP1β deletion resulted in interstitial fibrosis in mice as early as 3 weeks of age.Deletion of neither PP1 isoform had any effect on pathological cardiac hypertrophy induced by 2 weeks of pressure overload stimulation.Together,our data suggest that PP1 isoforms have differential localizations to regulate the phosphorylation of their specific substrates for the physiological function in the heart. | Ruijie Liu Christian Miller Christiana D'Annibale Kimberly Vo Ashley Jacobs | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 0 |
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