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| 1 | Laparoscopic gastric surgery for cancer: Where do we stand?显示文摘Gastric cancer poses a significant public health problem, especially in the Far East, due to its high incidence in these areas. Surgical treatment and guidelines have been markedly different in the West, but nowadays this debate is apparently coming to an end. Laparoscopic surgery has been employed in the surgical treatment of gastric cancer for two decades now, but with controversies about the extent of resection and lymphadenectomy. Despite these difficulties, the apparent advantages of the laparoscopic approach helped its implementation in early stage and distal gastric cancer, with an increase on the uptake for distal gastrectomy for more advanced disease and total gastrectomy. Nevertheless, there is no conclusive evidence about the laparoscopic approach yet. In this review article we present and analyse the current status of laparoscopic surgery in the treatment of gastric cancer. | Pantelis T Antonakis Hutan Ashrafian Alberto Martinez Isla | 2014 | World Journal of Gastroenterology2014，20，39： | 16 |
| 2 | Pancreatic insulinomas:laparoscopic management显示文摘Insulinomas are rare pancreatic neuroendocrine tumors that are most commonly benign,solitary,and intrapancreatic. Uncontrolled insulin overproduction from the tumor produces neurological and adrenergic symptoms of hypoglycemia. Biochemical diagnosis is confirmed by the presence of Whipple's triad,along with corroborating measurements of blood glucose,insulin,proinsulin,C-peptide,β-hydroxybutyrate,and negative tests for hypoglycemic agents during a supervised fasting period. This is accompanied by accurate preoperative localization using both invasive and non-invasive imaging modalities. Following this,careful preoperative planning is required,with the ensuing procedure being preferably carried out laparoscopically. An integral part of the laparoscopic approach is the application of laparoscopic intraoperative ultrasound,which is indispensable for accurate intraoperative localization of the lesion in the pancreatic region. The extent of laparoscopic resection is dependent on preoperative and intraoperative findings,but most commonly involves tumor enucleation or distal pancreatectomy. When performed in an experienced surgical unit,laparoscopic resection is associated with minimal mortality and excellent long-term cure rates. Furthermore,this approach confers equivalent safety and efficacy rates to open resection,while improving cosmesis and reducing hospital stay. As such,laparoscopic resection should be considered in all cases of benign insulinoma where adequate surgical expertise is available. | Pantelis T Antonakis Hutan Ashrafian Alberto Martinez-Isla | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，16： | 8 |
| 3 | Use of three-dimensional printing in preoperative planning in orthopaedic trauma surgery: A systematic review and meta-analysis显示文摘BACKGROUND With the increasing complexity of surgical interventions performed in orthopaedic trauma surgery and the improving technologies used in threedimensional(3D)printing,there has been an increased interest in the concept.It has been shown that 3D models allow surgeons to better visualise anatomy,aid in planning and performing complex surgery.It is however not clear how best to utilise the technique and whether this results in better outcomes.AIM To evaluate the effect of 3D printing used in pre-operative planning in orthopaedic trauma surgery on clinical outcomes.METHODS We performed a comprehensive systematic review of the literature and a metaanalysis.Medline,Ovid and Embase were searched from inception to February 8,2018.Randomised controlled trials,case-control studies,cohort studies and case series of five patients or more were included across any area of orthopaedic trauma.The primary outcomes were operation time,intra-operative blood loss and fluoroscopy used.RESULTS Seventeen studies(922 patients)met our inclusion criteria and were reviewed.The use of 3D printing across all specialties in orthopaedic trauma surgery demonstrated an overall reduction in operation time of 19.85%[95%confidence intervals(CI):(-22.99,-16.71)],intra-operative blood loss of 25.73%[95%CI:(-31.07,-20.40)],and number of times fluoroscopy was used by 23.80%[95%CI:(-38.49,-9.10)].CONCLUSION Our results suggest that the use of 3D printing in pre-operative planning in orthopaedic trauma reduces operative time,intraoperative blood loss and the number of times fluoroscopy is used. | Catrin Morgan Chetan Khatri Sammy A Hanna Hutan Ashrafian Khaled M Sarraf | 2020 | World Journal of Orthopedics2020，11，1： | 7 |
| 4 | Single-stage laparoscopic management of acute gallstone pancreatitis:outcomes at different timings显示文摘BACKGROUND:Definitive therapy for gallstone pancreatitis requires eradication of gallstones with cholecystectomy and common bile duct(CBD) clearance.Current guidelines recommend this be done within the same admission and preferably by laparoscopic cholecystectomy and CBD exploration.We report our experience of laparoscopic single-stage management with cholecystectomy and intraoperative cholangiogram followed by laparoscopic bile duct exploration(LBDE) when necessary performed at three different stages.METHODS:From January 1998 to December 2012,134 patients(100 females and 34 males) underwent single-stage laparoscopic management of gallstone pancreatitis.Patients were classified according to the timing of surgery:'A',≤7 days from symptom onset(n=27); 'B',8 to 30 days(n=58) and 'C',>30 days(n=49).RESULTS:LBDE was performed in 30 patients with a success rate of 100%.CBD stones were found in 25 patients(A:22.2%,B:22.4%,C:12.2%).CBD stones were more common in patients undergoing surgery within 30 days of presentation than after this time point(P=0.35).Multiple choledocholithiasis was more frequent in patients treated within 7 days(P=0.04).The 30-day mortality after surgery was 0,with no conversion to an open approach.Overall complication rate was 11.9%,which did not differ significantly between patients treated within 7 days or after this time point(P=0.83).CONCLUSIONS:This study demonstrated the feasibility and reproducibility of single-stage laparoscopic management of acute gallstone pancreatitis,which has a low complication rate at any stage.Patients undergoing early treatment have a higher incidence of choledocholithiasis and multiple stones than those treated after 30 days,supporting the passage of stones with time. | Antonio Navarro-Sanchez Hutan Ashrafian Aggelos Laliotis Kamran Qurashi Alberto Martinez-Isla | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 5 |
| 5 | Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy显示文摘 | Khalid Abozguia Perry Elliott William McKenna Thanh Trung Phan Ganesh Nallur-Shivu Ibrar Ahmed Abdul R. Maher Kulvinder Kaur Jenny Taylor Anke Henning Houman Ashrafian Hugh Watkins Michael Frenneaux | 2010 | Circulation2010，，16： | 2 |
| 6 | Metabolic mechanisms in heart failure显示文摘 | Ashrafian H Frenneaux MP Opie LH | 2007 | Circulation2007，116，4： | 1 |
| 7 | Glucose-insulin-potassiumreduces the incidence of low cardiac output episodes after aorticvalve replacement for aortic stenosis in patients with left ventricularhypertrophy:results from the Hypertrophy,Insulin,Glucose,andElectrolytes(HINGE)trial显示文摘 | Howell NJ Ashrafian H Drury NE | 2011 | Circulation2011，123，2： | 1 |
| 8 | Robotic cardiac surgery: advanced minimally invasive technology hindered by barriers to adoption 显示文摘 | Athanasiou T Ashrafian H Rowland SP | 2011 | Future Cardiol2011，7，4： | 1 |
| 9 | The natriuretic peptides and their role in disorders of right heart dysfunction and pulmonary hypertension显示文摘 | Yap LB Ashrafian H Mukerjee D | 2004 | Clin Biochem2004，37，10： | 1 |
| 10 | Metabolic mechanisms in heart failure显示文摘 | Ashrafian H Frenneaux MP Opie LH | | 0，，04： | 1 |
| 11 | A mutation in the mitoehondrial fission gene Dnmll leads to cardiomyopathy 显示文摘 | Ashrafian H Docherty L Leo V | 2010 | PLoSGenet2010，6，10： | 1 |
| 12 | Body mass index category as a risk factor for colorectal adenomas: A systematic review and meta-a- nalysis显示文摘 | OKABAYASHI K ASHRAFIAN H HASEGAWA H | 2012 | Am J Gastroenterol2012，107，： | 1 |
| 13 | Metabolic mechanisms in heart Failure显示文摘 | Ashrafian H Frenneaux MP Dpie LH | 2007 | Circulation2007，116，4： | 1 |
| 14 | Inherited cardiomyopathies显示文摘 | Watkins H Ashrafian H Redwood C | 2011 | N Engl J Med2011，364，17： | 1 |
| 15 | Metabolic mechanisms in heart failure显示文摘 | Ashrafian H Frenneaux MP Opie LH | 2007 | Circulation2007，116，4： | 1 |
| 16 | Metabolic mechanisms in heart failure显示文摘 | Ashrafian H Frenneaux MP Opie LH | | 0，，： | 1 |
| 17 | Body mass index category as a risk factor for eolorectal adeno- mas: a systematic review and meta-analysis 显示文摘 | Okabayashi K Ashrafian H Hasegawa H | 2012 | Am J Gastroenterol2012，107，8： | 1 |
| 18 | Adhesions after abdominal surgery: A systematic review of the incidence, distribution and severity显示文摘 | OKABAYASHI K ASHRAFIAN H ZACHARAKIS E | 2014 | Surg Today2014，44，3： | 1 |
| 19 | Body mass index category as a risk factor for colorectal adenomas:a systematic review and meta-analysis显示文摘 | Okabayashi K Ashrafian H Hasegawa H | 2012 | Am J Gastroenterol2012，107，8： | 1 |
| 20 | Metabolic mecha- nisms in heart failure显示文摘 | Ashrafian H Frenneaux MP Opie LH | 2007 | Circulation2007，116，4： | 1 |
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