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| 1 | Liver transplantation in alcoholic liver disease current status and controversies显示文摘Alcoholic cirrhosis remains the second most common indication for liver transplantation.A comprehensive medical and psychosocial evaluation is needed when making a decision to place such patients on the transplant list.Most transplant centers worldwide need a minimum of 6 mo of alcohol abstinence for listing these patients.Patients with alcohol dependence are at high risk for relapse to alcohol use after transplantation(recidivism).These patients need to be identified and require alcohol rehabilitation treatment before transplantation.Recidivism to the level of harmful drinking is reported in about 15%-20%cases.Although,recurrent cirrhosis and graft loss from recidivism is rare,occurring in less than 5%of all alcoholic cirrhosis-related transplants,harmful drinking in the post-transplant pe-riod does impact the long-term outcome.The development of metabolic syndrome with cardiovascular events and de novo malignancy are important contributors to non liver-related mortality amongst transplants for alcoholic liver disease.Surveillance protocols for earlier detection of de novo malignancy are needed to improve the long-term outcome.The need for a minimum of 6 mo of abstinence before listing makes transplant a nonviable option for patients with severe alcoholic hepatitis who do not respond to corticosteroids.Emerging data from retrospective and prospective studies has challenged the 6 mo rule,and beneficial effects of liver transplantation have been reported in select patients with a first episode of severe alcoholic hepatitis who are unresponsive to steroids. | Ashwani K Singal Khushdeep S Chaha Khalid Rasheed Bhupinderjit S Anand | 2013 | World Journal of Gastroenterology2013，19，36： | 12 |
| 2 | Management of hepatitis C virus infection in HIV/HCV co-infected patients: Clinical review显示文摘Nearly one fourth of individuals with human immunodeficiency virus (HIV) infection have hepatitis C virus (HCV) infection in the US and Western Europe. With the availability of highly active antiretroviral therapy and the consequent reduction in opportunistic infections, resulting in the prolongation of the life span of HIV-infected patients, HCV co-infection has emerged as a signif icant factor influencing the survival of HIV patients. Patients with HIV/HCV co-infection have a faster rate of fibrosis progression resulting in more frequent occurrences of cirrhosis, end-stage liver disease, and hepatocellular carcinoma. However, the mechanism of interaction between the two viruses is not completely understood. The treatment for HCV in co-infected patients is similar to that of HCV monoinfection; i.e., a combination of pegylated interferon and ribavirin. The presence of any barriers to antiHCV therapy should be identified and eliminated in order to recruit all eligible patients. The response to treatment in co-infected patients is inferior compared to the response in patients with HCV mono-infection. The sustained virologic response rate is only 38% for genotype-1 and 75% for genotype-2 and -3 infections. Liver transplantation is no longer considered a contraindication for end-stage liver disease in coinfected patients. However, the 5 year survival rate is lower in co-infected patients compared to patients with HCV mono-infection (33% vs 72%, P = 0.07). A better understanding of liver disease in co-infected patients is needed to derive new strategies for improving outcome and survival. | Ashwani K Singal Bhupinderjit S Anand | 2009 | World Journal of Gastroenterology2009，15，30： | 12 |
| 3 | Molecular mechanisms of salinity tolerance in rice显示文摘Salinity is one of the major abiotic stresses which impose constraints to plant growth and production.Rice(Oryza sativa L.)is one of the most important staple food crops and a model monocot plant.Its production is expanding into regions that are affected by soil salinity,requiring cultivars more tolerant to saline conditions.Understanding the molecular mechanisms of such tolerance could lay a foundation for varietal improvement of salt tolerance in rice.In spite of extensive studies exploring the mechanism of salt tolerance,there has been limited progress in breeding for increased salinity tolerance.In this review,we summarize the information about the major molecular mechanisms underlying salinity tolerance in rice and further discuss the limitations in breeding for salinity tolerance.We show that numerous gene families and interaction networks are involved in the regulation of rice responses to salinity,prompting a need for a comprehensive functional analysis.We also show that most studies are based on whole-plant level analyses with only a few reports focused on tissue-and/or cell-specific gene expression.More details of salt-responsive channel and transporter activities at tissue-and cell-specific level still need to be documented before these traits can be incorporated into elite rice germplasm.Thus,future studies should focus on diversity of available genetic resources and,particular,wild rice relatives,to reincorporate salinity tolerance traits lost during domestication. | Tianxiao Chen Sergey Shabala Yanan Niu Zhong-Hua Chen Lana Shabala Holger Meinke Gayatri Venkataraman Ashwani Pareek Jianlong Xu Meixue Zhou | 2021 | The Crop Journal2021，9，3： | 11 |
| 4 | Buttress plating for a rare case of comminuted medial condylar Hoffa fracture associated with patellar fracture显示文摘Hoffa 骨折是不平常的 injury.In 文学,侧面的 condylar Hoffa 骨折比中间的 condylar Hoffa 骨折作为一个更普通的损害模式被提及。损害的机制和处理的方法很好没在文学被描述。我们与 ipsilateral 正在介绍弄碎的中间的 condylar Hoffa 骨折的一个稀罕盒子膝盖骨的骨折。损害的机制没在文学被描述。落后螺丝钉固定,是处理的最可接受的方法,不由于粉碎是可能的。我们解释损害的可能的机制并且与 L-but-tress 板修理破裂。 | Ashwani Soni Ramesh K Sen Uttam Chand Saini Dajjit Singh Sushil Chaudhary | 2012 | Chinese Journal of Traumatology2012，15，4： | 9 |
| 5 | Corticosteroids and pentoxifylline for the treatment of alcoholic hepatitis:Current status显示文摘The treatment of choice for patients with severe alcoholic hepatitis (AH) is use of corticosteroids.Many randomized well designed studies have been reported from all over the world on the use of corticosteroids in the treatment of AH.However,the data on the efficacy of corticosteroids in these patients have been conflicting.Initial meta-analyses also failed to show beneficial effects of corticosteroids.Based on individual data meta-analysis showing clear benefit of corticosteroids amongst patients with severe AH (modified discriminant function of 32 or more),led American College of Gastroenterology to recommend use of corticosteroids as the first line treatment option amongst patients with severe AH.However,corticosteroids are relatively contraindicated amongst patients with severe AH and coexistent sepsis,gastrointestinal bleeding,and acute pancreatitis.These patients may be candidates for second line treatment with pentoxifylline.Further,specific treatment of AH with corticosteroids far from satisfactory with as many as 40%-50% of patients failing to respond to steroids,thus classified as nonresponsive to steroids.The management of these patients is a continuing challenge for physicians.Better treatment modalities need to be developed for this group of patients in order to improve the outcome of patients with severe AH.This article describes at length the available trials on use of corticosteroids and pentoxifylline with their current status.Route of administration,dosage,adverse effects,and mechanisms of action of these two drugs are also discussed.Finally,an algorithm with clinical approach to management of patients who present with clinical syndrome of AH is described. | Ashwani K Singal Ishmeet Walia Anjna Singal Roger D Soloway | 2011 | World Journal of Hepatology2011，3，8： | 7 |
| 6 | Dynamic contribution of variable-speed wind energy conversion system in system frequency regulation显示文摘在让大风驱动穿入的产生混合的频率规定是一个关键问题,作为单位从在有先进力量电子学控制器和还原剂等价物系统惯性的骚乱期间的格子孤立的风。因此,风汽轮机也贡献系统频率控制,是重要的。这份报纸检验基于的二倍地喂的正式就职生成器(DFIG ) 的动态贡献在系统频率规定的风汽轮机。修改惯性的支持计划被建议它帮助 DFIG 提供短术语短暂活跃力量支持到格子在 transients 和拘捕期间在频率的秋天。频率偏差被控制器考虑提供惯性的控制。另外的参考书力量产量被使用它帮助 DFIG 释放在汽轮机的旋转群众中存储的动能。最佳的速度控制参数被用于 DFIG 到增加它在频率控制的参予。在一个二区域的互连的力量系统执行的模拟在负担频率控制表明 DFIG 的贡献。 | Yajvender Pal VERMA Ashwani KUMAR | 2012 | Frontiers in Energy2012，6，2： | 4 |
| 7 | Use of gentamicin-loaded collagen sponge in internal fixation of open fractures显示文摘ObjectiveTo 经由逐渐地在介绍给我们的开的破裂的外科的治疗局部地释放抗菌素的使妊娠的骨胶原敲诈的抗菌素(gentamicin骨胶原和抗菌素海绵)的申请估计立即的板 osteosynthesis 的结果在 injury.MethodsAll 盒子以后的 6 个小时包括 35 个病人在我们的第三级的水平损伤中心和教学医院被对待与开的破裂被立即的开的减小和板固定从2008年1月对待到 Augu 在他们之中, 31 个病人为足够的后续和评价是可得到的。所有破裂被灌溉对待,与释放抗菌素的骨胶原的放置一起的清创术,立即的开的减小和板固定就在创伤的闭合前在板附近敲诈。病人们被估计决定手术后的感染,推迟的联合或不属于工会并且另外的手术后的复杂并发症的开发。在彻底的清创术和本地抗菌素以后的立即的板 osteosynthesis 将在开的 fractures.ResultsThe 的治疗给安全、可接受的临床的结果,这被假设有足够的最后的后续的 31 个病人在 40 个星期(15-160 星期) 的一吝啬的时间被估计。大多数破裂根据参与的区域首先在一个可接受的时间时期联合起来。本地创伤复杂并发症(表面的感染和皮损失) 在 3 个病人(9.67%) 被发现。深感染在 2 个病人(6.45%) 被注意。任何一个都需要不这些病人植入在到期的时间统一的移动和两个破裂。推迟的联合在 5 个病人(16.13%) 被注意。没有病人进行了到不属于工会或在长期的后续植入失败。过多的结疤在 2 被开发在骨胶原电影 elut-ing 抗菌素的足够的清创术和放置以后的病人(6.45%).ConclusionsImmediate 板 osteosynthesis 局部地关于骨头联合和深感染的缺席生产优秀结果并且是在开的骨头损害的管理的一种安全技术。这些海绵能与内部固定的任何形式容易被使用,自从他们是 bioabsorbable,没有为这些抗菌素搬运人的移动的第二个手术的需要。与为 3 ~ 5 天的全身的抗菌素一起的本地使抗菌素妊娠的骨胶原海绵在开的破裂管理提供有希望的结果。 | Chaudhary Susheel Sen Ramesh Saini Uttam Chand Soni Ashwani Gahlot Nitesh Singh Daljit | 2011 | Chinese Journal of Traumatology2011，14，4： | 4 |
| 8 | Internal fixation and bone grafting for intraarticular nonunion of tibial plateau: a report of four cases显示文摘胫骨的高原不属于工会的 Intraarticular 是稀罕的。在文学,仅仅 9 个病人被发现为不属于工会的胫骨的高原和他们得到了改变结果的 intraarticular 被对待。与骨头 grafting 一起的内部固定在所有情况中作为标准治疗被做。我们对待 intraarticular 的 4 个不同侧面案例在我们由 4 个不同方法的机构不属于工会的胫骨的高原。我们与骨头接枝,有 K 钉子的 arthrodesis 和全部的膝代替一起与巴黎扔的、内部固定的灰浆对待这些案例。大小写 1 与当病人拒绝了外科,扔的巴黎(流行音乐) 的灰浆被对待。破裂被统一,尽管有外翻足 malalignment,病人充分对运动的完整的范围满意。大小写 2 与开的减小被管理与骨头 grafting 一起的内部固定。病人有一个好工会并且在膝关节得到了运动的完整的范围。大小写 3 由于她的老年与全部的膝关节造形术被对待并且得到了令人满意的结果。大小写 4 是一感染不属于工会。Arthrodesis 被做,病人能与忍受 independently.We 的完整的重量走断定与骨头 grafting 一起的那内部固定不能在胫骨的高原不属于工会的 intraarticular 的所有情况中是合适的。不属于工会的、现在的状况的原因和膝关节的运动的范围都应该被考虑,治疗应该根据每种 patient’s 状况是 individualised。 | Ramesh K Sen Ashwani Soni Uttam Chand Saini Daljit Singh | 2011 | Chinese Journal of Traumatology2011，14，6： | 4 |
| 9 | Liver transplantation in acute alcoholic hepatitis:Current status and future development显示文摘Acute alcoholic hepatitis (AH) is a distinct clinical entity amongst patients with chronic alcohol abuse.Patients with severe AH are at risk of dying in about 20%-25% cases despite specific treatment with corticosteroids and/or pentoxifylline.Clearly,a need for an additional more effective treatment option is unmet currently.Liver transplantation (LT),a definitive treatment option for alcoholic cirrhosis requires 6 mo abstinence.However,this rule cannot be applied to patients with AH as these patients are actively drinking prior to their presentation.Shortage of donors,ethical issues,and fear of recidivism after transplantation with less than 6 mo pretransplant abstinence are some of the reasons behind this rule of 6 mo of abstinence and hesitancy of transplanting patients with AH.These issues are debated at length in this manuscript.Further,retrospective studies have shown that patients undergoing transplantation for alcoholic cirrhosis and having histological changes of AH have been shown to fare as well when compared to patients without these histological changes.Recently,French workers have reported a case matched prospective study showing encouraging data on the usefulness of LT for patients who are non-responders to cortico-steroid and/or pentoxifylline therapy.Future studies are needed to identify patients with severe AH who are going to benefit most with LT.In the light of emerging data on the efficacy of LT in improving survival of patients with severe acute AH who do not respond to corticosteroids,the time is ripe to re-evaluate our policy of LT in patients with AH. | Ashwani K Singal Andrea Duchini | 2011 | World Journal of Hepatology2011，3，8： | 4 |
| 10 | A review of ecological risk assessment and associated health risks with heavy metals in sediment from India显示文摘Heavy metal(HM)pollution in sediment is a serious concern particularly in developing nations,warranting an extensive survey to understand the current situation and propose possible remedial measures.This paper compiles the data of HMs cadmium(Cd),iron(Fe),cobalt(Co),manganese(Mn),arsenic(As),lead(Pb),chromium(Cr),copper(Cu),zinc(Zn)and nickel(Ni)in aquatic sediment from India from 1979 to 2017.It was found that mean values of Cu,Co,Zn,Pb,As,and Cr in Indian sediment were high in comparison to the Australian Interim Sediment Quality Guidelines,World Surface Rock Average,and the Threshold Effect Level for freshwater ecosystems.Anthropogenic activities,lithogenic factors,and sand intrusion are the main factors associated with HM pollution as observed using cluster analysis and principal component analysis.The results of contamination indices indicate that HM contamination ranged from average to high,in the sediment.The ecological risk assessment results showed that 11%HMs present very high risk.The cancer risk,due to the high contents of Cd,As,and Cr the ingestion pathway,showed high risk of cancer through food/water contaminated with sediment.At source reduction of HMs in industrial effluents by effluent treatment plants,and plantation of phytoremediating rooted macrophytes in sediment may help in HM mitigation of the sediment. | Vinod Kumar Anket Sharma Shevita Pandita Renu Bhardwaj Ashwani Kumar Thukral Artemi Cerda | 2020 | International Journal of Sediment Research2020，35，5： | 4 |
| 11 | Alcoholic Hepatitis: Current challenges and future directions显示文摘 | Ashwani K. Singal Patrick S. Kamath Gregory J. Gores Vijay H. Shah | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 3 |
| 12 | Mesenteric Venous Thrombosis显示文摘 | Ashwani K. Singal Patrick S. Kamath Ayalew Tefferi | 2013 | Mayo Clinic Proceedings2013，，3： | 3 |
| 13 | Reactive power compensation of an isolated hybrid power system with load interaction using ANFIS tuned STATCOM显示文摘 | Nitin SAXENA Ashwani KUMAR | 2014 | Frontiers in Energy2014，8，2： | 3 |
| 14 | Multi-objective energy management in microgrids with hybrid energy sources and battery energy storage systems显示文摘Microgrid with hybrid renewable energy sources is a promising solution where the distribution network expansion is unfeasible or not economical.Integration of renewable energy sources provides energy security,substantial cost savings and reduction in greenhouse gas emissions,enabling nation to meet emission targets.Microgrid energy management is a challenging task for microgrid operator(MGO)for optimal energy utilization in microgrid with penetration of renewable energy sources,energy storage devices and demand response.In this paper,optimal energy dispatch strategy is established for grid connected and standalone microgrids integrated with photovoltaic(PV),wind turbine(WT),fuel cell(FC),micro turbine(MT),diesel generator(DG)and battery energy storage system(ESS).Techno-economic benefits are demonstrated for the hybrid power system.So far,microgrid energy management problem has been addressed with the aim of minimizing operating cost only.However,the issues of power losses and environment i.e.,emission-related objectives need to be addressed for effective energy management of microgrid system.In this paper,microgrid energy management(MGEM)is formulated as mixedinteger linear programming and a new multi-objective solution is proposed for MGEM along with demand response program.Demand response is included in the optimization problem to demonstrate it’s impact on optimal energy dispatch and techno-commercial benefits.Fuzzy interface has been developed for optimal scheduling of ESS.Simulation results are obtained for the optimal capacity of PV,WT,DG,MT,FC,converter,BES,charging/discharging scheduling,state of charge of battery,power exchange with grid,annual net present cost,cost of energy,initial cost,operational cost,fuel cost and penalty of greenhouse gases emissions.The results show that CO_(2) emissions in standalone hybrid microgrid system is reduced by 51.60%compared to traditional system with grid only.Simulation results obtained with the proposed method is compared with various evolutionary algorithms to verify it’s effectiveness. | V.V.S.N.Murty Ashwani Kumar | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 3 |
| 15 | Alcoholic hepatitis and concomitant hepatitis C virus infection显示文摘Hepatitis C virus(HCV)infection and alcohol abuse are two most important causes of chronic liver disease in the United States.Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality.About 20%of patients presenting with alcoholic hepatitis have concomitant HCV infection.Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage.Large prospective randomized studies are needed to develop guidelines on the use of corticosteroids among patients with alcoholic hepatitis and concomitant HCV infection.The impact of antiviral therapy on mortality and outcome in the setting of alcoholic hepatitis remains a novel area for future research. | Mohamed Shoreibah Bhupinderjit S Anand Ashwani K Singal | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 16 | Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma显示文摘AIM To investigate the effect of lycopene extracted from tomatoes(LycT) on ultrastructure, glycolytic enzymes, cell proliferation markers and hypoxia during N-Nitrosodiethylamine(NDEA)-induced hepatocarcinogenesis. METHODS Female BALB/c mice were randomly divided into four groups: The Control, NDEA(200 mg NDEA/kg b.w. given i.p.), LycT(5 mg/kg b.w. given orally on alternate days) and Lyc T + NDEA group. The m RNA and protein expression of various cell proliferation markers(PCNA, Cyclin D1, and p21) were assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay, respectively. The ultrastructure of hepatic tissue was analyzed using scanning and transmission electron microscopy. The enzymatic activity of glycolytic enzymes was estimated using standardized protocols, while glucose-6-phosphate dehydrogenase activity level was estimated using a kit obtained from Reckon Diagnostic P. Ltd.(India). RESULTS Uncontrolled proliferation in the liver of NDEA(P ≤ 0.001) mice was evident from the high expression of cell-proliferation associated genes(PCNA, Cyclin D1, and p21) when compared to control and Lyc T mice. In addition, enhanced activities of hexokinase, phosphoglucoisomerase, aldolase, glucose-6-phosphatedehydrogenase and hypoxia-inducible factor-1α were observed in NDEA mice as compared to control(P ≤ 0.001) and Lyc T(P ≤ 0.001) mice. The alterations in hepatic ultrastructure observed in the NDEA group correlated with the changes in the above parameters. Lyc T pre-treatment in NDEA-challenged mice ameliorated the investigated pathways disrupted by NDEA treatment. Moreover, hepatic electron micrographs from the Lyc T + NDEA group showed increased macrophages, apoptotic bodies and well-differentiated hepatocellular carcinoma(HCC) in comparison to undifferentiated HCC as observed in the NDEA treated group. CONCLUSION This study demonstrates that dietary supplementation with Lyc T has a multidimensional role in preventing HCC development. | Prachi Gupta Nisha Bhatia Mohinder Pal Bansal Ashwani Koul | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 17 | Femoral head fracture without hip dislocation显示文摘没有脱臼或 subluxation 的大腿骨的头破裂是极其稀罕的损害。没有一年持续时间的新潮的脱臼或 subluxation,我们在由于道路交通事故支撑了一处高精力损伤的一个 36 岁的病人报导大腿骨的头的孤立的弄碎的骨折的一个忽视的案例。他与痛苦的右臀部和无能介绍了与 39 中的哈里斯臀部 20 个在恰好更低的手足上忍受完整的重量。他收到了无水泥的全部的新潮的代替。在 2.3 年的最近的后续,功能的结果与 95 中的哈里斯臀部 20 个是优秀的。如此的孤立的损害在文学被描述了仅仅一次并且没被分类到现在为止。这份报告的目的是加亮极端稀有,包含的可能的机制和分类如此的损害的一个新奇分类系统。 | Aditya K Aggarwal Ashwani Soni Daljeet Singh | 2013 | Chinese Journal of Traumatology2013，16，5： | 2 |
| 18 | Management practices of hepatitis C virus infected alcoholic hepatitis patients:A survey of physicians显示文摘AIM:To survey gastroenterologists and hepatologists regarding their current views on treating hepatitis C virus(HCV) infected alcoholic hepatitis(AH) patients.METHODS:A sixteen item questionnaire was electronically mailed to gastroenterologists and hepatologists.A reminder was sent after 2 mo to increase the response rate.Participation of respondents was confidential.Accessing secured web site to respond to the questionnaire was considered as informed consent.Responses received on the secured website were downloaded in an excel sheet for data analysis.RESULTS:Analyzing 416 responses to 1556(27% response rate) emails,57% respondents(56% gastroenterologists) reported HCV prevalence > 20% amongst AH patients.Sixty nine percent often treated AH and 46% preferred corticosteroids(CS).Proportion of respondents with consensus(75% or more respondents agreeing on question) on specific management of HCV infected AH were:routine HCV testing(94%),HCV not changing response to CS(80%) or pentoxifylline(91%),no change in approach to treating HCV infected AH(75%).None of respondent variables:age,specialty,annual number of patients seen,and HCV prevalence could predict respondent to be in consensus on any of or all 4 questions.Further,only 4% would choose CS for treating HCV infected AH as opposed to 47% while treating HCV negative AH.CONCLUSION:Gastroenterologists and hepatologists believe that AH patients be routinely checked for HCV.However,there is lack of consensus on choice of drug for treatment and outcome of HCV positive AH patients.Studies are needed to develop guidelines for management of HCV infected AH patients. | Ashwani K Singal Habeeb Salameh Anjna Singal Sarat C Jampana Daniel H Freeman Karl E Anderson Don Brunder | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 2 |
| 19 | Mesenteric Venous Thrombosis显示文摘 | Bashar Hmoud Ashwani K. Singal Patrick S. Kamath | 2014 | Journal of Clinical and Experimental Hepatology2014，，： | 2 |
| 20 | In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts显示文摘OBJECTIVE: Different parts of Murraya paniculata have been used traditionally for treating several ailments including mental disorders. The present study was designed to evaluate the antianxiety and antidepressant potential of M. paniculata leaves using elevated plus maze model and forced swim test, respectively.METHODS: Extracts of M. paniculata made with petroleum ether(60–80 °C), chloroform, ethanol and water were evaluated for antianxiety and antidepressant activity. The anxiolytic chloroform extract was subjected to column chromatography, yielding five fractions(F_1–F_5). Fraction F_5(100 mg/kg), which showed notable anxiolytic activity, was further chromatographed to get four subfractions(F_(5.1)–F_(5.4)). Simultaneously, the ethanol extract was partitioned with ethyl acetate to obtain ethyl acetate soluble fraction(EASF) and ethyl acetate insoluble fraction. Phytochemical screening of bioactive extracts/fractions and detection of mahanimbine in M. paniculata leaf extract by thin-layer chromatography was also carried out.RESULTS: Fraction F_(5.3)(25 mg/kg) and EASF(20 mg/kg) showed significant anxiolytic and antidepressant activity, respectively. Thin-layer chromatography and phytochemical screening demonstrated the absence of mahanimbine in M. paniculata leaves. Coumarins were observed to be responsible for the anxiolytic activity.CONCLUSION: The results validate the traditional use of M. paniculata leaves in the treatment of mental disorders. | Pragya Sharma Sonali Batra Ashwani Kumar Anupam Sharma | 2017 | Journal of Integrative Medicine2017，15，4： | 2 |
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