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| 1 | Methods for improving thermal tolerance in military personnel prior to deployment显示文摘Acute exposure to heat, such as that experienced by people arriving into a hotter or more humid environment, can compromise physical and cognitive performance as well as health. In military contexts heat stress is exacerbated by the combination of protective clothing, carried loads, and unique activity profiles, making them susceptible to heat illnesses. As the operational environment is dynamic and unpredictable, strategies to minimize the effects of heat should be planned and conducted prior to deployment. This review explores how heat acclimation(HA) prior to deployment may attenuate the effects of heat by initiating physiological and behavioural adaptations to more efficiently and effectively protect thermal homeostasis, thereby improving performance and reducing heat illness risk. HA usually requires access to heat chamber facilities and takes weeks to conduct, which can often make it impractical and infeasible, especially if there are other training requirements and expectations. Recent research in athletic populations has produced protocols that are more feasible and accessible by reducing the time taken to induce adaptations, as well as exploring new methods such as passive HA. These protocols use shorter HA periods or minimise additional training requirements respectively, while still invoking key physiological adaptations, such as lowered core temperature, reduced heart rate and increased sweat rate at a given intensity. For deployments of special units at short notice(< 1 day) it might be optimal to use heat re-acclimation to maintain an elevated baseline of heat tolerance for long periods in anticipation of such an event. Methods practical for military groups are yet to be fully understood, therefore further investigation into the effectiveness of HA methods is required to establish the most effective and feasible approach to implement them within military groups. | Edward Tom Ashworth James David Cotter Andrew Edward Kilding | 2021 | Military Medical Research2021，8，3： | 3 |
| 2 | The Bioconversion of (3RS,E)-and (3RS, Z)-nerolidol into oxygenated products by streptomyces cinnamonensis 显示文摘 | Holmes D S Ashworth D M | 1990 | Helv Chim Acta1990，73，2： | 2 |
| 3 | WJH 6^(th) Anniversary Special Issues(2): Hepatocellular carcinoma Mammalian target of rapamycin inhibition in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the leading causes of cancer-related death worldwide. It is associated with a poor prognosis and has limited treatment options. Sorafenib, a multi-targeted kinase inhibitor, is the only available systemic agent for treatment of HCC that improves overall survival for patients with advanced stage disease; unfortunately, an effective second-line agent for the treatment of progressive or sorafenib-resistant HCC has yet to be identified. This review focuses on components of the mammalian target of rapamycin(mTOR) pathway, its role in HCC pathogenesis, and dual mTOR inhibition as a therapeutic option with potential efficacy in advanced HCC. There are several important upstream and downstream signals in the mTOR pathway, and alternative tumor-promoting pathways are known to exist beyond mTORC1 inhibition in HCC. This review analyzes the relationships of the upstream and downstream regulators of mTORC1 and mTORC2 signaling; it also provides a comprehensive global picture of the interaction between mTORC1 and mTORC2 which demonstrates the pre-clinical relevance of the mTOR pathway in HCC pathogenesis and progression. Finally, it provides scientific rationale for dual mTORC1 and mTORC2 inhibition in the treatment of HCC. Clinical trials utilizing mTORC1 inhibitors and dual mTOR inhibitors in HCC are discussed as well. The mTOR pathway is comprised of two main components, mTORC1 and mTORC2; each has a unique role in the pathogenesis and progression of HCC. In phase Ⅲ studies, mTORC1 inhibitors demonstrate anti-tumor ac-tivity in advanced HCC, but dual mTOR(mTORC1 and mTORC2) inhibition has greater therapeutic potential in HCC treatment which warrants further clinical investigation. | René E Ashworth Jennifer Wu | 2014 | World Journal of Hepatology2014，6，11： | 2 |
| 4 | Adopting STEP for in Service C onfiguration Control显示文摘 | | 1996 | Computers in Indusrty1996，31，： | 1 |
| 5 | Determination of protein in dairy products by dye-binding显示文摘 | | 1966 | J Dairy Sci1966，49，： | 1 |
| 6 | Prevention of calcification of bioprosthetic heart valve cusp and aortic wall with ethanol and aluminum chloride显示文摘 | Clark JN Ogle MF Ashworth P | 2005 | The Annals of Thoracic Surgery2005，79，3： | 1 |
| 7 | Effect of pH,Aalcium,and Heat Treatment on Curd Tension of Casein Fraction Fortifoed Skim Milk显示文摘 | SCHULTZ D L ASHWORTH U S | 1974 | Journal of Dairy Science1974，57，3： | 1 |
| 8 | Creating What Sort of Professional? Master's Level Nurse Education As a Professionalising Strategy 显示文摘 | Gerrish K McManus M Ashworth P | 2003 | Nurs Inq2003，10，2： | 1 |
| 9 | The DNA damage response and cancer therapy显示文摘 | Lord C J Ashworth A | | 0，，： | 1 |
| 10 | A-67A Pilot Study of Age and Education Norms for the Montreal Cognitive Assessment 显示文摘 | Ashworth B Dilks L Hutchinson K | 2014 | Arch Clin Neuropsycho12014，29，6： | 1 |
| 11 | Hallmarks of 'BRCAness' in sporadic cancers 显示文摘 | Turner N Tutt A Ashworth A | 2004 | Nature Reviews Cancer2004，4，10： | 1 |
| 12 | Prevention of calcification of bioprosthetic heart valve cusp and aortic wall with ethanol and aluminum chloride显示文摘 | Clark JN Ogle MF Ashworth P | 2005 | Ann Thorac Surg2005，79，3： | 1 |
| 13 | Evidence of an association between the survival of embryos and the preiovulatory plasma progesterone concentration in the ewe显示文摘 | Ashworth C J Sakes D I Wilmut I | 1989 | J Reprod Fertil1989，87，： | 1 |
| 14 | Cardiovascular responses following laryngoscope assisted, fibreoptic orotracheal intubation 显示文摘 | Tong JL Ashworth DR Smith JE | 2005 | Anaesthesia2005，60，8： | 1 |
| 15 | Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans显示文摘 | FLETT AS HAYWARD MP ASHWORTH MT | 2010 | Circulation2010，122，2： | 1 |
| 16 | NLK is a novel therapeutic target for PTEN deficient tumour cells显示文摘 | Mendes-Pereira A M Lord C J Ashworth A | 2012 | PLoS One2012，7，47： | 1 |
| 17 | Identification of miRNA modulators to PARP inhibitor response显示文摘 | Sari Neijenhuis Ilirjana Bajrami Rowan Miller Christopher J. Lord Alan Ashworth | 2013 | DNA Repair2013，，6： | 1 |
| 18 | Waste incineration and adverse birth and neonatal outcomes: a systematic review 显示文摘 | Ashworth DC Elliott P Toledano MB | 2014 | Environ Int2014，69，： | 1 |
| 19 | Vitamin A deficiency during rat pregnancy alters placental TNF alpha signalling andapoptosis显示文摘 | ANTIPATIS C ASHWORTH CJ RILEY SC | 2002 | Am J Reprod Immunol2002，47，： | 1 |
| 20 | Laboratory Assessment of Emission Reduction Strategies for the Agricultural Fumigants 1,3-Dichloropropene and Chl0ropicrin显示文摘 | ASHWORTH D J ERNST F F XUAN Ri-cheng | 2009 | Environ Sci Technol2009，43，13： | 1 |
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