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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review显示文摘BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally.Though they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a challenge.This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification.Therefore,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers.Though,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been reported.There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions.AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and metastases.METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE scholar.The following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors]were used.Eligibility criteria were defined and all potential relevant items,including full articles and/or abstracts were independently reviewed,assessed and agreed upon items were selected for in-depth analysis.RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review.This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives,nomenclature,clinicoradiological features,pathology,treatment,prognosis and the current status of the management of both the primary lesions,their recurrences and metastases.Gaps in knowledge have also been identified and discussed.An important outcome of this manuscript is the justified proposal for a new,simple,clinically relevant,non-ambiguous terminology for these lesions to be referred to as mixed epithelial endocrine neoplasms(MEENs).CONCLUSION MEEN of the colon and rectum are poorly understood rare entities that encompass an extensive range of heterogeneous tumors with a wide variety of combinations leading to tumors of high,intermediate or low grade malignant potential.This proposed new revised terminology of MEEN will solve the biggest hurdle of confusion and misclassification that plagues these rare unique colorectal neoplasms thus facilitating the future design of multi institutional prospective randomized controlled clinical trials to develop and evaluate newer therapeutic strategies that are recommended for continued improved understanding and personal optimization of clinical management of these unique colorectal neoplasms. | Rani Kanthan Suresh Tharmaradinam Tehmina Asif Shahid Ahmed Selliah C Kanthan | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones显示文摘 | Asif C Koji M Ryuji M | 1996 | Gastroenterology1996，111，： | 1 |
| 4 | Siderophile and chalcophile metals as tracers of the evolution of the Siberian trap in the Noril' sk region,Russia显示文摘 | Brügmann G E Naldrett A J Asif M Lightfoot P C Gorbachev N S Fedorenko V A | | 0，，09： | 1 |
| 5 | Platinum-group elements in the Sudbury ores: Significance with respect to the origin of different ore zones and to the exploration for footwall orebodies 显示文摘 | Naldrett A J Asif M Scandl E Searcy T Morrison G G Binney W P Moore C | 1999 | Economic Geology1999，94，2： | 1 |
| 6 | Photopolymerization of waterborne polyurethane acrylate dispersions based on hyperbranched aliphatic polyester and properties of the cured films显示文摘 | Asif Anila Huang C Y Shi W F | 2004 | Colloid Polym Sci2004，283，： | 1 |
| 7 | UV curing behaviors and hydrophilic characteristics of UV curable waterborne hyperbranched aliphatic polyesters 显示文摘 | ASIF A HUANG C SHI W | 2003 | Polymers for Advanced Technologies2003，14，9： | 1 |
| 8 | The composition of ore at the Voisey's Bay Ni-Cu sulfide deposit with special reference to platinum-group elements显示文摘 | Naldrett A J Asif M Krstic S Li C | | 0，，： | 1 |
| 9 | Prebreakdown and breakdown effects in AIGaN/GaN het- rostructure field effect transistors 显示文摘 | Gradinaru G Asif Khan M Kao N C | 1998 | Appl Phys Lett1998，72，12： | 1 |
| 10 | DNA Extraction From Processed Wood: A Case Study for the Identification of an Endangered Timber Species (Gonystylus baneanus)显示文摘 | Asif M J Cannon C H | 2005 | Plant Molecular Biology Reporter2005，23，2： | 1 |
| 11 | Arterial steal syndrome:a modest proposal for an old paradigm显示文摘 | Asif A Leon C Merrill D | | 0，，： | 1 |
| 12 | Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity显示文摘 | Samanta K C Asif M Garg V | 2011 | E-J Chem2011，8，1： | 1 |
| 13 | Logarithmic versus modified digital backward propagation algorithm in 224 Gbit/s DP-16QAM transmission over dispersion uncompensated fiber links显示文摘 | R Asif C Y Lin B Schmauss | 2012 | Opt Eng2012，51，04： | 1 |
| 14 | New insights into the origin of perylene in geological samples 显示文摘 | Grice K Lu H Atahan P Asif M Hallmann C Greenwood P Maslen E Tulipani S Williford K Dodson J | 2009 | Geochim Cosmochim Acta2009，73，21： | 1 |
| 15 | Arteriovenous access and hand pain: the distal hypoperfusion ischemic syndrome显示文摘 | Leon C Asif A | 2007 | Clin J Am Soc Nephrol2007，2，1： | 1 |
| 16 | Structure-property study of waterborne, polyurethane acrylate dispersions based on hyperbranched aliphatic polyester for UV-curable coatings显示文摘 | ASIF A HUANG C Y SHI W F | 2004 | Colloid & Polymer Science2004，283，2： | 1 |
| 17 | UV curing behaviors and hydrophilic characteristics of UV curable waterborne hyperbranched aliphatic polyesters显示文摘 | Asif A Huang C Y Shi W F | 2003 | Polymers for advanced technologies2003，14，9： | 1 |
| 18 | Structure-property study of waterborne,polyurethane acrylate dispersions based on hyperbranched aliphatic polyester for UV-curable coatings显示文摘 | Asif A Huang C Y Shi W F | 2004 | Colloid and Polymer Science2004，283，2： | 1 |
| 19 | DNA extraction from processed wood: a case study for the identification of an endangered timber species (Gonystylus bancanus)显示文摘 | Asif M J Cannon C H | 2005 | Plant Molecular Biology Reporterl2005，23，： | 1 |
| 20 | Photopolymerization of Waterborne Polyurethane Acrylate Dispersions Based on Hyperbranched Aliphatic Polyester and Properties of the Cured Films显示文摘 | ASIF A HUANG C Y SHI W F | 2005 | Colloid Polymer Science2005，283，7： | 1 |
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