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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | The omega-3 and retinopathy of prematurity relationship显示文摘The aim of this article is to examine the effect of omega-3(ω-3) long-chain polyunsaturated fatty acids(LCPUFAs) intake on retinopathy of prematurity(ROP) by reviewing the experimental and clinical trials conducted on animal models and infants.LCPUFAs demonstrate cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina.Their intake appears to have a beneficial effect on ischemia,oxidative stress,inflammation and cellular signaling mechanisms,influencing retinal cell gene expression and cellular differentiation.ω-3 LCPUFAs may modulate metabolic processes that activate molecules implicated in the pathogenesis of vasoproliferative and neurodegenerative retinal diseases such as ROP. | Angelakis Malamas Angeliki Chranioti Christos Tsakalidis Stavros A Dimitrakos Asimina Mataftsi | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 4 |
| 3 | New endoscopy devices to improve population adherence to colorectal cancer prevention programs显示文摘Despite recent advances in medicine,colorectal cancer (CRC)remains one of the greatest hazards for public health worldwide and especially the industrialized world.It has been well documented with concrete data that regular screening colonoscopy aimed at early detection of precancerous polyps can help decrease the incidence of CRC.However,the adherence of the general population to such screening programs has been shown to be lower than that expected,thus allowing CRC to remain a major threat for public health.Various reasons have been suggested to explain the disappointing compliance of the population to CRC screening programs,some of them associated with colonoscopy per se,which is viewed by many people as an unpleasant examination.Governments,medical societies,individual gastroenterologists,as well as the medical industry are working in order to improve endoscopic devices and/or to improve standard colo-noscopy.The aim is to improve the acceptance of the population for this method of CRC screening,by providing a painless and reliable examination of the colon.This review focuses on some of the latest improve-me-nts in this fie-ld. | Asimina Gaglia Ioannis S Papanikolaou Wilfried Veltzke-Schlieker | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，7： | 2 |
| 4 | Separation ofazeotropic mixtures using hyperbranched polymers or i-onic liquids显示文摘 | CARSTEN J ASIMINA K WOLFGANG A | 2004 | AIChE Journal2004，50，10： | 1 |
| 5 | Introduction of a digital near-vision reading test for normal and low vision adults:development and validation显示文摘Background:MNREAD is an advanced near-vision acuity chart that has already been translated and validated in Greek language.Considering that no validated Greek digital near-vision test exists,our primary objective was to develop and validate a digital near-vision reading test based on the fundamental properties of the Greek printed MNREAD(MNREAD-GR).Methods:This is a prospective,comparative study.A digital near-vision chart was developed(Democritus Digital Acuity Reading Test-DDART)with text size calibration,audio recording for automatic reading timing,as well as automatic calculation of reading acuity(RA),maximum reading speed(MRS),critical print size(CPS)and reading accessibility index(ACC).Normal and low vision subjects participated in the validation process,responding to MNREAD-GR and DDART at the same day,at a 40 cm viewing distance.Differences in all parameters between the charts were compared with t-test and intraclass correlation coefficients(ICCs).Within 15 days,all participants responded again to DDART in a different set of sentences to assess its test-retest reliability.Results:One hundred patients(normal vision group-NVG:70 patients;low vision group-LVG:30 patients)responded to both reading tests.Non-significant differences were detected for all parameters between DDART and MNREAD-GR except for MRS and ACC that were significantly higher in MNREAD-GR in NVG(p<0.01).NVG participants demonstrated sufficient ICCs that ranged from 0.854 to 0.963,while LVG demonstrated ICCs for RA,ACC,MRS and CPS equal to 0.986,0.894,0.794 and 0.723,respectively.All parameters calculated with DDART demonstrated excellent test-retest reliability(ICCs:0.903-0.956).Conclusions:The proposed reading test presented comparable validity and repeatability to MNREAD-GR suggesting that it can be used both in normal and low vision Greek patients. | Georgios Labiris Eirini-Kanella Panagiotopoulou Eleftherios Chatzimichael Maria Tzinava Asimina Mataftsi Konstantinos Delibasis | 2020 | Eye and Vision2020，7，1： | 1 |
| 6 | Long-term refractive stability following combined astigmatic keratotomy and phakoemulsification显示文摘 | Avinash Kulkarni Asimina Mataftsi Ash Sharma Ambreen Kalhoro Simon Horgan | 2009 | International Ophthalmology2009，，2： | 1 |
| 7 | Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea显示文摘 | Fotis Kapsimalis George Varouchakis Asimina Manousaki Spiros Daskas Dimitra Nikita Meir Kryger Konstantinos Gourgoulianis | 2008 | Lung2008，，4： | 1 |
| 8 | Effects of long-term culture on human embryonic stem cell aging显示文摘 | Xie X Y Asimina Hiona Andrew Lee | 2011 | Stem Cells2011，20，1： | 1 |
| 9 | Chiasmatic Infiltration Secondary to Late Malignant Transformation of Retinoma显示文摘 | Asimina Mataftsi Leonidas Zografos Aubin Balmer Sylvie Uffer Roger Stupp Robert C. Janzer Alessia Pica Daniel F. Schorderet Francis L. Munier | 2012 | Ophthalmic Genetics2012，，3： | 1 |
| 10 | FMRI as a molecular imaging pro- cedure for the functional reorganization of motor systems in chronic stroke 显示文摘 | Lazaridou Asimina Astrakas Loukas Mintzopoulos Dionyssios | 2013 | Molecular medicine reports2013，8，3： | 1 |
| 11 | Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity显示文摘 | Michael S Hannele YJ Asimina M | 2000 | Diabetes Care2000，23，： | 1 |
| 12 | Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity显示文摘 | Stumvoll M Hannele YJ Asimina M | 2000 | Diabetes Care2000，23，3： | 1 |
| 13 | Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea显示文摘 | Fotis Kapsimalis George Varouchakis Asimina Manousaki | 2008 | Lung2008，186，： | 1 |
| 14 | Multimode pushover analysis for asymmetric buildings under biaxial seismic excitation based on a new concept of the equivalent single degree of freedom system显示文摘 | Grigorios Manoukas Asimina Athanatopoulou Ioannis Avramidis | 2012 | Soil Dynamics and Earthquake Engineering2012，，： | 1 |
| 15 | Cultural differences, experi-ence with social networks and the nature of true commitment in Face-book 显示文摘 | ASIMINA V ADAM NJ DELPHINE C | 2010 | Int J Hum-comput Studies2010，68，10： | 1 |
| 16 | Effect of panel reactive antibodies on T cell immunity reinstatement following renal transplantation显示文摘BACKGROUND Chronic kidney disease is associated with immunological disorders,presented as phenotypic alterations of T lymphocytes.These changes are expected to be restored after a successful renal transplantation;however,additional parameters may contribute to this process.AIM To evaluate the impact of positive panel reactive antibodies(PRAs)on the restoration of T cell phenotype,after renal transplantation.METHODS CD4CD28null,CD8CD28null,natural killer cells(NKs),and regulatory T cells(Tregs)were estimated by flow cytometry at T0,T3,and T6 which were the time of transplantation,and 3-and 6-mo follow-up,respectively.Changes were estimated regarding the presence or absence of PRAs.RESULTS Patients were classified in two groups:PRA(-)(n=43)and PRA(+)(n=28)groups.Lymphocyte and their subtypes were similar between the two groups at T0,whereas their percentage was increased at T3 in PRA(-)compared to PRA(+)[23(10.9-47.9)vs 16.4(7.5-36.8)μ/L,respectively;P=0.03].Lymphocyte changes in PRA(-)patients included a significant increase in CD4 cells(P<0.0001),CD8 cells(P<0.0001),and Tregs(P<0.0001),and a reduction of NKs(P<0.0001).PRA(+)patients showed an increase in CD4(P=0.008)and CD8(P=0.0001),and a reduction in NKs(P=0.07).CD4CD28null and CD8CD28null cells,although initially reduced in both groups,were stabilized thereafter.CONCLUSION Our study described important differences in the immune response between PRA(+)and PRA(-)patients with changes in lymphocytes and lymphocyte subpopulations.PRA(+)patients seemed to have a worse immune profile after 6 mo follow-up,regardless of renal function. | Lampros Vagiotas Maria Stangou Efstratios Kasimatis Aliki Xochelli Grigorios Myserlis Georgios Lioulios Vasiliki Nikolaidou Manolis Panteli Konstantinos Ouranos Nikolaos Antoniadis Daoudaki Maria Aikaterini Papagianni Georgios Tsoulfas Asimina Fylaktou | 2022 | World Journal of Transplantation2022，12，10： | 0 |
| 17 | Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19显示文摘N-acetylcysteine(NAC)is an abundantly available antioxidant with a wide range of antidotal properties currently best studied for its use in treating acetaminophen overdose.It has a robustly established safety profile with easily tolerated side effects and presents the Food and Drug Administration's approval for use in treating acetaminophen overdose patients.It has been proven efficacious in offlabel uses,such as in respiratory diseases,heart disease,cancer,human immunodeficiency virus infection,and seasonal influenza.Clinical trials have recently shown that NAC's capacity to replenish glutathione stores may significantly improve coronavirus disease 2019(COVID-19)outcomes,especially in high risk individuals.Interestingly,individuals with glucose 6-phosphate dehydrogenase deficiency have been shown to experience even greater benefit.The same study has concluded that NAC's ability to mitigate the impact of the cytokine storm and prevent elevation of liver enzymes,C-reactive protein,and ferritin is associated with higher success rates weaning from the ventilator and return to normal function in COVID-19 patients.Considering the background knowledge of biochemistry,current uses of NAC in clinical practice,and newly acquired evidence on its potential efficacy against COVID-19,it is worthwhile to investigate further whether this agent can be used as a treatment or adjuvant for COVID-19. | Asimina Dominari Donald Hathaway III Abdulhusein Kapasi Trissa Paul Sarabjot Singh Makkar ValeriaCastaneda Sirisha Gara Bishnu Mohan Singh Kuchalambal Agadi Maliha Butt Varadha Retnakumar Spandana Chittajallu Rahima Taugir Muhammad Khawar Sana Manish KC Sarah Razzack Niala Moallem Alina Alvarez Michael Talalaev | 2021 | World Journal of Virology2021，10，2： | 0 |
| 18 | Gastroenterology and liver disease during COVID-19 and in anticipation of post-COVID-19 era: Current practice and future directions显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has emerged as a major threat to global public health.The virus causes the clinical syndrome known as coronavirus disease 2019(COVID-19),in which multiple organs can get affected.Apart from manifestations of the respiratory system,which predominate,its clinical presentation is frequently accompanied by symptoms of the gastrointestinal(GI)tract and liver abnormalities.The correlation of symptoms and abnormalities with disease severity is discussed,leading to ambiguous results from international literature.Moreover,the disease infects patients with coexisting liver and GI disorders affecting both their health status and the availability of healthcare services provided to them.The risk of transmission of the disease during aerosol-generating procedures has changed the diagnostic approach and follow-up algorithms for liver and GI diseases.For the safety of both doctors and patients,telemedicine and distant evaluation have become everyday practice,whereas several routines and emergency visits at outpatient and emergency departments have been postponed or delayed.Vaccination against SARS-CoV-2 is underway,providing hope to humanity and the expectation that the post-COVID-19 era is near.This review aims to update knowledge about the manifestations of COVID-19 related to liver and GI diseases and the effect of the pandemic on the diagnostic and therapeutic procedures for these diseases with a special focus on how current practices have changed and what changes will possibly remain in the future. | Katerina G Oikonomou Panagiotis Papamichalis Tilemachos Zafeiridis Maria Xanthoudaki Evangelia Papapostolou Asimina Valsamaki Konstantinos Bouliaris Michail Papamichalis Marios Karvouniaris Panagiotis J Vlachostergios Apostolia-Lemonia Skoura Apostolos Komnos | 2021 | World Journal of Clinical Cases2021，9，19： | 0 |
| 19 | Design of Monolithic Concrete Ground Floors显示文摘 | Alexandros D. Bantias Ioannis A. Tegos Theodoros A. Chrysanidis Asimina M. Athanatopoulou | 2014 | Journal of Civil Engineering and Architecture2014，8，7： | 0 |
| 20 | Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions显示文摘Clinically,it is highly challenging to promote recovery in patients with acute liver failure(ALF)and acute-on-chronic liver failure(ACLF).Despite recent advances in understanding the underlying mechanisms of ALF and ACLF,standard medical therapy remains the primary therapeutic approach.Liver transplantation(LT)is considered the last option,and in several cases,it is the only intervention that can be lifesaving.Unfortunately,this intervention is limited by organ donation shortage or exclusion criteria such that not all patients in need can receive a transplant.Another option is to restore impaired liver function with artificial extracorporeal blood purification systems.The first such systems were developed at the end of the 20th century,providing solutions as bridging therapy,either for liver recovery or LT.They enhance the elimination of metabolites and substances that accumulate due to compromised liver function.In addition,they aid in clearance of molecules released during acute liver decompensation,which can initiate an excessive inflammatory response in these patients causing hepatic encephalopathy,multiple-organ failure,and other complications of liver failure.As compared to renal replacement therapies,we have been unsuccessful in using artificial extracorporeal blood purification systems to completely replace liver function despite the outstanding technological evolution of these systems.Extracting middle to high-molecular-weight and hydrophobic/protein-bound molecules remains extremely challenging.The majority of the currently available systems include a combination of methods that cleanse different ranges and types of molecules and toxins.Furthermore,conventional methods such as plasma exchange are being re-evaluated,and novel adsorption filters are increasingly being used for liver indications.These strategies are very promising for the treatment of liver failure.Nevertheless,the best method,system,or device has not been developed yet,and its probability of getting developed in the near future is also low.Furthermore,little is known about the effects of liver support systems on the overall and transplant-free survival of these patients,and further investigation using randomized controlled trials and meta-analyses is needed.This review presents the most popular extracorporeal blood purification techniques for liver replacement therapy.It focuses on general principles of their function,and on evidence regarding their effectiveness in detoxification and in supporting patients with ALF and ACLF.In addition,we have outlined the basic advantages and disadvantages of each system. | Panagiotis Papamichalis Katerina G Oikonomou Asimina Valsamaki Maria Xanthoudaki Periklis Katsiafylloudis Evangelia Papapostolou Apostolia-Lemonia Skoura Michail Papamichalis Marios Karvouniaris Antonios Koutras Eleni Vaitsi Smaragdi Sarchosi Antonios Papadogoulas Dimitrios Papadopoulos | 2023 | World Journal of Clinical Cases2023，11，17： | 0 |
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