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| 1 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 2 | Efficacy and safety of loopdiuretic therapy in acute decompensated heart failure : a clinicalreview显示文摘 | Leto L Aspromonte N Feola M | 2014 | Heart Fail Rev2014，19，： | 1 |
| 3 | FTIR studies of butane,toluene and nitric oxide adsorption on Ag exchanged NaMordenite显示文摘 | Aspromonte S G Miró E E Boix A V | 2012 | Adsorption2012，18，1： | 1 |
| 4 | B-type natriuretic peptide can predict the medium-term risk in patients with acute heart failure and preserved systolic function显示文摘 | Valle R Aspromonte N Feola M | 2005 | J Card Fail2005，11，7： | 1 |
| 5 | How often we need to measure brain natriuretic peptide(BNP) blood levels in patients ad- mined to the hospital for acute severeheart failure Role of serial meas- urements to improve short-term prognostic stratification显示文摘 | FAGGIANO P VALLE R ASPROMONTE N | 2010 | Int J Car- dio12010，140，1： | 1 |
| 6 | Diagnosis and Management of Fluid Overload in Heart Failure and Cardio-Renal Syndrome: The “5B” Approach显示文摘 | Claudio Ronco Manish Kaushik Roberto Valle Nadia Aspromonte W. Frank Peacock | 2012 | Seminars in Nephrology2012，，1： | 1 |
| 7 | Epidemiology ofcardiorenal syndromes: workgroup statements from the 7th ADQIConsensus Conference显示文摘 | Bagshaw SM Cruz DN Aspromonte N | 2010 | Nephrol Dial Transplant2010，25，5： | 1 |
| 8 | Management and monitoring of haemodynamic complications in acute heart failure显示文摘 | Aspromonte N Cruz DN Valle R | 2011 | Heart Fail Rev2011，16，6： | 1 |
| 9 | Epidemiology of cardio-renal syndromes:workgroup statements from the 7th ADQI consensus conference 显示文摘 | Bagshaw SM Cruz DN Aspromonte N | 2010 | Nephrol Dial Transplant2010，25，： | 1 |
| 10 | Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative显示文摘 | Ronco C McCullough P Anker S D Anand I Aspromonte N Bagshaw S M | 2010 | Eur Heart J2010，31，： | 1 |
| 11 | Early diagnosis of congestive heart failure clinical utility of:B-type natriuretic peptide testing associated with Doppler echocardiography显示文摘 | Aspromonte N Feola M Scardovi A B | 2006 | J Cardiovasc Med(Hagerstown)2006，7，6： | 1 |
| 12 | Metabolic and toxicologicalconsiderations for diuretic therapy in patients with acute heartfailure显示文摘 | Aspromonte N Cruz DN Valle R | 2011 | Expert Opin Drug Metab Toxicol2011，7，9： | 1 |
| 13 | How often we need to measure brain natriuretic peptide (BNP) blood lev-els in patients admitted to the hospital for acute severe heart failure? Role of serial measurements to improve short-term prognostic stratification 显示文摘 | Faggiano P Valle R Aspromonte N | 2010 | Int J C ardiol2010，140，1： | 1 |
| 14 | How often we need to measure brain natriuretic peptide (BNP) blood levels in patients ad- mitted to the hospital for acute severe heart failure? Role of serial measurements to improve short- term prognostic stratification显示文摘 | Faggiano P Valle R Aspromonte N | 2010 | Int J Cardiol2010，140，1： | 1 |
| 15 | Early diagnosis of congestive heart failure: clinical utility of B-type natriuretic peptide testing associated with Doppler echocardiography 显示文摘 | Aspromonte N Feola M Scardovi A B | 2006 | J Cardiovasc Med (Hagerstown)2006，7，6： | 1 |
| 16 | How often we need to measure brain natriuretic peptide (BNP) blood levels in patients admitted to the hospital for acute severe heart failure? Role of serial measurements to improve short-term prognostic stratification显示文摘 | FAGGIANO P VALLE R ASPROMONTE N | 2010 | Int J Cardiol2010，140，1： | 1 |
| 17 | Deactivation studies of the SCR of NOx with hydrocarbons on Co-mordenite monolithic catalysts显示文摘 | BOIX A V ASPROMONTE S G MIRO E E | 2008 | Appl Catal A2008，341，12： | 1 |
| 18 | Brain natriuretic peptide plasma level is a reliable indicator of advanced diastolic dysfunction in patients with chronic heart failure 显示文摘 | Scardovi AB Coletta C Aspromonte N | 2007 | Eur J Echocardiogr2007，8，1： | 1 |
| 19 | Epidemiology of cardio-renal syndromes: workgroup statements from the 7th ADQI Consensus Conference显示文摘 | BAGSHAW S M CRUZ D N ASPROMONTE N | 2010 | Nephrol Dial Transplant2010，25，5： | 1 |
| 20 | Fall in readmission rate for heart failure after implementation of B-type natriuretic peptide testing for discharge decision:a retrospective study显示文摘 | Valle R Aspromonte N Carbonieri E | | 0，，03： | 1 |
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