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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | Association of estimated glomerular filtration rate and albuminuria with all cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis显示文摘 | Matsushita K van der Velde M Astor B C | 2010 | Lancet2010，375，9731： | 1 |
| 3 | Prevalence of chronic Kidney Disease and decreased kidney function in the adult US population:Third National Health and Nutrition Examination Surrey显示文摘 | Coresh J Astor B C Greene T | 2003 | Am J Kidney Dis2003，41，1： | 1 |
| 4 | Parotid surgery using Nd:YAG laser contact tips:clinical assessment of perioperative facial nerve function显示文摘 | ASTOR F C HANFT K L | 2003 | J Clin Laser Med Surg2003，21，5： | 1 |
| 5 | International comparison of therelationship of chronic kidney disease prevalence and ESRD risk显示文摘 | Hallan S I Coresh J Astor B C | 2006 | J AmSoc Nephrol2006，17，8： | 1 |
| 6 | Prevalence of chronic kidney disease and decreased kidney function in the aduit US popula- tion:Third National Health and Nutrition Examination Survey显示文摘 | Coresh J Astor B C Greene T et aI | 2003 | Am J Kidney Dis2003，41，： | 1 |
| 7 | Blood pressure, atherosclerosis, and albuminuria in 10 113 participants in the Atherosclerosis Risk In Communities study显示文摘 | Charles C Hsu Frederick L Brancati Brad C Astor Wen Hong Kao Michael W Steffes Aaron R Folsom Josef Coresh | 2009 | Journal of Hypertension2009，，2： | 1 |
| 8 | Trefoil factor 3 predicts incident chronic kidney disease : a case-control study nested with- in the atherosclerosis risk in communities (ARIC) study显示文摘 | Astor B C Kttgen A Coresh J | 2011 | Am J Nephrol2011，34，4： | 1 |
| 9 | Changes in physical fimess parameters during a competitive field hockey season 显示文摘 | ASTOR/NO TODD A TAM PETER A RIETSCHEL JEREMY C | 2004 | J Strength and Conditioning Research2004，18，4： | 1 |
| 10 | Blood pressure and chronic kidney disease progression in a multi-racial cohort:the multi-ethnic study of atherosclerosis显示文摘 | Bloomfield G S Yi S S Astor B C | 2013 | J Hum Hypertens2013，27，7： | 1 |
| 11 | Chronic kidney disease awareness, prevalence, and trends among US adults, 1999 to 2000显示文摘 | Coresh J Byrd-Hoh D Astor B C | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 12 | Prevalence of chronic kidney disease and decreased kidney function in the adult US显示文摘 | Coresh J Astor B C Greene T | 2003 | Am J KidneyDis2003，41，1： | 1 |
| 13 | Novel and traditional cardiovascular risk factors for peripheral arterial disease in incidentdialysis patients 显示文摘 | Jaar B G Plantinga L C Astor B C | 2007 | Adv Chronic Kidney Dis2007，14，3： | 1 |
| 14 | Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey显示文摘 | Coresh J Astor B C Greene T | 2003 | Am J Kidney Dis2003，41，1： | 1 |
| 15 | Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey显示文摘 | Coresh J Astor B C Greene T | 2003 | Am J Kidney Dis2003，41，1： | 1 |
| 16 | Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994) 显示文摘 | ASTOR B C MUNTNER P LEVIN A | 2002 | Arch Intern Med2002，162，12： | 1 |
| 17 | Association of estimated glomerular filtra- tion rate and albuminuria with all-cause and cardiovas- cular mortality in general population cohorts: a col- laborative meta-analysis 显示文摘 | MATSUSHITA K VAN DER VELDE M ASTOR B C | 2010 | Lancet2010，375，： | 1 |
| 18 | Association of estimated glomerular filtration rate and albuminuria with all - cause and cardiovascular mortality in general population cohorts:a collaborative meta - analysis显示文摘 | MATSUSH1TA K VAN DER VELDE M ASTOR B C | 2010 | The Lancet2010，375，20： | 1 |
| 19 | Transgenic tobacco plants co expressing agrobacterium iaa and ipt genes have wild-type hormone levels, but display both auxin- and cytokinin- overproducing phenotypes 显示文摘 | Ekloef S Astor C Sitbon F | 2000 | The Plant Journal2000，23，： | 1 |
| 20 | Prevalence of chronic kidney disease and decreased kidney function in the aduit US popula-tion:Third National Health and Nutrition Examination Survey显示文摘 | Coresh J Astor B C Greene T | | 0，，： | 1 |
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