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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons显示文摘AIM To determine the level of consensus on the definition of colorectal anastomotic leakage(CAL) among Dutch and Chinese colorectal surgeons.METHODS Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL,and regarding clinical and radiological diagnosis of the complication.RESULTS Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: ‘extravasation of contrast medium after rectal enema on a CT scan'. Another two were found relevant according to Dutch surgeons: ‘necrosis of the anastomosis found during reoperation',and ‘a radiological collection treated with percutaneous drainage'. No consensus was found for all other proposed elements that may be included in a general definition.CONCLUSION There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report ‘subclinical' leaks as CAL,which partly explains the higher reported Dutch CAL rates. | Stefanus J van Rooijen Audrey CHM Jongen Zhou-qiao Wu Jia-fu Ji Gerrit D Slooter Rudi MH Roumen Nicole D Bouvy | 2017 | World Journal of Gastroenterology2017，23，33： | 4 |
| 3 | Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study显示文摘BACKGROUND Despite the emerging knowledge about colorectal anastomotic leakage(CAL)through the increasing number of clinical and experimental studies, there is no generally accepted definition of CAL. Because of the wide variety of definitions used in literature, comparison of study outcomes and quality of care is complicated.AIM To reach consensus on the definition of CAL using a modified Delphi method.METHODS The RAND/UCLA appropriateness method was used. The expert panel consisted of international colorectal surgeons and researchers who had published three or more articles about CAL. The consensus process consisted of two online distributed questionnaires and a third round with a recommendation. In the questionnaires participants were asked to rate the appropriateness of statements using a 1-9 Likert scale. Consensus was defined as a panel median between 1-3 or 7-9 without disagreement. In the final round a recommendation was formed regarding the definition of CAL and the expert panel was asked if they agreed or disagreed.RESULTSTwenty-three authors participated in the first round and twenty-one finished the second round. After two rounds consensus was reached on 37 items(80%) in nine different categories. The International Study Group of Rectal Cancer definition is the most frequently advised general definition by our panel. Consensus was reached regarding the clinical symptoms of CAL, which serum markers contributes to the suspicion of CAL, which radiological and perioperative findings should be considered as CAL, which grading system is appropriate and if there should be a range of postoperative days in the definition. Eventually, 19 experts completed all three rounds of which 16(84%) agreed with our final recommendations for the definition of CAL.CONCLUSION A consensus-based recommendation for the definition of CAL was formed using our modified Delphi method that can be widely incorporated in the field. | Claire PM van Helsdingen Audrey CHM Jongen Wouter J de Jonge Nicole D Bouvy Joep PM Derikx | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | Impact of aerobic exercise training on Heart Rate Variability and functional capacity in obese women after gastric bypass sur- gery显示文摘 | CASTELLO V BASSI D AUDREY BORGHI-SILVA | 2011 | Obes Surg2011，21，： | 1 |
| 5 | An expanded view of inositol signaling 显示文摘 | York John D Guo Shuling Odom Audrey | 2001 | Advances in Enzyme Regulation2001，41，1： | 1 |
| 6 | Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone显示文摘 | Audrey A D Menno B C Warnerie J | 2002 | Journal of Controlled Release2002，78，： | 1 |
| 7 | Design of segmented poly(ether ester)materials and structures for the tissue engineering of bone显示文摘 | Audrey A D Menno B C WarnerieJ | 2002 | Journal of Controlled Release2002，78，： | 1 |
| 8 | An ex- panded view of inositol signaling 显示文摘 | York John D Guo Shuling Odom Audrey | 2001 | Advances in En- zyme Regulation2001，41，1： | 1 |
| 9 | Effect of homologous and heterologous prime boost on the immune response to recombinant plague antigens显示文摘 | Audrey G Lucy C F John D | 2005 | Vaccine2005，23，： | 1 |
| 10 | An ex- panded view of inositol signaling 显示文摘 | York John D Guo Shuling Odom Audrey | 2001 | Advances in En- zyme Regulation2001，，1： | 1 |
| 11 | Wastewater reclamation, recycling and reuse:past, present and future 显示文摘 | Takashi A Audrey D L | 1996 | Wat Sci Tech1996，33，1011： | 1 |
| 12 | Wastewater rec|amation recycling and reuse: Past, present, and future 显示文摘 | Takashi A Audrey D Levine | 1996 | Water Science Technology1996，33，1011： | 1 |
| 13 | Wastewater reclamation, recycling and reuse: past, present, and future显示文摘 | Takashi Asano Audrey D Levine | 1996 | Water Science and Technology1996，33，10： | 1 |
| 14 | Effects of ascorbic acid, glutathione, thiocyanate, and iodide on antimJcrobial activity of acidi- fied nitrite显示文摘 | ALEMU F ROLF D AUDREY L | 2004 | Antimicrobial Agents and Chemotherapy2004，48，2： | 1 |
| 15 | Determina- tion of Pre-impact Occupant Postures and Analysis of Conse- quences on Injury Outcome-Part II: Biomechanical Study显示文摘 | AUDREY H D FREDERIC R PASCAL D | 2011 | Accident Analysis and Prevention2011，43，1： | 1 |
| 16 | Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice显示文摘 | BARBARA D P AUDREY M N LOUISE D | 2010 | J Nutr2010，140，3： | 1 |
| 17 | First report of Spring viremia of carp virus (SVCV) in wild common carp in North America显示文摘 | Audrey L D Craig R Kathy T K | 2004 | J Aquatic Animal Health2004，16，： | 1 |
| 18 | Kawasaki syndrome 显示文摘 | Dorothy W Wortmann M D Audrey W | 1990 | Rheum Dis Clin Nor Am1990，16，2： | 1 |
| 19 | Gene expression changes during asexual sporulation by the late blight agent Phytophthora infestans occur in discrete temporal stages显示文摘 | Howard S J Reena D N Audrey M V | 2009 | Molecular Genetics and Genomics2009，2，281： | 1 |
| 20 | An expanded view of inositol signaling 显示文摘 | York John D Guo Shuling Odom Audrey | 2001 | A dv Enzyme Regular2001，41，1： | 1 |
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