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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Wheat- gluten uses and indus- try needs 显示文摘 | Day L Augustin M A Batey I | 2006 | Food Science and Technology2006，17，： | 1 |
| 3 | Production of Calcium-fortified Milk Powders using Soluble Calcium Salts 显示文摘 | WILLIAMS R P W D'Ath L and AUGUSTIN M A | 2005 | Lait2005，85，45： | 1 |
| 4 | In vitro lipolysis of fish oil microcapsules containing protein and resistant starch 显示文摘 | Chung C Sanguansri L Augustin M A | 2011 | Food Chemistry2011，124，： | 1 |
| 5 | Laboratory and numerical studies of wave damping by emergent and near-emergent wetland vegetation 显示文摘 | Augustin L N Irish J L Lynett P | 2009 | Coastal Engineering2009，56，3： | 1 |
| 6 | Human resource systems and sustained competitive advantage : A competency - based perspective 显示文摘 | AUGUSTINE A L M C W | 1994 | A- cademy of Management Review1994，19，4： | 1 |
| 7 | Identification and characterization of human glucose transporter - like protein - 9 ( GLUT9 ) : alternative splicing alters trafficking 显示文摘 | AUGUSTIN R CARAYANNOPOULOS M O DOWD L O | 2004 | J Biol Chem2004，279，16： | 1 |
| 8 | Laboratory and numerical studies of wave damping by emergent and near- emergent wetland vegetation 显示文摘 | Augustin L N Irish J L Lynett P | 2009 | Coastal Engineering2009，56，3： | 1 |
| 9 | Intracranial Aneurysms:Recurrences More than 10 Years after Endovascular Treatment-A Prospective Cohort Study,Systematic Review,and Meta-Analysis显示文摘 | Augustin L Jean R Christine R R | 2015 | Radiology2015，277，1： | 1 |
| 10 | The EPICA deep drilling program 显示文摘 | Augustin L Antonelli A | 2002 | Memoirs of National Institute of Polar Research Special issue2002，56，： | 1 |
| 11 | In-vitro evaluation of hydrocolloid-based encapsulated fish oil 显示文摘 | Kosaraju S L Weerakkody R Augustin M A | 2009 | FoodHydrocolloids2009，23，5： | 1 |
| 12 | Induction of hepatobiliary efflux transporters in acetaminophen- induced acute liver failure cases显示文摘 | Barnes SN Aleksunes LM Augustine L | 2007 | Drug Metab Dispos2007，35，10： | 1 |
| 13 | Female flower induction on androecious cucumber, Cucumis sativus 显示文摘 | Augustine J J Baker L R Sell H M | 1973 | Journal of American Society For Horticultural Science1973，98，： | 1 |
| 14 | Combustion synthesis and characterization of Sn4+ substituted nanocrystalline NiFe204显示文摘 | BALAJI S KALAI SELVAN R JOHN BERCHMANS L ANGAPPAN S SUBRAMANIAN K AUGUSTIN C O | 2005 | Materials Science Engineering B2005，119，2： | 1 |
| 15 | Viscous dietary fiber and metabolic effects显示文摘 | Jenkins D J A Marchie A Augustin L S A et ol | 2004 | Clinical Nutrition Supplements2004，1，2： | 1 |
| 16 | A model describing the effect of temperature history on lag time for Listeria monocytogenes 显示文摘 | Augustin J C Rosso L Carlier V | 2000 | International Journal of Food Microbiology2000，57，3： | 1 |
| 17 | Resistant starch and health 显示文摘 | Kendall C W C Fanam A Augustin L S A | 2004 | Journal of AOAC International2004，87，3： | 1 |
| 18 | Wheat gluten uses and industry needs显示文摘 | Day L Augustin M A Batey I L | 2006 | Trends in Food Science and Technology2006，，17： | 1 |
| 19 | Noise triggering of radiation damping from the inverted state显示文摘 | Augustine M P Bush S D Hahn E L | 2000 | Chem Phys Lett2000，322，： | 1 |
| 20 | Wheat- gluten uses and industry needs 显示文摘 | Day L Augustin MA Batey IL | 2006 | Food Science and Technology2006，17，2： | 1 |
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