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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Perspectives damelioration genetique des peupliers en France显示文摘 | Villar M Lefevre F Augustin S | 1995 | Comptes Rendus de I′Academie d′Agriculture de France1995，81，3： | 2 |
| 4 | Wheat- gluten uses and indus- try needs 显示文摘 | Day L Augustin M A Batey I | 2006 | Food Science and Technology2006，17，： | 1 |
| 5 | Protective immunization against the intestinal parasite Eimeria accervulina with recombinant coccidial against antigen显示文摘 | Jenkins M C Siberian P C Augustine P C | 1991 | Poultry Science1991，70，： | 1 |
| 6 | Mineral and casein equilibria in milk: effects of added salts and calcium-chelating agents显示文摘 | AUGUSTIN M | 2000 | Journal of Dairy Research2000，67，3： | 1 |
| 7 | A facile way to control the number of walls in carbon nanotubes through the synthesis of exposed-core/shell catalyst nanoparticles 显示文摘 | ChoiK M AugustineS ChoiJH etal | 2008 | Angewandte Chemic2008，120，： | 1 |
| 8 | B7-H4 deficient mice display augmented neutrophil-mediated innate immunity显示文摘 | Zhu G Augustine M M Azuma T | 2009 | Blood2009，113，8： | 1 |
| 9 | Nail assessment in psoriasis and psoriatic arthritis (NAPPA): development and validation of a tool for assessment of nail psoriasis outcomes 显示文摘 | Augustin M Blome C Costanzo A | 2014 | The British journal of dermatology2014，170，3： | 1 |
| 10 | Improved diffusionweighted single-shot echo-planar imaging (EPI) in stroke using sensitivity encoding (SENSE)显示文摘 | Bammer R Keellng SL Augustin M | 2001 | Magn Reson Med2001，46，3： | 1 |
| 11 | Protective Immunity against coccidiosis elicited by radiationattenuated Eimeria maxima porosities that are incapable of asexual development显示文摘 | Jenkins M C Siberian P C Augustine P C | 1993 | Avian Disease1993，37，： | 1 |
| 12 | Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis 显示文摘 | Bammer R Augustin M Strasser-Fuchs S | 2000 | Magn Reson Med2000，44，4： | 1 |
| 13 | Effect of TBHQ on quality charac- teristics of RBD olein during frying 显示文摘 | Asap T Augustin M A | 1986 | Journal of the A- merican Oil Chemists'' Society1986，63，9： | 1 |
| 14 | Enzymatic ver- sus autolytic debridement of chronic leg ulcers: a prospec- tive randomised trial 显示文摘 | Knig M Vanscheidt W Augustin M | 2005 | J Wound Care2005，14，7： | 1 |
| 15 | Numerical simulation of the fouling process显示文摘 | BRAHIM F AUGUSTIN W BOHNET M | 2003 | International Journal of Thermal Sciences2003，42，5： | 1 |
| 16 | Influence of oak wood and grape tannins on the lactic acid bacterium Oenococcus oeni (Leuconostoc oenos 8413) 显示文摘 | Vivas N Augustin M Lonvaud- Funel A | 2000 | Journal of the Science of Food and Agriculture2000，80，11： | 1 |
| 17 | Production of Calcium-fortified Milk Powders using Soluble Calcium Salts 显示文摘 | WILLIAMS R P W D'Ath L and AUGUSTIN M A | 2005 | Lait2005，85，45： | 1 |
| 18 | Photodynamic therapy for symptomatic choroidal hemangioma显示文摘 | Ursula M Schmidt-Erfurth Stephan Michels Christine Kusserow Bernhard Jurklies Albert J Augustin | 2002 | Ophthalmology2002，，12： | 1 |
| 19 | In vitro lipolysis of fish oil microcapsules containing protein and resistant starch 显示文摘 | Chung C Sanguansri L Augustin M A | 2011 | Food Chemistry2011，124，： | 1 |
| 20 | Influence of the adhesion force crystal/heat exch-anger surface on fouling mitigation显示文摘 | Forster M Augustin W | 1999 | Chemical Engineering and Processing:Process Intens-ification1999，38，4： | 1 |
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