| 5 | Low cholesterol biosynthesis favors epithelial-to-mesenchymal transition maintenance and influences tumor molecular subtyping and disease-free survival in colon cancer patients显示文摘Dear Editor,To metastasize,epithelial cancer cells undergo an epithelial-to-mesenchymal transition(EMT)during migration,whereupon they activate a mesenchymal-toepithelial transition(MET)when colonizing the new niche[1].Targeting EMT or MET inducers might thus impair the metastatic process[2,3].However,the identification of genes involved in epithelium-mesenchyme switches(EMS)is difficult in complex samples such as human tumors.To overcome this problem,we used spheroids of a colorectal cancer(CRC)cell line,HT29,to mimic EMS in a controlled environment. | Anaïs Aulas Maria Lucia Liberatoscioli Pascal Finetti Olivier Cabaud David JBirnbaum Lucas Usclade Daniel Birnbaum François Bertucci Emilie Mamessier | 2022 | Cancer Communications2022，42，8： | 0 |
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