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	题名	作者	年代	出处	被引量
1	Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.	Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust	2008	World Journal of Gastroenterology2008，14，7：	29
2	On a More Restrictive Geometric Criterion for 'Special' CSL Grain Boundaries显示文摘	Palumbo G Aust K T Lehockey E M	1998	Scr Mater1998，38，11：	1
3	Intergranular Corm sion and Mechanical Properties of Austenitic Stainless Steels显示文摘	Aust K T Armiio J S Koch E F	1968	AsmTransQuart1968，61，：	1
4	Corrosion and auger studies of a nickel-base matalmetalloid glass: ( 显示文摘	THORPE S J RAMASWAMNI B AUST E T	1988	J Electro Chem Soc1988，135，9：	1
5	Concrete filled steel tubular columns显示文摘	Bridge R Q AUST M I E	1976	Civil Engineering Transactions1976，18，2：	1
6	On a More Restrictive Geometric Criterion for 'Special' CSL Grain Boundaries 显示文摘	Palumbo G Aust K T Lehockey E M	1998	Scr Mater1998，38，11：	1
7	Howthe anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen:X-ray structures for two Fab'/hapten complexes with different metals in the chelate显示文摘	Love R A Villafranca J E Aust R M	1993	Biochemistry1993，32，10：	1
8	On a more restrictive geometric criterion for ' Special' CSL grain boundaries 显示文摘	Palumbo G Aust K T Lehockey E M	1998	Scripta Materialia1998，38，11：	1
9	Superoxide-and singlet oxygen-catalyzed lipid peroxidation as a possi-ble mechanism for paraquat(methyl viologen)toxicity显示文摘	BUS J S AUST S D GIBSON J E	1974	Biochem Biophys Res Commun1974，58，：	1
10	Metal injection moulding of gamma titanium aluminide ahoy powder 显示文摘	Gerling R Aust E Limberg W	2006	Materials Science and Engineering A2006，423，：	1
11	Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria 显示文摘	Aust D E Baretton G B	2010	Virchows Arch2010，457，3：	1
12	Solute Induced Hardening near Grain Boundaries in Zone Refined Metals 显示文摘	Aust K T Hanneman R E Niessen P	1968	Acta Metall1968，16，3：	1
13	How the anti-(metal chelate)antibody CHA255 is specific for the metalion of its antigen: X-ray structures for two fab’/haptencomplexes with different metals in the chelate显示文摘	Love R A Villafranca J E Aust R al	1993	Bio-chemistry1993，32，10：	1
14	On a more restrictive geometric criterion for ‘special' CSL grain boundaries显示文摘	Palumbo G Aust K T Lehockey E M	1998	Scri Mater1998，38，11：	1
15	Solute Induced Harding Near Grain Boundaries in Zone Refined Metals 显示文摘	Aust K T Hanneman R E Niessen P	1968	ActaMetall1968，16，：	1
16	How the anti- (metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two fab/hapten complexes with different metals in the chelate显示文摘	Love R A Villafranca J E Aust R M	1993	Biochemistry1993，32，10：	1
17	Ferritin and superoxide-dependent lipid peroxidation显示文摘	Thomas C E Morehouse L A Aust S D	1985	J Biol Chem1985，260，6：	1
18	Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation显示文摘	Rahmani M Aust MM Hawkins E et at	2015	Haematologica2015，100，12：	1
19	Postischemic tissue injury by ironmediated free radical liplid peroxidetion显示文摘	White B C Aust S D Arfors K E	1985	Ann Emery Med1985，14，：	1
20	Serrated polyps of the colon and rec tum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps) proposal for diagnostic criteria显示文摘	Aust D E Baretton G B	2010	Virchows Arch2010，457，3：	1

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