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| 1 | Changes in colorectal cancer incidence rates in young and older adults in the United States: what does it tell us about screening显示文摘 | Harland Austin S. Jane Henley Jessica King Lisa C. Richardson Christie Eheman | 2014 | Cancer Causes & Control2014，，2： | 2 |
| 2 | Atherogenic lipoprotein phenotype: a proposed genetic marker for coronary heart dissease risk 显示文摘 | Austin MA King MC Vranizan KM | 1990 | Circulation1990，82，： | 1 |
| 3 | Atherogeniclipo-protein phenotypela proposed genetic marker for coronary heart disease risk 显示文摘 | Austin M A King M C | 1990 | Circulation1990，82，： | 1 |
| 4 | Changes in colorectal cancer in- cidence rates in young and older adults in the United States: what does it tell us about screening显示文摘 | Austin H Jane H S King J el al | 2014 | Cancer Causes CunIrul2014，25，2： | 1 |
| 5 | Arteriogenic lipoprotein phenotype:a proposed genetic marker for coronary heart disease risk 显示文摘 | Austin MA King MC Vranizan KM | 1990 | Circulation1990，82，1： | 1 |
| 6 | Arteriogenic lipoprotein phenotype:a proposed genetic marker for coronary heart disease risk显示文摘 | King MC Vranizan KM | 2001 | Circulation2001，82，： | 1 |
| 7 | Atherogeniclipo prolein phenotypela proposed genetic marker for coronary heart disease risk显示文摘 | Austin M A King M C | 1990 | Circulation1990，82，： | 1 |
| 8 | Some characteristics of roll-type uranium deposits at Gas Hills, Wyoming: US显示文摘 | King J W Austin S R | 1966 | Mining Engineers1966，18，5： | 1 |
| 9 | Atherogenic Lipoprotein Phenotype: A Proposed Genetic Marker for Coronary Heart Disease Risk显示文摘 | Melissa A. Austin Mary-Claire King Karen M. Vranizan Ronald M. Krauss | 1990 | Circulation1990，，2： | 1 |
| 10 | Athero- genic lipoprotein phenotype: a proposed genetic marker for coronary heart disease risk显示文摘 | Austin M A King M C Vranizan K M | 1990 | Circulation1990，82，2： | 1 |
| 11 | Atherogeniclipo-protein phenotypela proposed genetic marker for coronary heart disease risk 显示文摘 | Austin M A King M C | 1990 | Circulation1990，82，： | 1 |
| 12 | 用空间和材料对抗沙漠酷热——加利福尼亚州拉金塔麦迪逊住宅显示文摘麦迪逊住宅坐落于一个小圆丘上,正对着加利福尼亚州拉金塔的圣罗莎山。与此同时,棕榈泉距离它的东面仅30英里,这一地区在历史上被称为马的王国,周围到处是马厩、田野和群山。当地的小气候具有双重特点:一方面夏季气温炎热但风大;另一方面冬季温度适中,自然景色美丽壮观。麦迪逊住宅的设计便综合考虑了该地区气候的双重性。 | Austin Kelly AIA Monika Haefelfinger SIA Scott Utterstrom Tina Rothermund Jae Rodriguez Qichen Cao Christina Kaneva Dana Nishimura Bryan Stephanie Sent Jeremy Bitterman Steve King Art Gray | 2015 | 设计家2015，，1： | 0 |
| 13 | Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data:a multi-phased study of prostate cancer显示文摘Background:DNA methylation and gene expression are known to play important roles in the etiology of human diseases such as prostate cancer(PCa).However,it has not yet been possible to incorporate information of DNA methylation and gene expression into polygenic risk scores(PRSs).Here,we aimed to develop and validate an improved PRS for PCa risk by incorporating genetically predicted gene expression and DNA methylation,and other genomic information using an integrative method.Methods:Using data from the PRACTICAL consortium,we derived multiple sets of genetic scores,including those based on available single-nucleotide polymorphisms through widely used methods of pruning and thresholding,LDpred,LDpred-funt,AnnoPred,and EBPRS,as well as PRS constructed using the genetically predicted gene expression and DNA methylation through a revised pruning and thresholding strategy.In the tuning step,using the UK Biobank data(1458 prevalent cases and 1467 controls),we selected PRSs with the best performance.Using an independent set of data from the UK Biobank,we developed an integrative PRS combining information from individual scores.Furthermore,in the testing step,we tested the performance of the integrative PRS in another independent set of UK Biobank data of incident cases and controls.Results:Our constructed PRS had improved performance(C statistics:76.1%)over PRSs constructed by individual benchmark methods(from 69.6%to 74.7%).Furthermore,our new PRS had much higher risk assessment power than family history.The overall net reclassification improvement was 69.0%by adding PRS to the baseline model compared with 12.5%by adding family history.Conclusions:We developed and validated a new PRS which may improve the utility in predicting the risk of developing PCa.Our innovative method can also be applied to other human diseases to improve risk prediction across multiple outcomes. | Chong Wu Jingjing Zhu Austin King Xiaoran Tong Qing Lu Jong Y.Park Liang Wang Guimin Gao Hong-Wen Deng Yaohua Yang Karen E.Knudsen Timothy R.Rebbeck Jirong Long Wei Zheng Wei Pan David V.Conti Christopher A Haiman Lang Wu | 2021 | Cancer Communications2021，41，12： | 0 |
| 14 | 产能分散大潮即将来袭显示文摘总部位于美国加利福尼亚的芯片制造商格芯(Globalfoundries Inc.)今年8月对竞争对手台湾积体电路制造有限公司(Taiwan Semiconductor Manufacturing Co.)发起专利诉讼时,它利用了人们曰益增长的担忧,即未来芯片市场上的竞争会循着严峻的地缘政治战线展开。 | Austin Carr Ian King 李译(译) | 2019 | 商业周刊(中文版)2019，0，23： | 0 |
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