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| 1 | Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy:A review of the literature and critical reappraisal of the implicated pathomechanism显示文摘Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the effi cacy of a recently reported (but not yet tested in large- scale studies) modifi cation, that is, PPPD with antecolic duodenojejunostomy. | Kosmas I Paraskevas Costas Avgerinos Costas Manes Dimitris Lytras Christos Dervenis | 2006 | World Journal of Gastroenterology2006，12，37： | 16 |
| 2 | Incidence and risk factors for the development of anemia following gastric bypass surgery显示文摘AIM:To evaluate the incidence and risk factors for the development of anemia after RouxenY gastric bypass (RYGB).METHODS: A retrospective analysis of patients undergoing RYGB from January 2003 to November 2007 was performed. All patients had a preoperative body mass index > 40 kg/m2. A total of 206 patients were evaluated. All patients were given daily supplements of ferrous sulfate tablets for 2 wk following their operation. Hematological and metabolic indices were routinely evaluated following surgery. Patients were followed for a minimum of 86 wk.RESULTS: There were 41 males and 165 females with an average age of 40.8 years. 21 patients (10.2%) developed postoperative anemia and 185 patients (89.8%) did not. Anemia was due to iron deficiency in all cases. The groups had similar demographics, surgical procedure and comorbidities. Menstruation (P = 0.02) and peptic ulcer disease (P = 0.01) were risk factors for the development of postoperative anemia.CONCLUSION: Iron deficiency anemia is frequent. RYGB surgery compounds occult blood loss. Increased ferrous sulfate supplementation may prevent iron depletion in populations at increased risk. | Dimitrios V Avgerinos Omar H Llaguna Matthew Seigerman Amanda J Lefkowitz I Michael Leitman | 2010 | World Journal of Gastroenterology2010，16，15： | 6 |
| 3 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 4 | Molecular aspects of carcinogenesis in pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer(PCa)is one of the most aggressive human solid tumors,with rapid growth and metastatic spread as well as resistance to chemotherapeutic drugs,leading rapidly to virtually incurable disease.Over the last 20 years,however,significant advances have been made in our understanding of the molecular biology of PCa,with a focus on the cytogenetic abnormalities in PCa cell growth and differentiation. DATA SOURCES:A MEDLINE search and manual cross- referencing were utilized to identify published data for PCa molecular biology studies between 1986 and 2008, with emphasis on genetic alterations and developmental oncology. RESULTS:Activation of oncogenes,deregulation of tumor suppressor and genome maintenance genes,upregulation of growth factors/growth factor receptor signaling cascade systems,and alterations in cytokine expression,have been reported to play important roles in the process of pancreatic carcinogenesis.Alterations in the K-ras proto- oncogene and the p16INK4a,p53,FHIT,and DPC4 tumor suppressor genes occur in a high percentage of tumors. Furthermore,a variety of growth factors are expressed at increased levels.In addition,PCa often exhibits alterations in growth inhibitory pathways and evades apoptosis through p53 mutations and aberrant expression of apoptosis-regulating genes,such as members of the Bcl family.Additional pathways in the development of an aggressive phenotype,local infiltration and metastasis are still under ongoing genetic research.The present paper reviews recent studies on the pathogenesis of PCa,and includes a brief reference to alterations reported for other types of pancreatic tumor. CONCLUSIONS:Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa.However,further studies are needed to better understand the fundamental changes that occur in PCa,thus leading to better diagnostic and therapeutic management. | Alexandros Koliopanos Constantinos Avgerinos Constantina Paraskeva Zisis Touloumis Dionisisa Kelgiorgi Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 4 |
| 5 | Radical resection of pancreatic cancer显示文摘BACKGROUND: Pancreatic adenocarcinoma (PCa) is a disease with dismal prognosis, and the only possibility of cure, albeit small, is based on the combination of complete resection with negative histopathological margins (R0 resection) with adjuvant treatment. Therefore, a lot of effort has been made during the last decade to assess the role of extensive surgery in both local recurrence and survival of patients with PCa. DATA SOURCES: Medline search and manual cross- referencing were utilized to identify published evidence- based data for PCa surgery between 1973 and 2006, with emphasis to feasibility, efficacy, long-term survival, disease free survival, recurrence rates, pain relief and quality of life. RESULTS: Extended surgery is safe and feasible in high volume surgical centers with comparable short-term results. Organ preserving surgery is a main goal because of quality of life reasons and is performed whenever possible from the tumor extent. Concerning long-term survival major vein resection does not adversely affect outcome. To date, there are no changes in long-term survival attributed to the extended lymph node dissection. However, there is a benefit in locoregional control with fewer local recurrences and extended lymphadenectomy allows better staging for the disease. CONCLUSIONS: Extended PCa surgery is safe and feasible despite the inconclusive results in patient's survival benefit. In the future, appropriately powered randomized trials of standard vs. extended resections may show improved outcomes for PCa patients. | Alexander Koliopanos C Avgerinos Athanasios Farfaras C Manes Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 4 |
| 6 | Effects of glucose-lowering agents on ischemic stroke显示文摘Diabetes mellitus(DM) is a major risk factor for cardiovascular events, including ischemic stroke. Moreover, ischemic stroke appears to be more severe in these patients and to be associated with less favorable outcomes. However, strict glycemic control does not appear to reduce the risk of ischemic stroke. On the other hand, newer glucose-lowering agents(glucagon-like peptide 1 receptor agonists and sodiumglucose cotransporter 2 inhibitors) reduced the risk of cardiovascular events in recent randomized, placebocontrolled trials. Semaglutide also reduced the risk of ischemic stroke. These benefits are independent of glucose lowering and might be due to the favorable effects of these agents on body weight and blood pressure. Pioglitazone also reduced the risk of recurrent stroke in patients with insulin resistance or type 2 DM but the unfavorable safety profile limits its use. In contrast, sulfonylureas and dipeptidyl peptidase 4 inhibitors have a neutral effect on cardiovascular morbidity and might be less attractive options in this high-risk population. | Konstantinos Avgerinos Konstantinos Tziomalos | 2017 | World Journal of Diabetes2017，8，6： | 3 |
| 7 | The chimney graft technique for preserving visceral vessels during endovascular treatment of aortic pathologies显示文摘 | Konstantinos G. Moulakakis Spyridon N. Mylonas Efthimios Avgerinos Anastasios Papapetrou John D. Kakisis Elias N. Brountzos Christos D. Liapis | 2012 | Journal of Vascular Surgery2012，，5： | 2 |
| 8 | 消化性溃疡出血患者使用生长抑素抑制胃酸分泌效果优于潘托拉唑:一项前瞻性、随机、安慰剂对照试验 | Avgerinos A. Sgouros S. Viazis N. 陈云茹 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，9： | 2 |
| 9 | Fifteen‐Year Experience and Outcomes of Pericardiectomy for Constrictive Pericarditis显示文摘 | Dimitrios Avgerinos Yuri Rabitnokov Berhane Worku Siyamek Neragi‐Miandoab Leonard N. Girardi | 2014 | J Card Surg2014，，4： | 2 |
| 10 | Acutelung injury in a rat model of intestinal ischemia-reperfusion:the po-tential time depended role of phospholipases A2显示文摘 | Kostopanagiotou G Avgerinos E Costopanagiotou C | 2008 | J Surg Res2008，147，1： | 1 |
| 11 | somatostatin and octreotide in the management of acute variceal hemorrhage 显示文摘 | Avgerinos A Armonis A Raptis S | 1995 | Hepatagastroenterology1995，42，2： | 1 |
| 12 | Management of endoscopic retrograde cholangio- pancreatography: related duodenal perforations 显示文摘 | Avgerinos D V Llaguna O H Lo A Y Voli J Leitman I M | 2009 | Surg Endosc2009，23，： | 1 |
| 13 | Thermoplastic polymers reinforced with fibrous agricultural residues 显示文摘 | S Th Georgopoulos P A Tarantili E Avgerinos etal | 2005 | Polymer Degradation and Stability2005，90，： | 1 |
| 14 | Protective Effect of NAC Preconditioning Against Ischemia-Reperfusion Injury in Piglet Small Bowel Transplantation: Effects on Plasma TNF, IL-8, Hyaluronic Acid, and NO显示文摘 | Georgia Kostopanagiotou Efthimios D. Avgerinos Efthimia Markidou Panagiotis Voiniadis Constantinos Chondros Kassiani Theodoraki Vassilios Smyrniotis Nikolaos Arkadopoulos | 2011 | Journal of Surgical Research2011，，2： | 1 |
| 15 | Benefits and limitations of enteral nutrition in the early postoperative period显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，： | 1 |
| 16 | Measurement of the resistive leakage current in surge arresters under artifieial rain test and impulse voltage subjection显示文摘 | Christodoulou C A Avgerinos M V Ekonomou L | 2009 | IET Science Measurement and Technology2009，3，3： | 1 |
| 17 | Nutritional support in acute pancreatitis显示文摘 | Avgerinos C Delis Rizos S Dervenis C | | 0，，： | 1 |
| 18 | Somatostatin inhibits gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: a prospective, randomized, placebo - controlled trial 显示文摘 | Avgerinos A Sgouros S Viazis N | 2005 | Stand J Gastroenterol JT Scandinavian journal of gastroenterology2005，40，51： | 1 |
| 19 | Somatostatin inhibits gastri- eaeid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: a prospective, randomized, placebo-controlled trial显示文摘 | Avgerinos A Sgouros S Viazis N | 2005 | Seand J Gastroentero12005，40，5： | 1 |
| 20 | Somatostatin inhibits gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding :a prospective,randomized,placebo-controlled trial显示文摘 | Avgerinos A Sgouros S Viazis N | 2005 | Scand J Gastroenterol2005，40，5： | 1 |
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