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| 1 | Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights显示文摘The gut microbiome plays an important role in the variation of pharmacologic response.This aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing therapy.The impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of research.Pancreatic adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very limited.Newer studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of PAC.This review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC. | Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman | 2023 | World Journal of Gastroenterology2023，29，25： | 2 |
| 2 | Assay of cetazidime in biological fluids using highperformance liquid chromatography 显示文摘 | AYRTON J | 1981 | J Antimicrob Chemother1981，8，： | 1 |
| 3 | Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma显示文摘 | Ayrton J Dear GJ Leavens WJ et al | 1998 | J Chromatogr A1998，828，12： | 1 |
| 4 | Role of transport proteins in drug absorption, distribution and excretion 显示文摘 | Ayrton A Morgan P | 2001 | Xenobiotica2001，31，829： | 1 |
| 5 | Role of transport proteins in drug ab- sorption, distribution and excretion 显示文摘 | AYRTON A MORGAN P | 2001 | Xenobiaticu2001，31，89： | 1 |
| 6 | Influence of citric acid as chemical modifier for lead determination in dietary calcium supplement samples by graphite furnace atomic absorption spectrometry显示文摘 | Julio Cezar Paz de M Adriane M N Ayrton F M | 2005 | Spectrochimica Acta Part B2005，60，5： | 1 |
| 7 | Mechanism of the in vitro antimutagenic action of retinal 显示文摘 | Ioannides C Ayrton AD Keele A | 1990 | Carcinogenesis1990，5，： | 1 |
| 8 | The origin and growth of the ripple mark显示文摘 | Ayrton H | 1910 | Proe Roy Soe of London1910，84，： | 1 |
| 9 | The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma显示文摘 | Dear GJ Leavens WJ | 1997 | Rapid Commun Mass Spectrom1997，11，： | 1 |
| 10 | Role of transport proteins in drug absorption, distribution and excretion 显示文摘 | Ayrton A Morgan P | 2001 | Xenobiotica2001，31，89： | 1 |
| 11 | Weight gain over 4 months in schizophrenia patients: acomparion of olanzapine and risperidone 显示文摘 | Ganguli R Brar J S Ayrton Z | 2001 | Schizophr Res2001，49，3： | 1 |
| 12 | Role of transport proteins in drug absorption distribution and excretion显示文摘 | Ayrton A Morgan P | 2001 | Xenobiotica2001，31，89： | 1 |
| 13 | Role of transport proteins in drug absorption,distribution and excretion显示文摘 | AYRTON A MORGAN P | 2001 | Xenobiotica2001，31，89： | 1 |
| 14 | Role of transport proteins in drugab sorption, distribution and excretion 显示文摘 | Ayrton A Morgan P | 2001 | Xenobiotica2001，31，89： | 1 |
| 15 | Cytochrome P4501A(CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan显示文摘 | Beresford AP Ellis WJ Ayrton J | 1997 | Xenobiotica1997，27，2： | 1 |
| 16 | 'The Mechanism of the Electric Arc' 显示文摘 | Ayrton H | 1902 | Proceedings of the Royal Society of London Series A1902，199，： | 1 |
| 17 | Treatment of a Trifluraline Effluent by Means of Oxidation - coagulation with Fe(VI) and Combined Fenton Processes显示文摘 | Ayrton F Martins Carla da S Frank Marcelo L Wilde | 2007 | Clean2007，35，1： | 1 |
| 18 | Antimutagenicity of ellagic acid towardsthe food mutagen IQ : investigation intopossible mechanisms of action 显示文摘 | Ayrton A D Lewis D F Walker R | 1992 | FoodChem Toxic1992，4，30： | 1 |
| 19 | 'On the Non-Periodic or Residual Motion of Water Moving in Stationary Waves' 显示文摘 | Ayrton H | 1908 | Proceedings of the Royal Society of London Series A1908，80，538： | 1 |
| 20 | Anthill earth as a gold occurrence indicator,and gold determination by solid sampling flame atomic absorption spectrometry显示文摘 | José Neri G Paniz (E)rico Marion de M Flores Ayrton F Martins | 2005 | Microchimica Acta2005，152，12： | 1 |
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