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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | The multidimensional fatigue inventory(MFI) psychometric qualities of an instrument to assess fatigue显示文摘 | Smets E M Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 3 | Anesthesiology:a survey of anaesthesiological practice显示文摘 | Mcennan N Bonk B Oosting J | 1993 | Anesthesiology1993，79，3： | 1 |
| 4 | Postoperative cognitive dysfunction in the elderly显示文摘 | Bonke B | 1998 | Lancet1998，351，9119： | 1 |
| 5 | Assessment of preope-rative anxiety:comparison of measures in patients awaiting surgery for breast cancer显示文摘 | Millar K Jelicic M Bonke B | 1995 | Br J Anaesth1995，74，2： | 1 |
| 6 | Assessment of preoperative anxiety : comparison of measures in patients awaiting surgery for breast cancer显示文摘 | Millar K Jelieic M Bonke B | 1995 | Br J Anaesth1995，74，2： | 1 |
| 7 | The Multidimensional Fatigue Inventory ( MFI ) psychometric qualities of an instrument to assess fatigue 显示文摘 | Smets E M Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 8 | The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue 显示文摘 | SMETS E M GARSSEN B BONKE B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 9 | The Multidimensional Fa- tigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue显示文摘 | Smets EM Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 10 | The multidimen-sional fatigue scale: psychometric qualities of an instrument toassess fatigue显示文摘 | SMETS EMA GARSSEN B BONKE B^etal | 1995 | J Psycho Res1995，39，： | 1 |
| 11 | Awareness:monitoring versus remembering what happened显示文摘 | Kerssens C Klein J Bonke B | 2003 | Anesthesiology2003，99，： | 1 |
| 12 | Production of alpha-1, 3-galactosyltransferase knockout pigs by nuclear transfer cloning显示文摘 | Lai L Kolber-Simonds D Park K W Cheong H T Greenstein J L Im G S Samuel M Bonk A Rieke A DayB N Murphy C N Carter D B Hawley R J Prather R S | 2002 | Science2002，295，5557： | 1 |
| 13 | The Multidimensional Fatigue Inventory(MFI)psychometric qualities of an instrument to assess fatigue显示文摘 | Smets EM Garssen B Bonke B | | 0，，： | 1 |
| 14 | The multidimensional fa- tigue inventory(MFI) psychometric qualities o{ an instrument to assess fatigue显示文摘 | Smets EM Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 15 | Assessment of preoperative anxiety: comparison of measures in patients awating surgery for breast cancer 显示文摘 | MILLAR K JELICIE M BONKE B | 1995 | Br J Anaesth1995，74，： | 1 |
| 16 | The Multidi- mensional Fatigue Inventory(MFI) psychometric qualities of an instrument to assess fatigue 显示文摘 | SMETS EM GARSSEN B BONKE B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 17 | Assessment of preoperative anxiety:comparison of measures in patients awating surgery for breast cancer显示文摘 | Jelicie M Bonke B etal | 1995 | Br J Anaestn1995，74，： | 1 |
| 18 | The Multidimensional Fatigue Inventory ( MFI ) psychometric qualities of an instrument to assess fatigue显示文摘 | Smets Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
| 19 | The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue 显示文摘 | Smets EM Garssen B Bonke B | 1995 | Journal of psychosomatic research1995，39，3： | 1 |
| 20 | The multidimensional fa- tigue inventory(MFI) psycho metric qualities of an instrument to assess fatigue 显示文摘 | Smets EM Garssen B Bonke B | 1995 | J Psychosom Res1995，39，3： | 1 |
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