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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)显示文摘 | Nuh N. Rahbari O. James Garden Robert Padbury Mark Brooke-Smith Michael Crawford Rene Adam Moritz Koch Masatoshi Makuuchi Ronald P. Dematteo Christopher Christophi Simon Banting Val Usatoff Masato Nagino Guy Maddern Thomas J. Hugh Jean-Nicolas Vauthey Pau | 2011 | Surgery2011，，5： | 4 |
| 3 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 4 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H. Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T. Kaifi Martina Mirlacher Tim H. Brümmendorf Carsten Bokemeyer Jakob R. Izbicki Guido Sauter | 2009 | Human Pathology2009，，6： | 3 |
| 5 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)显示文摘 | Nuh N. Rahbari O. James Garden Robert Padbury Mark Brooke-Smith Michael Crawford Rene Adam Moritz Koch Masatoshi Makuuchi Ronald P. Dematteo Christopher Christophi Simon Banting Val Usatoff Masato Nagino Guy Maddern Thomas J. Hugh Jean-Nicolas Vauthey Pau | 2011 | Surgery2011，，5： | 2 |
| 6 | The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study显示文摘 | Ombretta Salvucci Amélie Bouchard Andrea Baccarelli Jean Deschenes Guido Sauter Ronald Simon Rosella Bianchi Mark Basik | 2006 | Breast Cancer Research and Treatment2006，，3： | 2 |
| 7 | Effect of weekend admission on geriatric hip fractures显示文摘BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well documented.With respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care hospital.It was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a weekday.AIM To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical delay.METHODS A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was conducted.Two cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a weekday.Primary outcome measures included mortality rate,complication rate,transfusion rate,and length of stay.Secondary outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to surgery.RESULTS There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday cohorts.Complication rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients who presented to the hospital on a weekday.CONCLUSION This study provided insight into the“weekend effect”for geriatric hip fractures and found that day of presentation has a clinically significant impact on delivered care. | Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph Chang Ronald J Simon Kevin K Kang | 2020 | World Journal of Orthopedics2020，11，9： | 2 |
| 8 | Mechanisms Underlying Selective Neuronal Tracking of Attended Speech at a “Cocktail Party”显示文摘 | Elana M. Zion Golumbic Nai Ding Stephan Bickel Peter Lakatos Catherine A. Schevon Guy M. McKhann Robert R. Goodman Ronald Emerson Ashesh D. Mehta Jonathan Z. Simon David Poeppel Charles E. Schroeder | 2013 | Neuron2013，，5： | 1 |
| 9 | Control of vascular cell pro- liferation and migration by PPAR-:/显示文摘 | Willa H Simon J Ronald EL | 2001 | Diabetes Care2001，24，2： | 1 |
| 10 | Aspirin-exacerbated respiratory disease:Update on medical management显示文摘Aspirin-exacerbated respiratory disease(AERD)is frequently diagnosed in patients with severe type 2 airway inflammation presenting with nasal polyps and severe asthma.It has been associated with a recalcitrant course with high medical and surgical requirements.The advent of recent biological and other targeted treatments show promise in the medical management of patient with AERD.The goal of complete disease control where patients no longer require recurrent surgical procedures,systemic corticosteroid exposure and may live with a stable and relatively normal quality of life is now within reach.Further work is necessary to identify biomarkers predictive of treatment response. | Andrew A.White Katharine Woessner Ronald Simon | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 1 |
| 11 | Diverse expression patterns of the EMT suppressor grainyhead‐like 2 ( GRHL 2) in normal and tumour tissues显示文摘 | Sabine Riethdorf Sabrina Frey Sonja Santjer Malgorzata Stoupiec Benjamin Otto Lutz Riethdorf Christina Koop Waldemar Wilczak Ronald Simon Guido Sauter Klaus Pantel Volker Assmann | 2016 | Int. J. Cancer2016，，： | 1 |
| 12 | George, Coal as a Source Rock for Oil : A review 显示文摘 | Ronald W T Wilkins Simon C | 2000 | International Journal of Coal Geology2000，50，14： | 1 |
| 13 | Recent Advances in Augmented Reality 显示文摘 | Ronald Azuma Yohan Baillot Reinhold Behringer Steven Feiner Simon Julier Blair MacIntyre | 2001 | IEEE Computer Graphics and Applications2001，，1112： | 1 |
| 14 | Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group显示文摘 | Robert H. Squires Benjamin L. Shneider John Bucuvalas Estella Alonso Ronald J. Sokol Michael R. Narkewicz Anil Dhawan Philip Rosenthal Norberto Rodriguez-Baez Karen F. Murray Simon Horslen Martin G. Martin M. James Lopez Humberto Soriano Brendan M. McGuir | 2006 | The Journal of Pediatrics2006，，5： | 1 |
| 15 | The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study显示文摘 | Ombretta Salvucci Amélie Bouchard Andrea Baccarelli Jean Deschenes Guido Sauter Ronald Simon Rosella Bianchi Mark Basik | 2006 | Breast Cancer Research and Treatment2006，，3： | 1 |
| 16 | CD8 + T cells characterize early smoking-related airway pathology in patients with asthma显示文摘 | A. Janneke Ravensberg Annelies M. Slats Sandra van Wetering Kirsten Janssen Simone van Wijngaarden Ronald de Jeu Klaus F. Rabe Peter J. Sterk Pieter S. Hiemstra | 2013 | Respiratory Medicine2013，，7： | 1 |
| 17 | A biliary HCO3? umbrella constitutes a protective mechanism against bile acid‐induced injury in human cholangiocytes显示文摘 | Simon Hohenester Lucas Maillette de Buy Wenniger Coen C. Paulusma Sandra J. van Vliet Douglas M. Jefferson Ronald P. Oude Elferink Ulrich Beuers | 2011 | Hepatology2011，，1： | 1 |
| 18 | Job demands, social support, work satisfaction and psychological well-being among nurses in Spain显示文摘 | Ronald JB Scott M Simon D | 2012 | ESADE Business School Research Paper Series2012，，： | 1 |
| 19 | Clinical Practice Guideline: Endpoints of Resuscitation显示文摘 | Samuel A. Tisherman Philip Barie Faran Bokhari John Bonadies Brian Daley Lawrence Diebel Soumitra R. Eachempati Stanley Kurek Fred Luchette Juan Carlos Puyana Martin Schreiber Ronald Simon | 2004 | The Journal of Trauma: Injury, Infection, and Critical Care2004，，： | 1 |
| 20 | Recent Advances in Augmented Reality显示文摘 | Yohan Baillot Steven Feiner Simon JUlier Blair MacIntyre | 2001 | Survey2001，2001，： | 1 |
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