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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 质子注入和快速退火对GaAs/AlGaAs量子阱红外探测器的影响显示文摘利用质子注入和快速退火技术改变GaAs/AlGaAs量子阱能级分布,使量子阱红外探测器的光电特性发生变化,在较大地移动了探测波长的同时,探测器的响应率、探测率以及暗电流特性也发生相应变化.在质子注入剂量为2.5×1015cm-2、快速退火条件为950℃、30s时,峰值探测波长移动2μm. | 李娜 陆卫 李宁 刘兴权 袁先漳 窦红飞 沈学础 FU Lan Tan H H C Jagadish M B Johnston M Gal | 2000 | 红外与毫米波学报2000，19，1： | 3 |
| 4 | Hidden semi-Markov model for anomaly detection显示文摘 | Tan X B Xi H S | 2008 | Applied Mathematics and Computation2008，205，2： | 1 |
| 5 | Nitrogen, sulfur, and chlorine trans- formations during the pyrolysis of straw显示文摘 | Wang X B Si J P Tan H Z | 2010 | Energy & Fuels2010，24，9： | 1 |
| 6 | Improving the nutritive value of full-fat rice bran for broiler chickens using a lipase-basedenzyme preparation显示文摘 | Tan S H Thomas D V Cumden B Je t al | 2000 | Asian Australasian Journal of Animal Sciences2000，13，3： | 1 |
| 7 | Short-term outcomes from a multicenter retrospective study in China comparing laparoscopic and open surgery for the treatment of infected pancreatic necrosis显示文摘 | Tan J Tan H Hu B | 2012 | J Laparoendosc Adv Surg Tech A2012，22，1： | 1 |
| 8 | Comparative mapping of QTLs for agronomic traits of rice across environment by using a doubled-haploid population显示文摘 | Lu C F Shen L H Tan Z B | 1997 | Theor Appl Genet1997，94，1： | 1 |
| 9 | Geothermal constraints on enrichment of boron and lithium in sale lakes:An example from a river-salt lake system on the northern slope of the eastern Kunlun Mountains,China显示文摘 | Tan H B Chen J Rao W B | 2012 | Journal of Asian Earth Sciences2012，51，： | 1 |
| 10 | Atomic Layer Deposition of a MoSz Film显示文摘 | Tan L 14 Liu B Teng J H | 2014 | Nanoscale2014，6，10： | 1 |
| 11 | iDistance: an adaptive B-tree based indexing method for nearest neighbor search显示文摘 | JAGADISH H V OOI B C TAN K L | 2005 | ACM Transactions on Da tabase Systems2005，30，2： | 1 |
| 12 | The effects of oral anti - hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes显示文摘 | BUSE J B TAN M H PRINCE M J | 2004 | Diabetes Obes Metab2004，6，2： | 1 |
| 13 | In situ observation of thermo and stress induced martensitic transformation in shape memory alloys显示文摘 | Xu H B Tan S Muller I | 1998 | Metallkunde1998，89，： | 1 |
| 14 | Characterisation of vegetable oils by surface acoustic wave sensing electronic nose显示文摘 | GAN H L CHEMAN Y B TAN C P | 2005 | Food Chemistry2005，89，： | 1 |
| 15 | Experimental tests of different types of bolted steel beam-column joints under a central- column-removal scenario 显示文摘 | Yang B Tan K H | 2013 | Engineering Structures2013，54，： | 1 |
| 16 | Defeating SQL injection显示文摘 | Shar L K Tan H B K | 2013 | IEEE Computer Society2013，46，3： | 1 |
| 17 | A novel nanofil- tration membrane prepared with PAMAM and TMC by in situ interfacial polymerization on PEK-C ultrafiltra- tion membrane显示文摘 | Li L C Wang B G Tan H M | 2006 | J Membr Sci2006，269，12： | 1 |
| 18 | Catalytic reforming of methane with CO2 over metal foam based monolithic catalysts显示文摘 | SANG L X SUN B TAN H Y | 2012 | International Journal ofHydrogen Energy2012，37，13： | 1 |
| 19 | Application of attenuated total reflectance-fourier transform infrared technique in the monitoring and control of anti-solvent crystallization显示文摘 | Yu Q Z Chou P S Tan R B H | 2006 | Ind Eng Chem Res2006，45，1： | 1 |
| 20 | Coadministration of chicken GM-CSF with a DNA vaccine expressing Infectious bronchitisvirus(IBV)S1 glycoprotein enhances the specific immune response and protects against IBVinfection显示文摘 | Tan B Wang H Shang L | 2009 | Arch Virol2009，154，7： | 1 |
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