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| 1 | Intestinal M cells:The fallible sentinels?显示文摘The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense against mucosal microbial pathogens and it plays a crucial role in maintaining mucosal homeostasis. Membranous or microfold cells, commonly referred to as microfold cells, are specialized epithelial cells of the gut-associated lymphoid tissues (GALT) and they play a sentinel role for the intestinal immune system by delivering luminal antigens through the follicle-associated epithelium to the underlying immune cells. M cells sample and uptake antigens at their apical membrane, encase them in vesicles to transport them to the basolateral membrane of M cells, and from there deliver antigens to the nearby lymphocytes. On the flip side, some intestinal pathogens exploit M cells as their portal of entry to invade the host and cause infections. In this article, we briefly review our current knowledge on the morphology, development, and function of M cells, with an emphasis on their dual role in the pathogenesis of gut infection and in the development of host mucosal immunity. | Harvey Miller Rhonda KuoLee Girishchandra B Patel | 2007 | World Journal of Gastroenterology2007，13，10： | 6 |
| 2 | Stress -restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus 显示文摘 | Harvey B H Oosthuizen F Brand L | 2004 | Psychopharmacology ( Berl )2004，175，4： | 1 |
| 3 | Ethanol and mitotic inhibi tors promote differentiation of trophoblastic cells 显示文摘 | Harvey B Fisher SE | 1996 | Alcohol Clin Exp Res1996，20，7： | 1 |
| 4 | Oxidative stress in submerged cultures of fungi显示文摘 | Bai Z H Harvey L M and McNeil B | 2003 | Critical Reviews in Biotechnology2003，24，4： | 1 |
| 5 | Synaptophysin immunocytochemistry with thermal intensification:a marker of terminal axonal maturation in the human fetal n-ervous system显示文摘 | Harvey B Donald E | 1999 | Brain & Development1999，21，1： | 1 |
| 6 | Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors显示文摘 | Donehower L A Harvey M Slagle B M | 1992 | Nature1992，356，： | 1 |
| 7 | Improvement of diosgenin yield from Dioscorea deltoidea plant cell cultures by use of a non-traditional hydrolysis method显示文摘 | Denis D Yves S Harvey W B | 1986 | Planta Medica1986，，6： | 1 |
| 8 | Effect of motor vehicle emissions on respiratory health in an urban area显示文摘 | BUCKER DGE D GLAZIER R HARVEY B | 2002 | Environmental Health Perspective2002，110，： | 1 |
| 9 | Renal replacement therapy for a- cute renal failure in children:European guidelines显示文摘 | Strazdins V Watson AR Harvey B | 2004 | Pediatr Neph- rol2004，19，2： | 1 |
| 10 | Effect of aeration rate and waste load on evolution of volatile fatty acids and waste stabilization during thermophilic aerobic digestion of a model high strength agricultural waste 显示文摘 | Obeta U J Harvey L M McNeil B | 2005 | Biore- sour Techno12005，96，5： | 1 |
| 11 | Intrastratal solution and non-opaque heavy mineralsin shales显示文摘 | Harvey B | 1969 | Journal of Sedimentary Research1969，39，2： | 1 |
| 12 | Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux : Bristol helicobacter project 显示文摘 | Harvey RF Lane JA Murray B | 2004 | BMJ2004，328，7453： | 1 |
| 13 | Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats:a comparison with lentiviral vectors显示文摘 | Harvey AR Kamphuis W Eggers R Symons NA Blits B Niclou S et ol | 2002 | Mol Cell Neurosci2002，21，1： | 1 |
| 14 | The genus Gluconobacter and its applications in biotechnology显示文摘 | MACAULEY S MCNEIL B HARVEY L M | | 0，，01： | 1 |
| 15 | FPLD implementation of a PN-matched filter correlator显示文摘 | HARVEY B A BOUEY C | 2003 | Proceedings of IEEE Southeastcon2003，，46： | 1 |
| 16 | The relative importance of manganese and iron oxides and organic matter in the sorption of trace metals by surficial lake sediments显示文摘 | Young L B Harvey H H | 1992 | Geochimica et Cosmochimica Acta1992，56，： | 1 |
| 17 | In vitro inhibi- tion of Salmonella enterica serovars choleraesuis and typhimurium, Escherichia coli F-18, and Escherichia coli O157:H7 by a porcine continuous-flow competitive exclusion culture显示文摘 | HARVEY R B DROLESKEY R E HUME M E | 2002 | Curr Microbiol2002，45，3： | 1 |
| 18 | Sensitivity of strategic highway research program A-003A testing equipment to mix design parameters for permanent deformation and fa-tigue显示文摘 | SOUSA J B TAYEBALI A HARVEY J | 1993 | Journal of the Transportation Research Board1993，1384，： | 1 |
| 19 | Hydrat- ed sodium calcium aluminosilicate: a high affinity sor- bent for aflatoxin 显示文摘 | Phillips T D Kubena L F Harvey R B | 1988 | Poultry Science1988，67，2： | 1 |
| 20 | Analysis of risk factors for local delivery of low-and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid condition 显示文摘 | Crystal R G Harvey B Wisnivesky J P | 2002 | Hum Gene Ther2002，，13： | 1 |
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