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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Stress -restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus 显示文摘 | Harvey B H Oosthuizen F Brand L | 2004 | Psychopharmacology ( Berl )2004，175，4： | 1 |
| 3 | Induction chemotherapy with paclitaxel,cisplatin and 5-Xuorouracil for squamous cell carcinoma of the head and neck:long-term results of a phase II trial显示文摘 | Hitt R Paz-Ares L Brandáriz A | 2003 | Ann Oncol2003，13，： | 1 |
| 4 | A dynamic wind farm aggregate model for the simulation of power fluctuations due to wind turbulence显示文摘 | Tommasi L D Gibescu M Brand A J | 2010 | Journal of Computational Science2010，1，2： | 1 |
| 5 | An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited by type Ⅱ collagen显示文摘 | Brand D Myers L | 1997 | J Exp Med1997，185，6： | 1 |
| 6 | Assessing urban impacts on water quality benthic communities and fish in streams of the mountains, Patagonia (Argentina)显示文摘 | Miserendino M L Brand C Y Prmzio D | 2008 | Water Air Soil and Pollutes2008，，194： | 1 |
| 7 | Two Dimension Photoic- Bandgap Structure Operating at Near Infrared Wavelengths显示文摘 | Krauss T F Rue D L RM Brand S | 1996 | Nature1996，383，： | 1 |
| 8 | Black death,a disease syendrome of penaeid shrimp related to a dietary deficiency of ascorbic acid显示文摘 | LIGHTNER D V COLVIN L B BRAND C | 1977 | Proceedings of the Annual Meeting:World Mariculture Society1977，8，1234： | 1 |
| 9 | Induction of autoimmune arthritis in HLA-DR4 (DRB1 * 0401) transgenic mice by immunization with human and bovine type Ⅱ collagen显示文摘 | Brand D Myers L | 1998 | J Immunol1998，95，7： | 1 |
| 10 | Resonance energy transfer: Methods and applications 显示文摘 | WU P BRAND L | 1994 | Anal Biochem1994，218，： | 1 |
| 11 | Transdermal absorption of the herbicide 2,4-dichlorophe-noxyacetic acid is enhanced by both ethanol consumption and sunscreen application 显示文摘 | BRAND R M MCMAHON L JENDRZEJEWSKI J L | 2007 | Food Chem Toxicol2007，45，1： | 1 |
| 12 | Distribution and potential sources and sinks of copper chelators in the Sargasso sea显示文摘 | MOFETT J W ZIKA R G BRAND L E | 1990 | Deep-sea research1990，37，1： | 1 |
| 13 | Response of passerine birds to forest edge in coast redwood forest fragments显示文摘 | Brand L A George T L | 2001 | The Auk2001，118，3： | 1 |
| 14 | Crosspresenting human gamma delta T cells induce robust CD8+alpha beta T cell responses显示文摘 | Brandes M Willimann K Bioley G Lévy N Eberl M Luo M TampéR Lévy F Romero P Moser B | 2009 | Proc Natl Acad Sci USA2009，106，7： | 1 |
| 15 | Intra-ab- dominal pressure measurement during ultrasound assessment of women with stress urinary incontinence: a novel model 显示文摘 | Brand F T Lorenzato F R Nobrega L V | 2006 | Acta Cir Bras2006，21，3： | 1 |
| 16 | Long-term increase in Karenia brevis abun- dance along the southwest Florida coast显示文摘 | Brand L E Compton A | 2007 | Harmful Algae2007，6，： | 1 |
| 17 | Effects of left ventricular hypertrophy on force and Ca2+ handling in isolated rat myocardium显示文摘 | Maier L S Brandes R Pieske B | 1998 | Am J Physiol1998，274，： | 1 |
| 18 | Adequacy of antitetanus prophylaxis in six hospital emergency rooms显示文摘 | Brand D A Acampora D Gottlieb L D | 1983 | New England Journal of Medicine1983，309，11： | 1 |
| 19 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 20 | Maintenance of baseline angiotensin II potentiates insulin hypertension in rats显示文摘 | Brands M W Smith M J Jr | 1998 | Hypertension1998，31，2： | 1 |
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