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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 4 | 脑卒中血栓切除术后血压与短期和长期功能转归的相关性显示文摘缺血性脑卒中机械性血栓切除术后的转归可能受血压的影响。该研究旨在评估全身麻醉期间和清醒镇静期间血压变化与机械性血栓切除术后功能性转归的关系。血管内治疗脑卒中的镇静与气管插管研究是一项涉及血压目标值的,比较在全身麻醉与在清醒镇静的条件下行机械血栓切除疗效的单中心随机试验。 | 刘青 叶鹏 Schnenberger S Uhlmann L Ungerer M Pfaff J Nagel S Klose C Bendszus M Wick W Ringleb PA Kieser M Mhlenbruch MA Bsel J | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 5 | Interleukin-6 gene knockout influences energy balance regulating peptides in the hypothalamic paraventriculaR and supraoptic nuclei显示文摘 | Benrick A Schéle E Pinnock S B | 2009 | J Neuroendocrinol2009，21，7： | 1 |
| 6 | REDIA-impacts of DRG introduction in the acute sector on medical rehabih'tation显示文摘 | von Eif W Sch ii ring S Greitemann B | 2011 | Die Rehabilitation2011，50，4： | 1 |
| 7 | Estimating the support of a high-dimensional distribution显示文摘 | Platt J C Shawe-Taylor J | 2001 | Neural Computation2001，13，7： | 1 |
| 8 | The Idea of the hybrid text intranslation:contact as conflict显示文摘 | SCH FFNER C ADAB B | 2001 | Across Languages and Cultures2001，，16： | 1 |
| 9 | Non-linear component analysis as a kernel eigenvalue problem显示文摘 | Sch¨olkopf B Smola A M¨uller K | | 0，，： | 1 |
| 10 | Nonlinear component analysis is as a kernel eigenvalue problem显示文摘 | SCH(O)LOKOPF B SMOLA A MULLER K | | 0，，05： | 1 |
| 11 | Transplantation of progenitor cells and regeneration enchancement in acute myocardial infarction: final one year results of the TOP-CARE-AMI trial显示文摘 | Sch?chinger V Assmus B Britten MB | 2004 | J Am Coll Cardiol2004，44，8： | 1 |
| 12 | Microcirculation and excretory function of the liver under conditions of carbon dioxide pneumoperitoneum显示文摘 | Leister l Schüler P Vollmar B | 2004 | Surg Endosc2004，18，9： | 1 |
| 13 | New support vector algorithms显示文摘 | Smola A J Williamson B C | 2000 | Neural Computation2000，12，5： | 1 |
| 14 | Use of Saccharomyces cerevisiae cells immobilized on orange peel as biocatalyst for alcoholic fermentation显示文摘 | Sch B S Coleraine B T | 2007 | Bioresource Technology2007，98，4： | 1 |
| 15 | Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation显示文摘 | Al-Sady B Ni W Kircher S Sch?fer E Quail P H | 2006 | Molecular cell2006，23，3： | 1 |
| 16 | A chromatin-modifying function of JNK during stem cell differentiation显示文摘 | Tiwari V K Stadler M B Wirbelauer C Paro R Schübeler D Beisel C | | 0，，： | 1 |
| 17 | Nonlinear component analysis as a kernel eigenvalue problem显示文摘 | Sch(o)lkopf B Smola A Müller K-R | | 0，，05： | 1 |
| 18 | Geochemical evaluation of differentgroundwater-host rock systems for radioactive waste disposal显示文摘 | Metz V Kienzler B Schü?ler W | 2003 | Journalof Contaminant Hydrology2003，61，： | 1 |
| 19 | HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA显示文摘 | Fritsche P Seidler B Schüler S | 2009 | Gut2009，58，10： | 1 |
| 20 | Renewable energy powered membrane technology:salt and inorganic contaminant removal by nanofiltration/reverse osmosis显示文摘 | Richards L A Richards B S Sch(a)fer A I | | 0，，1： | 1 |
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