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| 1 | Advances in hepatocellular carcinoma: Nonalcoholic steatohepatitis-related hepatocellular carcinoma显示文摘An increase in the prevalence of obesity and diabetes mellitus has been associated with the rise in non-alcoholic fatty liver disease(NAFLD). Two-thirds of the obese and diabetic populations are estimated to develop NAFLD. Currently, NAFLD is the most common etiology for chronic liver disease globally. The clinical spectrum of NAFLD ranges from simple steatosis, an accumulation of fat greater than 5% of liver weight, to nonalcoholic steatohepatitis(NASH), a more aggressive form with necroinflammation and fibrosis. Among the patients who develop NASH, up to 20% may advance to cirrhosis and are at risk for complications of end-stage liver disease. One of the major complications observed in patients with NASH-related cirrhosis is hepatocellular carcinoma(HCC), which has emerged as the sixth most common cancer and second leading etiology of cancer-related deaths worldwide. The incidence of HCC in the United States alone has tripled over the last three decades. In addition, emerging data are suggesting that a small proportion of patients with NAFLD may be at higher risk for HCC in the absence of cirrhosis - implicating obesity and diabetes mellitus as potential risk factors for HCC. | Fauzia Z Khan Ryan B Perumpail Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，18： | 10 |
| 2 | Pathogenesis of hepatocarcinogenesis in non-cirrhotic nonalcoholic fatty liver disease:Potential mechanistic pathways显示文摘Although hepatocellular carcinoma(HCC) primarily arises in the background of liver cirrhosis,the development of HCC in nonalcoholic fatty liver disease(NAFLD) without cirrhosis is increasingly recognized. The pathogenesis of NAFLD associated non-cirrhotic HCC is distinct from that of cirrhotic HCC because the metabolic syndrome(MS) along with obesity and insulin resistance(IR) underlie several unique mechanisms that promote tumorigenesis. IR associated with MS,NAFLD,and type 2 diabetes mellitus lead to the release of multiple pro-inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6,leptin and resistin,as well as decreased amounts of adiponectin. These processes favor the development of hepatic steatosis and inflammation within the liver,which precede HCC development. Nevertheless,further investigation is necessary to elucidate the determinants for development of HCC in patients with NAFLD in the absence of cirrhosis. | Ryan B Perumpail Andy Liu Robert J Wong Aijaz Ahmed Stephen A Harrison | 2015 | World Journal of Hepatology2015，7，22： | 6 |
| 3 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 4 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 5 | Advances in alcoholic liver disease:An update on alcoholic hepatitis显示文摘Alcoholic hepatitis is a pro-inflammatory chronic liver disease that is associated with high short-term morbidity and mortality(25%-35% in one month) in the setting of chronic alcohol use. Histopathology is notable for micro- and macrovesicular steatosis, acute inflammation with neutrophil infiltration, hepatocellular necrosis, perivenular and perisinusoidal fibrosis, and Mallory hyaline bodies found in ballooned hepatocytes. Other findings include the characteristic eosinophilic fibrillar material(Mallory's hyaline bodies) found in ballooned hepatocytes. The presence of focal intense lobular infiltration of neutrophils is what typically distinguishes alcoholic hepatitis from other forms of hepatitis, in which the inflammatory infiltrate is primarily composed of mononuclear cells. Management consists of a multidisciplinary approach including alcohol cessation, fluid and electrolyte correction, treatment of alcohol withdrawal, and pharmacological therapy based on the severity of the disease. Pharmacological treatment for severe alcoholic hepatitis, as defined by Maddrey's discriminant factor ≥ 32, consists of either prednisolone or pentoxifylline for a period of four weeks. The body of evidence for corticosteroids has been greater than pentoxifylline, although there are higher risks of complications. Recently head-to-head trials between corticosteroids and pentoxifylline have been performed, which again suggests that corticosteroids should strongly be considered over pentoxifylline. | Randy Liang Andy Liu Ryan B Perumpail Robert J Wong Aijaz Ahmed | 2015 | World Journal of Gastroenterology2015，21，42： | 5 |
| 6 | 北京市城乡40岁以上限定人群视网膜血管异常的患病率显示文摘目的描述北京市城乡限定人群视网膜血管异常(RMA)患病率及其分布特征。设计横断面研究。研究对象'北京眼病研究'城乡40岁以上居民4439人。方法对每位受检者进行问卷调查和全面眼科检查,其中包括散瞳后彩色眼底照相检查。随机选每位受检者一眼进行眼底照片中视网膜血管异常的评价。局限性视网膜血管异常(局限性视网膜动脉缩窄、动静脉交叉压迫征和视网膜病变)采用定性方法评价;弥漫性视网膜动脉缩窄采用计算机辅助的定量方法评价。计算以上各种视网膜血管异常的患病率,并分析其分布特征。主要指标视网膜血管异常的患病率。结果局限性视网膜动脉缩窄、动静脉交叉压迫征和视网膜病变的患病率分别为7.5%、7.2%和7.5%,三者均随年龄的增加而逐渐增加(P<0.001);男性的视网膜血管异常患病率(24.4%)明显比女性(17.6%)高(P<0.001)。各种局限性视网膜血管异常和弥漫性视网膜动脉缩窄的患病率在农村人群均明显高于城市人群(P均<0.001)。结论北京市限定地区城乡40岁以上人群中视网膜血管异常并不少见,其患病率随年龄增加逐渐增加;农村居民比城市居民患病率高。 | 王爽 徐亮 Jonas Jost B Wong Tien Y 王云松 王亚星 杨桦 李静 Sun Cong | 2010 | 眼科2010，19，4： | 4 |
| 7 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 8 | Advances in cirrhosis: Optimizing the management of hepatic encephalopathy显示文摘Hepatic encephalopathy(HE) is a major complication of cirrhosis resulting in significant socioeconomic burden, morbidity, and mortality. HE can be further subdivided into covert HE(CHE) and overt HE(OHE). CHE is a subclinical, less severe manifestation of HE and requires psychometric testing for diagnosis. Due to the time consuming screening process and lack of standardized diagnostic criteria, CHE is frequently underdiagnosed despite its recognized role as a precursor to OHE. Screening for CHE with the availability of the Stroop test has provided a pragmatic method to promptly diagnose CHE. Management of acute OHE involves institution of lactulose, the preferred first-line therapy. In addition, prompt recognition and treatment of precipitating factors is critical as it may result in complete resolution of acute episodes of OHE. Treatment goals include improvement of daily functioning, evaluation for liver transplantation, and prevention of OHE recurrence. For secondary prophylaxis, intolerance to indefinite lactulose therapy may lead to non-adherence and has been identified as a precipitating factor for recurrent OHE. Rifaximin is an effective add-on therapy to lactulose for treatment and prevention of recurrent OHE. Recent studies have demonstrated comparable efficacy of probiotic therapy to lactulose use in both primary prophylaxis and secondary prophylaxis. | Andy Liu Ryan B Perumpail Radhika Kumari Zobair M Younossi Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 9 | Facial trauma and ocular/orbital injury显示文摘 | Larian B Wong B Crumley R L | 1999 | J Craniomaxillofac Trauma1999，5，4： | 2 |
| 10 | A regulatory role for TRAF1 in antigen-induced apoptosis of T cells 显示文摘 | Speiser DE Lee SY Wong B | 1997 | J Exp Med1997，185，10： | 2 |
| 11 | Implications of using two low-power continuous-wave lasers for polishing显示文摘Laser polishing is widely employed to reduce the surface roughness of products with complex geometries.Traditional laser polishing techniques use a single high-power Gaussian beam to melt and smooth a thin layer of surface material.However,the reliance on high power lasers can present practical challenges such as minimizing surface evaporation or reducing overall cost.In this work,we combined two identical low-power laser beams with a spatial offset in between them to construct an elliptical beam.By changing the spatial offset,combined beams with different lengths along the major axis can be created.We observe over 20%improvement in line roughness reduction using this approach compared to a single Gaussian laser beam with the same total power.Additionally,both experiment and simulation results suggest such improvement is because this dual-laser set-up can create a longer molten pool compared to a single laser. | Wenxuan Zhang Kiwan Wong Miguel Morales Carlos Molpeceres Craig B Arnold | 2020 | International Journal of Extreme Manufacturing2020，2，3： | 2 |
| 12 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 13 | Capacitated arc routing problems显示文摘 | Golden B L Wong R T | 1981 | Networks1981，11，： | 1 |
| 14 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 15 | A transmitting boundary for transient wave analysis显示文摘 | Wong H L Yang B P | 1984 | Science Sinica Series A1984，27，： | 1 |
| 16 | 显示文摘 | Zhang Z Handa Y P | 1998 | J Polym Sci Part B: Polym Phys1998，36，12： | 1 |
| 17 | Apixaban,an oral,direct and highly selective factor Xa inhibitoc in vitro,antithrombotic and antihemostatic studies显示文摘 | Wong PC Crain EJ Xin B | 2008 | J Thromb Haemosy2008，6，5： | 1 |
| 18 | Hydrothermal synthesis of perovskite nanotubes显示文摘 | MAO Y B BANERJEE S WONG S S | 2003 | Chem Commun2003，3，： | 1 |
| 19 | Interaction of hyperventilation and a- rousal in the pathogenesis of idiopathic central sleep apneas显示文摘 | Xie A Wong B Phillipson EA | 1994 | Am J Respir Crit Care Med1994，150，： | 1 |
| 20 | Unique immunogenicity of hepatitis B virus DNA vaccine presented by live-attenuated Salmonella typhimurium显示文摘 | Woo P C Wong L P Zheng B J | 2001 | Vaccine2001，19，： | 1 |
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