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| 1 | 根治性手术与短程放疗后行经肛门内镜显微手术(TEM)保留器官治疗早期直肠癌(TREC):一项随机、开放标签的可行性研究显示文摘背景:基于全直肠系膜切除(total mesorectal excision,TME)的根治性手术可能不是早期直肠癌的最佳一线治疗。选择性TME保留器官的策略可以减少治疗的不良反应,又不会显著影响肿瘤结果。该临床随机研究通过与TME比较,探讨器官保留策略的可行性。方法:TREC是一项在英国21个三级转诊中心进行的随机、开放标签的可行性研究。符合条件的受试者年龄≥18岁,分期为T2期或更早,最大直径不超过30 mm;排除淋巴结受累或转移的患者。患者按计算机随机分配(1:1)接受短程放疗保留器官,8~10周后行经肛门内镜显微手术(transanal endo⁃scopic microsurgery,TEM)或TME术。当TEM标本组织病理学特征提示局部复发风险增加时,患者被考虑计划早期转为TME。一项非随机前瞻性登记收集了认为不适合随机化的患者,因为每例患者都是按临床指征治疗的。主要终点为12、18和24个月的累积随机分组。次要结局为应用欧洲癌症研究与治疗组织(EORTC)QLQ C30和CR29量表对意向治疗人群的安全性、有效性和健康相关生活质量进行了评价。该研究已在ISRCTN注册中心注册,ISRCTN14422743。 | 佟伟华 BACH S P GILBERT A BROCK K | 2021 | 结直肠肛门外科2021，27，3： | 9 |
| 2 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 3 | The Yersinia high- pathogenicity island is present in different members of the family Enterobacteriaceae显示文摘 | Bach S de Almeide A Carniel E | 2000 | FEMS Microbiol Lett2000，183，2： | 1 |
| 4 | Content-based image and video retrieval显示文摘 | Bach J Fuller C Gupta A | 2005 | Signal Processing2005，85，2： | 1 |
| 5 | Solid-state dye-sensitized mesoporous TiO2 solar cells with high photon-to-electron conversion efficiencies显示文摘 | Bach U Lupo D Comte P Moser J E Weiss(o)rtel F Salbeck J Spreitzer H Gr(a)tzel M | | 0，，： | 1 |
| 6 | Suspicious cervical lymph nodes detected after thyroidectomy for papillary thyroid cancer usually remain stable over years in properly selected patients显示文摘 | Robenshtok E Fish S Bach A | 2012 | J Clin Endocrinol Metab2012，97，8： | 1 |
| 7 | Association between animal,transportation,slaughter house practices,and meat p H in beef显示文摘 | Mach N Bach A Velarde A | 2008 | Meat Sci2008，78，3： | 1 |
| 8 | Endothelial cells and the IGF system显示文摘 | BACH L A | 2015 | J Mol Endocrinol2015，54，1： | 1 |
| 9 | Thulium: YAG laser enu cleation of the prostate: safety and durability during intermedi- ate term follow-up显示文摘 | Bach T Netsch C Haecker A | 2010 | World J Urol2010，28，1： | 1 |
| 10 | The IFN gamma receptor: a paradigm for cytokine receptor signaling 显示文摘 | BACH E A AGUET M SCHREIBER R D | 1997 | Annu Rev Immunol1997，15，： | 1 |
| 11 | Peripherally inserted central venous catheters for autologous blood progenitor cell transplantation in patients with haematological malignancies显示文摘 | Ostendorf T Bach A | 2003 | Support Care Carmer2003，11，12： | 1 |
| 12 | Redefining the stormwater first flush phenomenon 显示文摘 | BACH P M MCCARTHY D T DELETIC A | 2010 | Water Research2010，44，8： | 1 |
| 13 | A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis显示文摘 | Sagona A P Nezis I P Bache K G | | 0，，03： | 1 |
| 14 | Glucose metabolism in lactating cows in response to isoenergetic infusions of propionic acid or duodenal glucose显示文摘 | LEMOSOUET S RIGOUT S BACH A | 2004 | Dairy Sci2004，87，： | 1 |
| 15 | Peripherally inserted cen-teral catheter for autolohous blood progenitor cell transplanta-tion in patients with haematological malignancies显示文摘 | Hartet C Ostendorf T Bach A | 2003 | Support Care Cancer2003，11，12： | 1 |
| 16 | Peripherally in serted central catheter for au tologous blood progen itor cell transp lantation in patients with haematolog ica lmalign ancies显示文摘 | Harter C Ostendorf T Bach A | 2003 | Support Care Cancer2003，11，12： | 1 |
| 17 | The usefulness of dietary medium-chain triglycerides in body weight control:fact or fancy?显示文摘 | Bach AC Ingenbleek Y Frey A | 1996 | J Lipid Res1996，37，4： | 1 |
| 18 | Delayed reverse sural flap for staged reconstruction of the foot and lower leg显示文摘 | KNESER U BACH A D POLYKANDRIOTIS E | 2005 | Plast Reconstr Surg2005，116，7： | 1 |
| 19 | Glucose metabolism in lactating cows in response to isoener- getic infusions of propionic acid or duodenal glucose 显示文摘 | LEMOSQUET S RIGOUT S BACH A | 2004 | Journal of Dairy Science2004，87，6： | 1 |
| 20 | The develop- ment of a novel approach for assessment of the first flush in urban stormwater discharges显示文摘 | BACH P M MCCARTHY D T DELETIC A | 2010 | Water Science and Technol- ogy2010，61，10： | 1 |
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