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| 1 | Crigler-Najjar syndrome in The Netherlands:identification of four novel UGT1A1 alleles,genotype-phenotype correlation,and functional analysis of 10 missense mutants显示文摘 | Sneitz N Bakker CT de Knegt RJ | | 0，，01： | 1 |
| 2 | UGT1A1 * 28 allele and coronary heart disease, the Rotterdam Study显示文摘 | Bosma PJ van der Meer IM Bakker CT | 2003 | Clin Chem2003，49，7： | 1 |
| 3 | AdEasy-based cloning system to generate tropism expanded replicating adenoviruses expressing transgenes late in the viral life cycle显示文摘 | Lie A Ling M Bakker CT Wesseling JG | 2005 | Gene Ther2005，12，17： | 1 |
| 4 | Crigler - Najjar syndrome in the Netherlands : Identification of four novel UGT1 A1 alleles, genotype - phenotype correlation, and functional analysis of 10 missense mutants 显示文摘 | Sneitz N Bakker CT de Knegt RJ | 2009 | Hum Mutat2009，31，1： | 1 |
| 5 | UGT- 1A1*28 allele and coronary heart disease: the Rotterdam Study显示文摘 | BOSMA PJ VANDER MEER IM BAKKER CT | 2003 | Clin Chem2003，49，7： | 1 |
| 6 | Survival of transca- theter mitral valve repair compared with surgical and conser- vative treatment in high-surgical-risk patients显示文摘 | Swaans M J Bakker AL Alipour A ct al | 2014 | JACC Cardi- ovasc Interv2014，7，8： | 1 |
| 7 | Clinical outcomes of patients with duodenal adenocarcinoma and intestinal-type papilla of Vater adenocarcinoma显示文摘BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological similarities.AIM To retrospectively investigate the clinical outcome of patients with DA and it-PVA.METHODS All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the Netherlands.All patients with histopathologically-confirmed DA or it-PVA were eligible for inclusion.Clinical outcome was compared between DA and it-PVA per disease stage.In the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive care.RESULTS In total,155 patients with DA and it-PVA were included.Patients with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative intent.The median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease stage.Seven(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of oligometastases.Local treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,respectively.CONCLUSION Survival of patients with DA and it-PVA is comparable per disease stage.These results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed. | Laura L Meijer Marin Strijker Jacob K de Bakker Jurgen GJ Toennaer Barbara M Zonderhuis Hans J van der Vliet Hanneke Wilmink Joanne Verheij Freek Daams Olivier R Busch Nicole CT van Grieken Marc G Besselink Geert Kazemier | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 1 |
| 8 | Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1 显示文摘 | Bakker CT Deocharan B | 1998 | Am J Hum Genet1998，62，3： | 1 |
| 9 | Selection of tumour specific promoters for adenoviral gene therapy of cholangiocarcinoma显示文摘 | Lie-A-Ling M Bakker CT Deurholt T | 2006 | J Hepatol2006，44，1： | 1 |
| 10 | UGT1A1*28 al ele and coronary heart disease:The Rot erdam Study显示文摘 | Bosma P J van der Meer I M Bakker CT | | 0，，07： | 1 |
| 11 | UGT1A1*28 allele and coronary heart disease: The Rotterdam study 显示文摘 | Bosma PJ van det Meer IM Bakker CT | 2003 | Clin Chem2003，49，10： | 1 |
| 12 | UGTJA1 -* 28 allele and coro- nary heart disease显示文摘 | Bosma PJ Meer IM Bakker CT | 2003 | Rotterdam Study Clin Chem2003，7，49： | 1 |
| 13 | Splice-site mutations:a novel genetic mechanism of Crigler-Najjar syndrome type 1 显示文摘 | Gantla S Bakker CT Deocharan B | 1998 | Am J Hum Genet1998，62，3： | 1 |
| 14 | The role of per- sonal resources in the job demands-resources model 显示文摘 | Xanthopoulou D Bakker AB Demerouti E ct al | 2007 | lnt J Stress Manage2007，14，2： | 1 |
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