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| 1 | Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21^(WAF1) expression and hepatic apoptosis显示文摘AIM To detect the expression of caspase 3gene in primary human hepatocellular carcinoma(HCC)and investigate its relationship to p21WAF1gene expression and HCC apoptosis.METHODS In situ hybridization was employedto determine caspase 3 and p21WAF1expression inHCC.In situ end-labeling was used to detecthepatocytic apoptosis in HCC.RESULTS Twenty-one of 39(53.8%)cases ofHCC were found to express caspase 3transcripts,while 45.2% of HCC failed toexpress caspase 3.Non-cancerous adjacent livertissues showed more positive caspase 3(87.5%,7/8)as compared with HCC(P<0.05).The expression of caspase 3 is correlated withHCC differentiation,72.2%(13/18)ofmoderately to highly differentiated HCC showedcaspase 3 transcripts positive,while only 38.1%of poorly differentiated HCC harbored caspase 3transcripts(P<0.05).No relationship wasfound between caspase 3 expression and tumorsize or grade or metastasis,although 52.5%(5/8)of HCC with metastasis were caspase 3positive and a little higher than that with nometastasis(51.6%,P>0.05).Expression of caspase 3 alone did not affect the apoptosisindex(AI)of HCC.The AI was 7.12%o in caspase3-positive tumors(n=21),while in caspase 3-negative cases(n=18)6.59%0(P>0.05).Expression of caspase 3 clearly segregated withp21WAF1positive tumors as compared withp21WAF1-negative cases(16 of 23,69.6% versus5 of 16,31.3%)with statistical significance(P=0.017).In the cases with positive caspase 3and negative p21WAF1,the Al was found slightlyhigher,but with no statistical significance,thanthat with expression of p21WAF1and caspase 3(7.21‰ vs 6.98‰,P>0.05).CONCLUSION Loss of caspase 3 expressionmay contribute to HCC carcinogenesis,althoughthe expression of caspase 3 does not correlatewell with cell apoptosis in HCC.p21WAF1may bemerely one of the inhibitors which can reducecaspase 3 mediated cell apoptosis in HCCs. | Bao Hua Sun Jun Zhang Bao JǜWang Xi Ping Zhao You Kun Wang Zhi Qun Yu Dong Liang Yang Lian Jie Hao Department of Clinical Immunology,Tongji Hospital,Tongji Medical University,Wuhan 430030,Hubei Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 65 |
| 2 | 茶叶摄入与中国成年人高密度脂蛋白胆固醇浓度纵向变化的关系显示文摘茶叶摄入与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)浓度的年龄相关变化之间的关系仍不清楚。该研究目的是探索茶摄入量与HDL-C浓度纵向变化之间的关系。研究人员通过调查问卷评估基线(2006年)的茶叶消费量,并在2006、2008、2010和2012年测量了未患有心血管病或癌症. | 刘莉 叶鹏 Huang S Li J Wu Y Ranjbar S Xing A Zhao H Wang Y Shearer GC Bao L Lichtenstein AH Wu S Gao X | 2018 | 中华高血压杂志2018，26，8： | 5 |
| 3 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 4 | Impact of charge ordering on magnetic correlations in perovskite (Bi,Ca) MnO3 显示文摘 | BAO W AXE J D CHEN C H | 1997 | Phys Rev Lett1997，78，： | 2 |
| 5 | Engineering imaging probes and molecular machines for nanomedicine显示文摘Nanomedicine is an emerging field that integrates nanotechnology, biomolecular engineering, life sciences and medicine; it is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures and devices with proteins and nucleic acids, the design, synthesis and application of nanoprobes, nanocarriers and nanomachines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection, therapy, and prevention. Recent advances in nanomedicine include the development of functional nanoparticle based molecular imaging probes, nano-structured materials as drug/gene carriers for in vivo delivery, and engineered molecular machines for treating single-gene disorders. This review focuses on the development of molecular imaging probes and engineered nucleases for nanomedicine, including quantum dot bioconjugates, quantum dot-fluorescent protein FRET probes, molecular beacons, magnetic and gold nanoparticle based imaging contrast agents, and the design and validation of zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs) for gene targeting. The challenges in translating nanomedicine approaches to clinical applications are discussed. | TONG Sheng CRADICK Thomas J MA Yan DAI ZhiFei BAO Gang | 2012 | Science China(Life Sciences)2012，55，10： | 2 |
| 6 | Recent progresses in plastic electronics 显示文摘 | Rogers J A Bao Z Balduin K | 2001 | Proceedings of National Academy of Sciences2001，98，： | 2 |
| 7 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 8 | Robust mult-loop PID controller design-a successive semi-definite programming approach显示文摘 | BAO J FORBES J F MCLELLAN P J | 1999 | Ind Eng Chem Process Des Dev1999，38，： | 2 |
| 9 | GSK-3β inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation显示文摘 | Carmichael J Sugars K L Bao Y P | 2002 | J Biol Chem2002，277，33： | 1 |
| 10 | New Air-stable n-Channel Organic Thin Film Transistors 显示文摘 | BAO Zhen-an I_ovinger A Brown J | 1998 | J Am Chem Soc1998，120，1： | 1 |
| 11 | Modified generalized Lorenz system and fold chaotic attractors显示文摘 | Bao B C Liu Z Yu J B | 2009 | International Journal of Bifurcation and Chaos2009，19，8： | 1 |
| 12 | Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover显示文摘 | Street J Bao M deGuzman L | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 13 | Combined distributed temperature and strain sensor based on Brillouin loss in an optical fiber 显示文摘 | BAO X WEBB D J JACKSON D A | 1994 | Opt Lett1994，19，2： | 1 |
| 14 | Traumatic brain injury reduces hippocampal high-afiqnity choline uptake but not extracellular cholines levels in rats 显示文摘 | Dixon C E Bao J Bergmann J S | 1994 | Neurosci Lett1994，180，2： | 1 |
| 15 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 16 | A study of drilling uni-directionalcarbon/epoxy composites显示文摘 | Gao H Bao Y J Feng Z M | 2011 | International Journal of AbrasiveTechnology2011，4，1： | 1 |
| 17 | Time-frequency imaging algorithm for high speed spinning targets in two dis- mensions 显示文摘 | Li J Qiu C W Xing M D Bao Z Yeo T S | 2010 | lET2010，4，6： | 1 |
| 18 | Development of one-step real-time RT-PCR assay for detection and quantitation of peste des petits ruminants virus显示文摘 | Bao J Li L Wang Z | 2008 | J Virol Meth-ods2008，148，12： | 1 |
| 19 | Inducible ni-tric oxide synthase expression inhibition by adenovi-rus E1A显示文摘 | CAO W BAO C LOWENSTEIN C J | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 20 | The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance显示文摘 | Pagel-Langenickel I Bao J Pang L | 2010 | Endocr Rev2010，31，1： | 1 |
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