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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Early domesticated fig in the Jordan Valley显示文摘 | Kislev M E Hartmann A Bar Yosef O | 2006 | Science2006，312，： | 1 |
| 3 | Protective effect of Bax ablation against cell loss in the retinal ganglion layer induced by optic nerve crush in transgenic mice显示文摘 | Goldenberg-Cohen N Dratviman-Storobinsky O Dadon Bar E1 S | 2011 | J Neuroophthalmol2011，31，： | 1 |
| 4 | Comparison of stress distribution between complete denture and implant retained overdenture2D FEA显示文摘 | Assun oWG T abata LF Bar o VA | 2008 | J Oral Rehabi2008，35，10： | 1 |
| 5 | Survey of automatic modulation classification techniques: classical approa- ches and new trends显示文摘 | Dobre O A Abdi A Bar Ness Y | 2007 | IET Communications2007，1，2： | 1 |
| 6 | N - terminal pro - B - type natri- uretic peptide:reference plasma levels from birth to adolescence:El- evated levels at birth and in infants and children with heart diseases 显示文摘 | Nir A Bar O B Perles Z | 2004 | Acta Paediatr2004，93，5： | 1 |
| 7 | Endoscopic mechanical retrieval of sialoliths 显示文摘 | Nahlieli O Shacham R Bar T | 2003 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2003，95，4： | 1 |
| 8 | Composition and stereochemistry of ephedrine alkaloids accumulation in Ephedra sinica Stapf显示文摘 | Krizevski R Bar E Shalit O | 2010 | Phytochemistry2010，71，89： | 1 |
| 9 | Direct gear tooth contact analysis for hypoid bevel gears 显示文摘 | Vogel O Griewank A Bar G | 2002 | Computer Methods in Applied Mechanics and Engineering2002，191，36： | 1 |
| 10 | Guidelines on the management of valvular heart disease (version 2012) 显示文摘 | Vahanian A Alfieri O Andreotti F Antunes M J Barón-Esquivias G Baumgartner H | 2012 | Eur Heart J2012，33，： | 1 |
| 11 | Characterization of monascidin A from Monascus as citrinin显示文摘 | P J Blanc J P Laussac J L Bars P L Bars M O Lotet A Pareilleux D Prome J C Prome A L Santerre G Goma | 1995 | International Journal of Food Microbiology1995，27，： | 1 |
| 12 | Pregnancy outcome after cyclosporine therapy during pregnancy:a meta-analysis显示文摘 | Bar O B Hackman R Einarson T | 2001 | Transplantation2001，71，8： | 1 |
| 13 | Modelling Dynamic Spatial Processes:Simulation of Urban Future Scenarios Through Cellular Automata显示文摘 | JOSE I BARRED O MARJO K | 2003 | Landscape and Urban PLanning2003，64，： | 1 |
| 14 | The Status of Dual Path Litigation in the ITC and the Courts:Issues of Jurisdiction显示文摘 | Ritscher Tramposch O'Connell Bar ons | 1990 | Res Judicata and Appellate Review1990，，18： | 1 |
| 15 | Endoscopic mechanical retrieval of sialoliths显示文摘 | Shacham R Bar T | 2003 | Oral Surg Oral Med Oral Pathol2003，95，4： | 1 |
| 16 | A survey of automatic modulation classification techniques: classical approaches and new trends显示文摘 | Dobre O A Abdi A Bar Ness Y | 2007 | IET Communication2007，1，2： | 1 |
| 17 | Survey of automatic modulation classification techniques: clas- sical approaches and new trends 显示文摘 | DOBRE O A ABDI A BAR - NESS Y | 2007 | IET Commum2007，1，2： | 1 |
| 18 | Management of chronic recurrent parotitis:current therapy显示文摘 | Bar T Sbacbam R | 2004 | J Oral Maxillofac Surg2004，62，： | 1 |
| 19 | Survey of Automatic Modulation Classification Techniques: Classical Approaches and New Trends 显示文摘 | DOBRE O A ABDI A BAR Ness Y | 2007 | IET Communications2007，1，2： | 1 |
| 20 | Maternal hyperthermia and the risk for neural tube defects in offspring: Systematic review and meta-analysis显示文摘 | Moretti M E Bar O Fried S | 2005 | Epidemiology2005，16，2： | 1 |
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