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17篇 您的检索式:作者名="BARRIL X"
    题名 作者 年代 出处 被引量
1Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms 显示文摘Wright L Barril X Dymoek B 2004Chem Bi- d2004,11,6:1
24,5-diarylisoxazole Hsp90 chaperone inhibitors:potential therapeutic agents for the treatment of cancer显示文摘Brough PA Aherne W Barril X 2008J Med Chem2008,51,2:1
3Unveiling the Full Potential of Flexible Receptor Docking Using Multiple Crystallographic Structures显示文摘Barril X Morley D 2005J Med Chem2005,48,:1
4Combining hit identi- fication strategies: fragment-based and in silico approaches toorally active 2-aminothieno pyrlmicline inhibitors of the Hsp90 molecular chaperone显示文摘Brough PA Barril X Borgognoni J 2009J Med Chem2009,52,15:1
5Unveiling the full potential of flexible receptor docking using multiple crystallographic structures 显示文摘Barril X Morley S D 2005Journal of Medicinal Chemistry2005,48,44:1
6Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 dis- covered through structure-based design显示文摘DYMOCK BW BARRIL X BROUGH PA 2005J Med Chem2005,48,13:1
7Molecular simulation methods in drug discovery:a prospective outlook显示文摘Barril X Javier Luque F 2012J Comput Aided Mol Des2012,26,:1
8Novel, potent small-molecule inhibitors of the mo- lecular chaperone Hsp90 discovered through struc- ture-based design显示文摘DYMOCK B W BARRIL X BROUGH P 2005J Med Chem2005,48,13:1
93- ( 5-Chloro-2, 4-dihydroxyphenyl )-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone显示文摘BROUGH P A BARRIL X BESWICK M 2005Bioorg Med Chem Lett2005,15,23:1
10Structure-based discovery of a new class of Hsp90 inhibitors 显示文摘BARRIL X BROUGH P DRYSDALE M 2005Bioorg Med Chem Lett2005,15,23:1
11Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design 显示文摘DYMOCK B W BARRIL X BROUGH P A 2005J Med Chem2005,48,13:1
124- Amino derivatives of the Hspg0 inhibitor CCT018159显示文摘BARRIL X BESWICK M C COLLIER A 2006Bioorg Med Chem Lett2006,16,9:1
13A Xuorescenee polarization assay for inhibitors of Hsp90 显示文摘HOWES R BARRIL X DYMOCK BW et ul 2006Anal Biochem2006,350,2:1
144, 5-Diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer显示文摘Brough P A Aherne W Barril X 2008J Med Chem2008,51,2:1
15Structure-activity relationships in purine-based inhibitor binding to Hsp90 isoforms显示文摘Wright L Barril X 2004Chem Biol2004,11,6:1
16Combining hit identification strategies: Fragment-based and in sili co approaches to orally active 2-aminothienopyrimidine inhibitors of the Hsp90 molecular chaperone显示文摘Brough P A Barril X Borgognoni J 2009J Med Chem2009,52,:1
17Structure-activity rela tionships in purine-based inhibitor binding to hsp90 isoforms 显示文摘Wright L Barril X Dymock B etal 2004Chem Biol2004,11,6:1
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