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16篇 您的检索式：作者名="BARSH J"

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		题名	作者	年代	出处	被引量
	1	Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model.	Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss	2008	World Journal of Gastroenterology2008，14，44：	4
	2	How E- tailingcan rise from the ashes 显示文摘	BARSH J CRAWFORD B GROSSO C	2000	The mckinsey quarterly2000，，3：	1
	3	Modulation of murine melanocyte function in vitro by agouti signal protein 显示文摘	Sakai C OM Kobayashi T Abdel - Malek Z Muller J Vieira WD lmokawa G Barsh GS Hearing VJ	1997	EMBO J1997，16，35：	1
	4	A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein显示文摘	Larsson N G Garman J D Oldfors A Barsh G S Clayton D A		0，，03：	1
	5	Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans显示文摘	Larsson N G Oldfors A Garman J D Barsh G S Clayton D A		0，，02：	1
	6	Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice显示文摘	Larsson N G Wang J Wilheimsson H Oldfors A Rustin P Lewandoski M Barsh G S		0，，03：	1
	7	Liver ischemia and ischemia-reperfusion induces and trafficks the multi-specific metal transporter Atp7b to bile duct canaliculi:possible preferential transport of iron into bile显示文摘	Goss J A Barshes N R Karpen S J	2008	Biol Trace Elem Res2008，122，1：	1
	8	Isolated orthotop icliver transplantation for parenteral nutrition associated liver injury显示文摘	Barshes NR Carter BA Karpen S J	2006	JPEN J Parenter Enteral Nutr2006，30，6：	1
	9	Unlocking the full potential of women in the US economy显示文摘	Barsh J Yee L	2011	Mc Kinsey&Company2011，，：	1
	10	Association of an Agouti allele with fawn or sable coat color in domestic dogs显示文摘	Berryere T G Kerns J A Barsh G S	2005	Mamm Genome2005，16，4：	1
	11	The mouse mahogany locus encodes a transmembrane form of human at tractin显示文摘	Miller K A He L Hyman R W Davis R W Azara ni A Schlossman S F Duke-Cohan J S Barsh G S	1999	Nature1999，398，：	1
	12	D-dimer levels remain elevated in acute aortic dissection after 24 h显示文摘	Albini P Barshes N R Russell L Wu D Coselli J S Shen Y H	2014	J Surg Res2014，191，：	1
	13	A biochemical function for attractin in agouti-induced pigmentation and obesity显示文摘	Gunn T M Bouley D M Lu X Y Watson S J Schloss man S F Duke-Cohan J S Barsh G S	2001	Nat Genet2001，27，：	1
	14	Secreted and membrame attractin resultfrom alternative splicing of the human ATRN gene显示文摘	Gunn T M McLaughlin D F Barsh G S SchlossmanS F Duke-Cohan J S	2000	ProcNatl Acad Sci U S A2000，97，：	1
	15	Spongiform neurodegen-eration-associated E3 ligase Mahogunin ubiquitylates TSG101 andregulates endosomal trafficking显示文摘	Kim B Y Olzmann J A Barsh G S	2007	Mol Biol Cell2007，18，4：	1
	16	Distribution of Mahogany/Attractin mRNA in the rat central nervous sys tem显示文摘	Gunn T M Barsh G S Akil H Watson S J	1999	FEBS Lett1999，462，：	1

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