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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Microcystin-LR Causes the Collapse of Actin Filaments in Primary Human Hepatocytes显示文摘 | Batista T Sousa G D Suput S | 2003 | Aquatic Toxicology2003，65，： | 1 |
| 3 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 4 | Antionxidant properties of proanthocyanidins of Uncaria to mentosa bark decoction:a mechanism for anti-inflammatory activity显示文摘 | Goncalves C Dinis T Batista MT | 2005 | Phytochemistry2005，66，1： | 1 |
| 5 | Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats:involvement of Ach-M3R,Synt 1 and SNAP-25 proteins显示文摘 | BATISTA T M RIBEIRO R A AMARAL A G | 2012 | Journal of Nutritional Biochemistry2012，23，： | 1 |
| 6 | Functional and antioxidative properties of protein hydrolysates from Cape hake by- products prepared by three different methodologies显示文摘 | Pires C Clemente T Batista I | 2012 | Journal of the Science of Food and Agriculture2012，93，4： | 1 |
| 7 | Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 and 2 HEV strains are prevalent in the respective human populations显示文摘 | Cooper K Huang F F Batista L Rayo C D Bezanilla J C Toth T E Meng X J | 2005 | J Clinic Microbiol2005，43，4： | 1 |
| 8 | Microcystin-LR cause the collapse of actin filaments in primary human hepatocytes 显示文摘 | Batista T Georges de Sousa Suput JS | 2003 | Aquatic Toxicol2003，65，1： | 1 |
| 9 | The Pht1;9 and Pht1;8 transporters mediate inorganic phosphate acquisition by theArabidopsis thaliana root during phosphorus starvation显示文摘 | Remy E Cabrito T R Batista R A | 2012 | New Phytol2012，195，2： | 1 |
| 10 | Yield estimation of sugarcane based on agro meteorological spectral models显示文摘 | Rudorff B F T Batista G T | 1990 | Remote Sensing of Environment1990，33，3： | 1 |
| 11 | Wheat yield estimation at the farm level using TM Landsat and agrometeorological data显示文摘 | Rudorff B F T Batista G T | 1991 | International Journal of Remote Sensing1991，12，12： | 1 |
| 12 | Wheat yield estimation at the farm level using TM landsat and agrometeorological data显示文摘 | Rudorff B F T Batista G T | 1991 | International Journal of Remote Sensing1991，12，12： | 1 |
| 13 | Cataly-sis of Formaldehyde Oxidation By Electrodeposits of PtRu显示文摘 | Lima R B Massafera M P Batista E A Iwasita T | 2007 | Electroanal Chem J2007，603，1： | 1 |
| 14 | Antionxidant properties of proanthocyanidins of Uncaria to mentosa bark decoction:a mechanism for anti-inflammatory activity显示文摘 | Goncalves C Dinis T Batista MT | 2005 | Phytochemistry2005，，1： | 1 |
| 15 | Hospital volume and surgical mortality in the United States显示文摘 | Birkmeyer J D Siewers A E Finlayson E V Stukel T A Lucas F L Batista I | 2002 | N Engl J Med2002，346，： | 1 |
| 16 | Microarray analy- ses revealthat plant mutagenesis may induce more tran- scriptomic changesthan transgene insertion 显示文摘 | Batista R Saibo N Lourenco T | 2008 | Proc Natl Acad Sci USA2008，105，36： | 1 |
| 17 | Catalytic wet-air oxidation of a- queous solutions of formic acid, acetic acid and phenol in a con- tinuous-flow trickle-bed reactor over Ru/TiO2 catalysts显示文摘 | Pintar A Batista J Ti ler T | 2008 | Ap- plied Catalysis B: Environmenta]2008，84，12： | 1 |
| 18 | Corrosion, wear and wear- corrosion behavior of graphite- like a-C: H films deposited on bare and nitrided titanium alloy显示文摘 | Manhabosco T M Barboza A P M Batista R J C | 2013 | Diamond and Related Materials2013，31，： | 1 |
| 19 | Microcystin-LR causes the collapse of actin filaments in primary human hepatocytes显示文摘 | BATISTA T DE SOUSA G SUPUT J S | 2003 | Aquatic Toxicology2003，65，1： | 1 |
| 20 | On the HHT, its prob-lems, and some solutions 显示文摘 | Rato R T Ortigueira M D Batista A G | 2008 | Mechanical Systems and SignalProcessing2008，22，： | 1 |
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