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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Heavy Metal Lead Exposure, Osteoporotie-like Phenotype in an Animal Model, and Depression of Wnt Signaling显示文摘 | Beier E E Maher J Sheu T J | 2013 | Environ Health Perspeet2013，121，1： | 1 |
| 3 | Advances in alcoholic liver disease显示文摘 | Beier J I Arteel G E McClain C J | 2011 | Curt Gastroenterol Rep2011，13，1： | 1 |
| 4 | The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the e-kit receptor, the gene product of theW locus显示文摘 | Huang E Nocka K Beier D R | 1990 | Cell1990，63，： | 1 |
| 5 | The hematopoietic growth factor KL is encoded at the SL locus and is the ligand of c-kit receptor, the gene produce of the W locus显示文摘 | Huang E Nocka K Beier D R | 1990 | Cell1990，63，： | 1 |
| 6 | CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma显示文摘 | Coiffier B Lepage E Beiere J | 2002 | N Engl J Med2002，346，： | 1 |
| 7 | Host density predicts presence of cuckoo parasitism in reed warblers显示文摘 | Stokke BG Hafstad I Rudolfsen G Bargain B Beier J Campàs DB Dyrcz A Honza M Leisler B Pap PL Patapavicius R Procházka P Schulze-Hagen K Thomas R Moksnes A M(o)ller AP R(o)skaft E Soler M | | 0，，： | 1 |
| 8 | Totenstarremessungen an menschlichen skelett-muskeln in situ 显示文摘 | Liebhardt E Schuck M | 1977 | ZRechtsmed1977，79，： | 1 |
| 9 | Psoralen and other linear furanocoumarins as phytoatexins in celery (Apium grareolens) 显示文摘 | Beier R C Oertli E H | 1983 | Phytochemistry1983，22，： | 1 |
| 10 | Forest structure and prey abundance in foraging areas of northern goshawks显示文摘 | Beier P Drennan J E | 1997 | Ecological Applications1997，7，2： | 1 |
| 11 | Association between human beta defensin expression and cholesteatoma formation显示文摘 | MEYER J E SCHWAAB M BEIER U H | 2006 | Auris Nasus Larynx2006，33，2： | 1 |
| 12 | Determination of 5' ends of specific mRNAs by DNA ligase-dependent amplification显示文摘 | Bertling W M Beier F Reichenberger E | 1993 | PCR Methods Appl1993，3，： | 1 |
| 13 | The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor,the gene product of the W locus显示文摘 | Huang E Nocka K Beier DR | 1990 | Cell1990，63，2： | 1 |
| 14 | Genomic organizationand full-length cDNA sequence of human collagen X显示文摘 | Reichenberger E Beier F Luvalle P | 1992 | FEBSLett1992，311，3： | 1 |
| 15 | Lead induces an osteoarthritislike phenotype in articular chondrocytes through disruption of TGF-βsignaling显示文摘 | Holz JD Beier E Sheu TJ | 2012 | J Orthop Res2012，30，11： | 1 |
| 16 | Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model显示文摘 | BEIER J P HORCH R E HESS A | | 0，，03： | 1 |
| 17 | Co-stimulatory, molecules as potential targets for therapeutic intervention in allergic airway disease显示文摘 | KALLINICH T BEIER K C GELFAND E W | 2005 | Clin Exp Allergy2005，35，12： | 1 |
| 18 | Die Verw rtterung yon Steinkoh-len 显示文摘 | KRGER C BEIER E | 1962 | Brennstoff-Chemie1962，43，4： | 1 |
| 19 | Effect of air annealing on the electronic properties of CdS/Cu(In,Ga)Se2 soalar cells显示文摘 | MOONS E GAL D BEIER J | | 0，，： | 1 |
| 20 | Die Verwrtterung yon teinkoh - len 显示文摘 | Kroger C Beier E | 1962 | Brennstoff- Chemie1962，43，4： | 1 |
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