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| 1 | New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samples显示文摘瞄准:识别一多象用为肝纤维变性(F1-F2 ) 的察觉和区别的提高表面的激光 desorption/ionisation time-of-flight 团 spectrometry (SELDI-TOF-MS ) 的单个蛋白质标记一样的浆液蛋白质模式,在有长期的丙肝病毒(HCV ) 的病人的肝肝硬化(F4 ) andhepatocellular 癌(HCC ) 。方法:有 F1/F2 纤维变性的 39 个病人,的 Serumsamples 有 F4 纤维变性的 44 个病人,有我们重新申请到 CM10 数组并且分析了使用 SELDI-TOF ProteinChip 系统的 HCC 的 34 个病人(PBS-IIc;CiphergenBiosystems ) 在阴离子交换分别以后。所有病人 andhistologically 有长期的丙肝证实的纤维变性 stage/HCC。数据被 multivariatestatistical 技术和人工的神经网络为蛋白质模式分析。结果:4 肽 / 蛋白质 multimarkerpanel (7486, 12843, 44293 和 53598 Da ) 正确地在训练样品(AUROC0.943 ) 的 HCV 肝硬化对 HCV-HCC 的二方法比较与 100% 的敏感和 85% 的特性识别了 HCC。为 HCC 的鉴定的敏感和特性为随机的测试样品是 68% 和 80% 。肝脏硬化症的病人能被歧视有多使用 5peptide/protein 的 F1 或 F2 纤维变性的病人标记模式( 2873 , 6646 , 7775 , 10525 和 67867 Da )与100%和在训练样品( AUROC 0.976 )的85%的敏感和敏感和特性of80%的特性并且67%为随机的测试样品。有 APRI 分数 andalfa-fetopotein (法新社) 的简历标记分类器的联合改进了诊断表演。为肝纤维变性的 6646 Da 标记蛋白质作为 apolipoprotein C-I 被识别。结论:与蛋白质模式分析相结合的 SELDI-TOF-MS 技术与长期的丙肝在病人为肝肝硬化 andhepatocellular 癌的鉴定似乎是一条珍贵途径。最可能,不同浆液标记的联合将帮助以后识别肝肝硬化和早阶段的 hepatocellularcarcinomas。 | Thomas Gbel Sonja Vorderwülbecke Katarzyna Hauck Holger Fey Dieter Hussinger Andreas Erhardt | 2006 | World Journal of Gastroenterology2006，12，47： | 21 |
| 2 | Morphological and genetic comparison of two strains of a Prorocentrum species isolated from Zhejiang coastal water of China and Masan Bay of Korea显示文摘In this paper, we examined the detailed morphology of two strains of Prorocentrum isolated from the coastal waters of Zhejiang (Wenling area), China, and Masan Bay of Korea. A taxonomic comparison was made among strains on the basis of morphological and molecular data. The cellular dimensions of the Chinese Wenling strain (LAMB090508) and Korean strain (PDKS0206) were similar and the cells of both strains were of asymmetric and elongated shape. The posterior end of most cells was rounded. Megacytic zones of aged cells were broader with dense tiny knobs. The roundish nucleus was located in the posterior part of the cell. A few irregular shaped chloroplasts were distributed within the cell. The nucleotide similarity of the two strains, determined from the 5.8S rDNA-ITS sequences, was 99.83%. The comparative results of morphology and molecular analysis suggest that both strains isolated from China and Korea were the identical species, Prorocentrum donghaiense Lu. | 陆斗定 王红霞 黄海燕 夏平 戴鑫烽 GBEL Jeanette JEONG Hae Jin | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 3 |
| 3 | 东海陆架黑潮区鸟尾藻的分类及其生态分布特点显示文摘对东海陆架黑潮区及邻近海域的鸟尾藻进行了分类与生态分布研究 ,共检出 5种鸟尾藻 :大鸟尾藻、斯氏鸟尾藻、美丽鸟尾藻、赛氏鸟尾藻和方鸟尾藻。扫描电镜观察结果表明 ,鸟尾藻的纵沟左边翅是由两块边翅相连接而成 ,即由右下体边翅与纵沟左边翅相连而成。鸟尾藻分布的生物边界与暖水到达的位置相吻合 ,对东海黑潮及其台湾暖水水系具有显著的指示作用。 | 陆斗定 Jeanette Gbel | 2001 | 东海海洋2001，19，3： | 3 |
| 4 | Experimental Separation of Rashba and Dresselhaus Spin - Splittings in Semiconductor Quantum Wells 显示文摘 | Ganichev S D Bel'kov V V GoRlub L E Ivchenko E L Schneider P Giglberger S Eroms J DeBoeck J Borghs G Wegscheider W Weiss D Prettl W | | cond0，，： | 1 |
| 5 | Storm water runoff concentration matrix for urban areas显示文摘 | Góbel P Dierkes C Coldewey W G | | 0，，1： | 1 |
| 6 | Getting there fast : globalization, intercontinental flights and location of headquarters显示文摘 | Bel G Fageda X | 2008 | Journal of Economic Geography2008，8，4： | 1 |
| 7 | Transport,catabolism and release of histamine in the ruminal epithelium of sheep显示文摘 | ASCHENBACH J R OSWALD R GBEL G | 2000 | Journal of Physiology2000，440，1： | 1 |
| 8 | A Set of methods in transportation network synthesis and analysis 显示文摘 | DUBOIS D BEL G LIBRE M | 1979 | Journal of Operational Research Society1979，30，9： | 1 |
| 9 | Hsmstring/quadfieeps strength rations in col egiate middle-distance and distance runner显示文摘 | Morris A Lussier L Bel G | | 0，，： | 1 |
| 10 | Supply chain management:a supplier perspective显示文摘 | Rota K Thierry C Bel G | 2002 | Production Planning & Control2002，14，4： | 1 |
| 11 | Simulation of recrystallization by cellular automata显示文摘 | HESSELBARTH H W GBEL I R | 1991 | Acta Metallurgica et Materialia1991，39，： | 1 |
| 12 | Botulinum toxin A in the treatment of headache syndromes and pericranial pain syndromes显示文摘 | G bel H Heinze A Heinze-kuhn | 2001 | Pain2001，91，： | 1 |
| 13 | A set of methods in transportation network synthesis and analysis 显示文摘 | DUBOIS D BEL G LLIBRE M | 1979 | Journal of the Operational Research Society1979，30，9： | 1 |
| 14 | Expression of mRNA for glucose transport proteins in jejunum,liver,kidney and skeletal muscle of pigs显示文摘 | Aschenbach J Steglich K G?bel G | | 0，，03： | 1 |
| 15 | A parameterization of low visibilities for hazy days in the North China Plain显示文摘 | Chen J. Zhao C. S. Ma N. Liu P. F. G?bel T. Hallbauer E. Deng Z. Z. Ran L. Xu W. Y. Liang Z. Liu H. J. Yan P. Zhou X. J. Wiedensohler A | 2012 | 2012 (271)2012，，271： | 1 |
| 16 | Preparation of lithium-boron al oys:electrochemical studies as anodes in molt en salt media and comparisonwith pure lithium-involving syst ems显示文摘 | Sanchez P Bel in C Crepy G | | 0，，： | 1 |
| 17 | The isothermal-oxidation behavior of several nickel-base single-crystal superalloys with and without coatings显示文摘 | M. G?bel A. Rahmel M. Schütze | 1993 | Oxidation of Metals (-)1993，，3： | 1 |
| 18 | lntermunicipal cooperation, privatization and waste management costs: evidence from rural municipalities 显示文摘 | BEL G MUR M | 2009 | Waste Management2009，29，10： | 1 |
| 19 | Evaluation of color alterations on fabrics by image analysis 显示文摘 | XU B G BEL P | 2009 | AATCC Review2009，9，10： | 1 |
| 20 | Trace determination of macrolide and sulfonamide antimicrobials, a human sulfonamide metabolite, and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry显示文摘 | G BEL A MCARDELL C S SUTER M J F | 2004 | Analytical Chemistry2004，76，16： | 1 |
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