|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Finite Element Analysis and Design in Stainless Steel Sheet Forming and Its Experimental Comparison 显示文摘 | Li P L Sang M H Beom S K | 2001 | Journal of Materials Processing Technology2001，110，1： | 1 |
| 3 | TMS-OTi-Catalyzed abromination of carbonyl compounds by N-bromosuccinimide 显示文摘 | Samar K G Bo W Beom S K | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 4 | Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes 显示文摘 | Choi MS Yun S J Beom H J | 2011 | J Dermatol2011，38，： | 1 |
| 5 | Electrical fracture toughness for a conducting crack in ferroelectric ceramics显示文摘 | Beom H K Youn S K | 2004 | Int J Solids Struct2004，41，： | 1 |
| 6 | Finite element analysis and modeling of structure with bolted joints显示文摘 | Jeong K Joo-Cheol Y Beom S K | 2007 | Science Direct2007，，31： | 1 |
| 7 | Finite element analysis and modeling of structure with bolted joints 显示文摘 | Jeong K Joo C Y Beom S K | 2007 | Applied Mathematical Modellingm2007，，31： | 1 |
| 8 | Effect of Chemical Struc- ture on the Crosslinking Behavior of Bismaleimides : Rheologi- cal Study显示文摘 | JUNG O P BEOM J Y MOHAN S | 2011 | Journal of Non-newtonian Fluid Mechanics2011，166，： | 1 |
| 9 | Near-tip fields and intensity factors for interfacial cracks in dissimilar anisotropic piezoelectric media显示文摘 | Beom H G Atluri S N | 1996 | International Journal of Fracture1996，75，2： | 1 |
| 10 | Development of an authoring framework for the simplified customization of PDM systems 显示文摘 | Inho S Jeongsam Y Beom P | 2008 | Journal of Mechanical Science and Technology2008，22，11： | 1 |
| 11 | Root Treatmentwith Rhizobacteria Antagonistic to Phytophthora blight AffectsAnthracnose Occurrence,Ripening,and Yield of Pepper Fruit inthe Plastic House and Field显示文摘 | MEE K S JEONG D K BEOM S K | 2011 | Phytopathology2011，101，6： | 1 |
| 12 | A sensor-based navigaton for a mobile robot using fuzzy logic and reinforcement learning显示文摘 | Beom H R Cho H S | 1995 | IEEE Transactions on Systems Man and Cybernetics1995，，5： | 1 |
| 13 | Effect of BaSnO3 on the microwave dielectric properties of BazTigO20 显示文摘 | YOON H K BEOM K J WOO S K | 1996 | J Mater Res1996，11，8： | 1 |
| 14 | Mobile robot localization using a single rotating sonar and two passive cylindrical beacons显示文摘 | BEOM H R CHO H S | 1995 | Robotics1995，13，： | 1 |
| 15 | High cell density fed-batch cultivation of Escherichia coil using exponential feeding combined with pH-star显示文摘 | BEOM S K SEUNG C L SANG Y L | 2004 | Bioprocess Bio-systems Engineering2004，26，： | 1 |
| 16 | Cale-ulation of stress intensity factors for an interracial crack between dissimilar aniso-tropie media, using a hybrid element methodand the mutual integral 显示文摘 | Chow W T Beom H G Atluri S N | 1995 | Computational Mechanics1995，15，： | 1 |
| 17 | A study on the framework for survivability assessment system of damaged ships显示文摘 | DONGKON L SOON S L BEOM J P | 2005 | Ocean Engineering2005，32，1： | 1 |
| 18 | Synthesis of nanoparticute silica composite embraces by the pressurized sol-gel technique 显示文摘 | Sang H Beom S K | 1994 | J Am Ceram Soc1994，77，12： | 1 |
| 19 | Near-tip fields and intensity factors for interfacial cracks in dissimilar anisotropic piezoelectric media 显示文摘 | Beom H G Atluri S N | 1996 | International Journal Fracture1996，75，： | 1 |
| 20 | TMS-OTf-catalyzed α- bromination of carbonyl compounds by N-bromosuccinimide 显示文摘 | Samar K G Bo W Beom S K | 2006 | Tetrahedron Letters2006，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员