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| 1 | Redefining Budd-Chiari syndrome:A systematic review显示文摘AIM:To re-examine whether hepatic vein thrombosis(HVT)(classical Budd-Chiari syndrome)and hepatic vena cava-Budd Chiari syndrome(HVC-BCS)are the same disorder.METHODS:A systematic review of observational studies conducted in adult subjects with primary BCS,hepatic vein outflow tract obstruction,membranous obstruction of the inferior vena cava(IVC),obliterative hepatocavopathy,or HVT during the period of January2000 until February 2015 was conducted using the following databases:Cochrane Library,CINAHL,MEDLINE,Pub Med and Scopus.RESULTS:Of 1299 articles identified,26 were included in this study.Classical BCS is more common in women with a pure hepatic vein obstruction(49%-74%).HVCBCS is more common in men with the obstruction often located in both the inferior vena cava and hepatic veins(14%-84%).Classical BCS presents with acute abdominal pain,ascites,and hepatomegaly.HVC-BCS presents with chronic abdominal pain and abdominalwall varices.Myeloproliferative neoplasms(MPN)are the most common etiology of classical BCS(16%-62%)with the JAK2V617-F mutation found in 26%-52%.In HVCBCS,MPN are found in 4%-5%,and the JAK2V617-F mutation in 2%-5%.Classical BCS responds well to medical management alone and 1st line management of HVC-BCS involves percutaneous recanalization,with few managed with medical management alone.CONCLUSION:Systematic review of recent data suggests that classical BCS and HVC-BCS may be two clinically different disorders that involve the disruption of hepatic venous outflow. | Naomi Shin Young H Kim Hao Xu Hai-Bin Shi Qing-Qiao Zhang Jean Paul Colon Pons Ducksoo Kim Yi Xu Fei-Yun Wu Samuel Han Byung-Boong Lee Lin-Sun Li | 2016 | World Journal of Hepatology2016，8，16： | 6 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial显示文摘 | Sung-Bum Kang Ji Won Park Seung-Yong Jeong Byung Ho Nam Hyo Seong Choi Duck-Woo Kim Seok-Byung Lim Taek-Gu Lee Dae Yong Kim Jae-Sung Kim Hee Jin Chang Hye-Seung Lee Sun Young Kim Kyung Hae Jung Yong Sang Hong Jee Hyun Kim Dae Kyung Sohn Dae-Hyun Kim Jae H | 2010 | Lancet Oncology2010，，7： | 5 |
| 4 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 5 | Three- node triangular shell element based on the assumed natural strains显示文摘 | Young H Kim | 2002 | Computational Mechanics2002，29，： | 1 |
| 6 | 8-GHz Static Frequency Divider in AlInAs/InGaAs HBT Technology显示文摘 | Fields Charles H Stephen Thomas III Shi Binqiang Young Kim Boegeman Mary Montes Rosanna Martinez Kramer Allan R and Meena Madhav A Low-Power 72 | 2001 | IEEE JOURNAL OF SOLID-STATE CIRCUITS2001，36，： | 1 |
| 7 | A comparison of clinical outcomes with retrievable and permanent inferior vena cava filters显示文摘 | Kim H S Young M J Narayan A K | 2008 | J Vase Interv Radial2008，19，3： | 1 |
| 8 | Disruption of the myocardial extracellularmatrix leads to cardiac dysfunction显示文摘 | Kim H Dalal S Young E | | 0，，106： | 1 |
| 9 | Analysis of 13 phenolic compounds in aloe species by high performance liquid chromatography显示文摘 | PARK M K PARK J H NA YOUNG KIM | 1998 | Phytochemical Analysis1998，9，： | 1 |
| 10 | Surface Modification of Waterborne Polyurethane显示文摘 | YOUNG H LEE M H KIM B K | 2006 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2006，290，13： | 1 |
| 11 | Melatonin improves d- galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyms via in- creasing pCREB expression 显示文摘 | Young Y D Kim W Lee C H | 2012 | Journal of Pineal Re- search2012，52，： | 1 |
| 12 | Effect of Na Cl on Cr(Ⅵ)reduction by granular zero valent iron(ZVI)in aqueous solutions显示文摘 | Ahn H Young J H Kim G Y | 2012 | Materials Transactions2012，53，7： | 1 |
| 13 | Therapeutic time window for methylprednisolone in spinal cord injured rat显示文摘 | Yoon D H Kim Y S Young W | 1999 | Yonsei Med J1999，40，4： | 1 |
| 14 | Disruption of the myocardial extracellular matrix leads to cardiac dysfunction显示文摘 | Kim H E Dalai S S Young E | 2000 | J Clin Invest2000，106，7： | 1 |
| 15 | Modeling of the fate and effect of chlorinated phenols in anaerobic treatment processes 显示文摘 | Kim I S Tabak H H Young J C | 1997 | Water Science and Technology1997，36，67： | 1 |
| 16 | Clinical impact of thrombus aspiration during primary percutaneous coronary intervention: Results from Korea Acute Myocardial Infarction Registry显示文摘 | Daisuke Hachinohe Myung Ho Jeong Shigeru Saito Min Chol Kim Kyung Hoon Cho Khurshid Ahmed Seung Hwan Hwang Min Goo Lee Doo Sun Sim Keun-Ho Park Ju Han Kim Young Joon Hong Youngkeun Ahn Jung Chaee Kang Jong Hyun Kim Shung Chull Chae Young Jo Kim Seung Ho H | 2012 | Journal of Cardiology2012，，3： | 1 |
| 17 | Inorganic organic hybrid aanoporous materials as adsorbent to remove VOCs显示文摘 | KIM J H AN J H LA Y S JUNG J S JEONG H M KIM S M MOON N G LEE B W YOUNG H Y YOUNG C | 2008 | J Energy Chem2008，14，2： | 1 |
| 18 | The improvement of anticorrosion properties of zinc - rich organic coating by incorporating surfacemodified zinc particle显示文摘 | PARK J H TEA HO YUN KYOO YOUNG KIM | 2012 | Progress in Organic Coatings2012，74，： | 1 |
| 19 | Analysis of an asymmetrical piezoelectric annular bimorph using impedance and admitrance matrices显示文摘 | Sung K Ha Young H Kim | 2001 | J A S A2001，110，1： | 1 |
| 20 | Therapeutic time window for methylprednisolone in spinal cord injured rat 显示文摘 | Yoon D H Kim Y S Young W | 1999 | Yonsei Med J1999，40，4： | 1 |
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