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| 1 | Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates显示文摘AIM: To investigate the prevalence of vacuolating cytotoxin (vacA), cytotoxin associated gene A (cagA) and blood adhesion binding antigen (babA2) genotypes of Helicobacter pylori (H pylori) isolates from Cuban dyspeptic patients. METHODS: DNA was extracted from H pylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specifi c primers for vacA (s1, s2, m1, m2), cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS: vacA alleles s1 , s2 , m1 and m2 were detected in 96 (73.8%), 34 (26.2%), 75 (57.7%) and 52 isolates (40%), respectively, while the cagA gene was detected in 95 isolates (73.2%). One hundred and seven isolates (82.3%) were babA2-positive. A signif icant correlation was observed between vacAs1m1 and cagA and between vacAs1m1 and babA2 genotypes (P < 0.001 and P < 0.05, respectively) and between babA2 genotype and cagA status (P < 0.05); but, no correlation was observed between vacAs1 and babA2 genotypes. Eighty fi ve (65.4%) and 73 (56.2%) strains were type 1 (vacAs1-cagA-positive) and 'triple- positive' (vacAs1-cagA-babA2-positive), respectively, and their presence was significantly associated with duodenal ulcer (P < 0.01 and P < 0.001, respectively). CONCLUSION: The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were signifi cantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied. | Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín Hernández Ludisleydis Bermúdez Boris L Rodríguez | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 2 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 3 | Targeted treatments for cervical cancer:a review显示文摘 | PERALTA-ZA RAGOZA O BERM(U)DEZ-MORALES VH P(E)REZ-PLASENCIA C | | 0，，03： | 1 |
| 4 | Serum calcium metabolism in acute experimental pancreatitis显示文摘 | IZQUIERDO R BERMES E SANDBERG L | 1985 | Surgery1985，98，： | 1 |
| 5 | Serum calcium metabolism in acute experimental pancreatitis显示文摘 | IZQUIERDO R BERMES E SANDBERG L | 1985 | Surgery1985，98，： | 1 |
| 6 | Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell显示文摘 | Juan Picó P Fuentes E Bermúdez Silva FJ | 2006 | Cell Calcium2006，39，2： | 1 |
| 7 | Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection - California, April-May, 2009显示文摘 | Louie J Winter K Harriman K Vugia D Glaser C Matyas B Schnurr D Guevara H Pan C Y Saguar E Berumen R Hunley E Messenger S Preas C Hatch D Chavez G Kriner P Lopez K Sunega D Rexin D Roach S Kempf J Gonzalez R Morgan L Barnes N Berm | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，19： | 1 |
| 8 | Effect of in vitro hemolysis on chemical values for serum显示文摘 | FRANK J J BERMES E W BICKEL M J | 1978 | Clin Chem1978，24，11： | 1 |
| 9 | On the Effect of Li Diffusion in Er-doped Bulk Periodic Poled Lithium Niobate Crystals 显示文摘 | Bermúdez Callejo D Caccavale F Diéguez E | 1999 | Journal of Crystal Growth1999，205，： | 1 |
| 10 | Influence of phosphorus on Cu sorption kinetics:Stirred flow chamber experiments显示文摘 | P(E)REZ-NOVO C FERN(A)NDEZ-CALV(I)NO D BERM (U)DEZ-COUSO A | | 0，，： | 1 |
| 11 | Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell显示文摘 | Juan-Picó P Fuentes E Berm(u)dez-Silva FJ | 2005 | Cell Calcium2005，39，： | 1 |
| 12 | 1-N alkyl-3-methylimidazolium ionic liquids as neat lubricants and lubricant additives in steel-aluminium contacts显示文摘 | Jiménez A E Bermúdez M D Iglesias P | | 0，，07： | 1 |
| 13 | Study of surface interactions of ionic liquids with aluminium alloys in corrosion and erosion-corrosion processes 显示文摘 | BERM UDEZ M D JIM ENEZ A E MART INEZ N G | 2007 | Ap- plied surface science2007，253，17： | 1 |
| 14 | Virtual reality based rehabilitation speeds up functional recovery of the upper extremities after stroke:A randomized controlled pilot study in the acute phase of stroke using the Rehabilitation Gaming System显示文摘 | Da Silva Cameiro M Bermúdez IBadia S Duarte E | 2011 | Restorative Neurology and Neuroscience2011，29，5： | 1 |
| 15 | Study of surface interactions of ionic liquids with aluminium alloys in corrosion and erosion-corrosion processes显示文摘 | Bermúdez M D Jiménez A E Martinez-Nicolás G | 2007 | Appl Surf Sci2007，253，： | 1 |
| 16 | A decision support system methodology for forecasting of time series based on soft computing显示文摘 | BERM~DEZ J D SEGURA J V VERCHER V E | 2006 | Computational Statistics & Data Analysis2006，51，1： | 1 |
| 17 | Roomtemperature ionic liquids as lubricant additives in steel-alumin-ium contacts:influence of sliding velocity,normal load and tem-perature显示文摘 | JIMéNEZ A E BERMúDEZ M D CARRIóN F J | 2006 | Wear2006，261，34： | 1 |
| 18 | Renal and hepatic output of glutathione in plasma and whole blood显示文摘 | DASS P D BERMES E W HOLMES E W | 1992 | Biochim Bio- phys Acta1992，1156，1： | 1 |
| 19 | Imidazoliumionic liquids as additives of the synthetic ester propylene glycol dioleate in aluminium-steel lubrication显示文摘 | Jiménez A E Bermúdez M D | 2008 | Wear2008，265，： | 1 |
| 20 | Non-linear fourth order image interpolation for sub pixel edge detection and lo- ealization显示文摘 | HE RMOSILLA BERM BALAGUER A | 2008 | Image and Vision Computing2008，26，9： | 1 |
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