|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells显示文摘Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya Juan R Tejedo | 2017 | World Journal of Stem Cells2017，9，2： | 2 |
| 2 | Effect of surface passivation on performance of A1GaN/GaN/Si HEMTs 显示文摘 | BERNAT J JAVORKA P FOX A | 2003 | Solid-State Electronics2003，47，11： | 1 |
| 3 | Clinical significance ofantibiotic therapy of surgical disvases显示文摘 | Jezioro Z Bernat M Bielawski J | 1962 | Polski Tygodnik Lvkarski1962，17，： | 1 |
| 4 | Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells显示文摘Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide(NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness. | Amparo Beltran-Povea Estefania Caballano-Infantes Carmen Salguero-Aranda Franz Martín Bernat Soria Francisco J Bedoya Juan R Tejedo Gladys M Cahuana | 2015 | World Journal of Stem Cells2015，7，3： | 1 |
| 5 | Nitrification at low oxygen concentration in biofilm reactor 显示文摘 | Bernat N Dangkong N Delgenes J P | 2001 | J Environ Eng2001，127，3： | 1 |
| 6 | Clopidogrel hychrogensulfate 显示文摘 | HERBERT J M FRENEL D BERNAT A | 1993 | Drugs Fut1993，18，2： | 1 |
| 7 | Quantitative analysis of backlit shadowgraphy as a diagnostic of hydrogen ice surface quality inICF capsules显示文摘 | Koch J A Bernat T P Collins G W | 2000 | Fusion Sci Technol2000，38，： | 1 |
| 8 | The anti- aggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit 显示文摘 | HERBERT J M DOL F BERNAT A | 1998 | Thromb Haemost1998，80，3： | 1 |
| 9 | Informed consent显示文摘 | BERNAT J L | 2001 | Muscle Nerve2001，24，： | 1 |
| 10 | Decomposing ERP time-frequency energy using PCA显示文摘 | BERNAT E M WILLIAMS W J GEHRING W J | 2005 | Clinical Neurophysiology2005，116，： | 1 |
| 11 | The concept and practice of brain death显示文摘 | BERNAT J L | 2005 | Progress in Brain Research2005，，： | 1 |
| 12 | A study of the ethical duty of physicians to disclose errors显示文摘 | Sweet M P Bernat J L | 1997 | The Journal of Clinical Ethics1997，8，4： | 1 |
| 13 | Effect of surface passivation on performance of AIGaN/GaN/Si HEMTs显示文摘 | BERNAT J JAVORKA P FOX A | 2003 | Solid-State Electronics2003，47，11： | 1 |
| 14 | Forecasting of energy production and consumption in Asturias (Northern Spain)显示文摘 | Chavez G S Bernat X J | 1999 | Energy1999，24，： | 1 |
| 15 | Quantitative analysis of backlit shadowgraphy as a diagnostic of hydrogen ice surface quality in ICF capsules显示文摘 | Koch J A Bernat T P Collins G W | 2000 | Fusion Sci Technol2000，38，： | 1 |
| 16 | Nitrification at lowoxygen concentration in biofilm reactor显示文摘 | Bernat N Dangiong N Delgenes J P | 2001 | Environ Eng2001，127，3： | 1 |
| 17 | Nitrification at low oxygen concentration in biofilm reactor显示文摘 | Bernat N Dangiong N Delgenes J P | 2001 | Environ Eng2001，127，3： | 1 |
| 18 | Ethical and Quality Pitfalls in Electronic Health Records 显示文摘 | Bernat J L | 2013 | Neurology2013，80，11： | 1 |
| 19 | Evolution of binder strueture in soditm silicte-activated slag-metakataolin blends显示文摘 | Bernat S A Provis J L Rose V de Gutierrez R M | 2011 | Cement & Concrete Composites2011，33，： | 1 |
| 20 | Ethical aspects of disordered states of consciousness显示文摘 | Rubin E B Bernat J L | 2011 | Neurol Clin2011，29，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员