|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 2 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 4 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 5 | Effects of hyerinsulinemia on plasma levels of circulating adhesion molecules显示文摘 | Bernd J Susanne D Nicde H | 2000 | J Clin Endocrinol Metab2000，85，5： | 1 |
| 6 | Gender Differences in the Outcome of Cardiac Interventions显示文摘 | Prof. Dr. Harald Tillmanns Wolfgang Waas Reinhard Voss Erika Grempels Hans H?lschermann Werner Haberbosch Bernd Waldecker | 2005 | Herz Kardiovaskul?re Erkrankungen2005，，5： | 1 |
| 7 | A way to higher reso lution: spherical-aberration correction in a 200 kV transmis- sion electron microscope 显示文摘 | KNUT U BERND K MAX H | 1998 | Ultramicroscopy1998，75，1： | 1 |
| 8 | Synthesis,Structure and Properties of Liquid Crystalline Polymers显示文摘 | Engel Monica Bernd H Renate K | 1985 | Pure Appl Chem1985，57，7： | 1 |
| 9 | Antisense therapy in oncology:new hope for an old idea显示文摘 | INGO T BERND D GUNTHER H | 2001 | Lancet2001，358，9280： | 1 |
| 10 | In vitro and in vivo studies on blends of isotactic and atactic poly (3-hydroxybutyrate) for development of a dura substitute material显示文摘 | Kunze C Edgar Bernd H Androsch R Nischan C Freier T Kramer S | 2006 | Biomaterials2006，27，： | 1 |
| 11 | Accumulation of soluble and wall-bound indolic metabolites in Arabidopsis thaliana leaves infected with virulent or avirulent Pseudomonas syringae pathovar tomato strains 显示文摘 | Jens H Bernd S Neil JO | 2001 | PNAS2001，98，2： | 1 |
| 12 | Appearance of hepatocellular adenomas on gadoxetic acid-enhanced MRI显示文摘 | Timm Denecke Ingo G. Steffen Sheela Agarwal Daniel Seehofer Thomas Kr?ncke Enrique Lopez H?nninen Incken-Birthe Kramme Peter Neuhaus Sanjay Saini Bernd Hamm Christian Grieser | 2012 | European Radiology2012，，8： | 1 |
| 13 | Enhanced progenitor cell recruitment and endothelial repair after selective endothelial injury of the mouse kidney 显示文摘 | Bernd H Kuo MC Francesco A | 2010 | Am J Physiol Renal Physiol2010，298，6： | 1 |
| 14 | A Lateglacial and Holocene organic carbon isotope record of lacustrine palaeoproductivity and climatic change derived from varved lake sediments of Lake Holzmaar, Germany 显示文摘 | Andreas L Gerhard H S Bernd Z | 2003 | Quaternary Science Reviews2003，22，： | 1 |
| 15 | Mechanical spectroscopy of polymer :nagnelile composites 显示文摘 | Bernd W Werner R Lei Q H | 2004 | Materials Science and Engineering A2004，370，12： | 1 |
| 16 | Assessment of global left ventricular function comparison with cardiac multidetector-row computed tomography with angiocardiography显示文摘 | Walter H Karen S Bernd J W | 2005 | Comput Assist Tomogr2005，29，3： | 1 |
| 17 | Preclinical evaluation of inducible nitric oxide synthase lipoplex gene therapy for inhibition of stent-induced vascular neointimal lesion formation 显示文摘 | Andreas M Bernd H Jens S | 2003 | Hum Gene Ther2003，14，3： | 1 |
| 18 | Safety and tolerability of ultra-small super-paramagnetic iron oxide contrast agent: com- prehensive analysis of a clinical development program显示文摘 | Bernd H De Kerviler E Gaillard S | 2009 | Invest Radiol2009，44，6： | 1 |
| 19 | Experiential marketing显示文摘 | BERND H SCHMITT | 1999 | J Marketing Manage1999，15，13： | 1 |
| 20 | Speed4D technology -shifting paradigms in CT显示文摘 | Thomas F André H Bernd O | 2003 | Siemens Somatom Session2003，3，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员