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| 1 | H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression显示文摘AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents. | Valeska Portela Lima Marcos Antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst | 2008 | World Journal of Gastroenterology2008，14，6： | 17 |
| 2 | Effects of physiological integration on defense strategies against herbivory by the clonal plant Alternanthera philoxeroides显示文摘Aims The plant-herbivore interaction is one of the most fundamental inter-actions in nature.Plants are sessile organisms,and consequently rely on particular strategies to avoid or reduce the negative impact of herbivory.Here,we aimed to determine the defense strategies against insect herbivores in the creeping invasive plant Alternanthera philoxeroides.Methods We tested the defense response of A.philoxeroides to herbivory by a leaf-feeding specialist insect Agasicles hygrophila and a pol-yphagous sap-feeding insect Planococcus minor.We also tested the mechanisms triggering defense responses of A.philoxeroides by including treatments of artificial leaf removal and jasmonic acid application.Furthermore,we examined the effect of physiological integration on these defense strategies.Important Findings The combination of artificial leaf removal and jasmonic acid appli-cation produced a similar effect to that of leaf-feeding by the real herbivore.Physiological integration influenced the defense strat-egies of A.philoxeroides against herbivores,and increased biomass allocation to aboveground parts in its apical ramets damaged by real herbivores.Our study highlights the importance of physio-logical integration and modular plasticity for understanding the consequences of herbivory in clonal plants. | Rubén Portela Bi-Cheng Dong Fei-Hai Yu Rodolfo Barreiro Sergio R.Roiloa | 2019 | Journal of Plant Ecology2019，12，4： | 5 |
| 3 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 4 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 5 | Engineering operando methodology: Understanding catalysis in time and space显示文摘 | Raquel Portela Susana Perez-Ferreras Ana Serrano-Lotina Miguel A. Banares | 2018 | Frontiers of Chemical Science and Engineering2018，12，3： | 3 |
| 6 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Special situations显示文摘 | Gert Van Assche Axel Dignass Walter Reinisch C. Janneke van der Woude Andreas Sturm Martine De Vos Mario Guslandi Bas Oldenburg Iris Dotan Philippe Marteau Alessandro Ardizzone Daniel C. Baumgart Geert D’Haens Paolo Gionchetti Francisco Portela Boris Vuce | 2009 | Journal of Crohn’s and Colitis2009，，1： | 3 |
| 7 | Trans-generational effects in the clonal invader Alternanthera philoxeroides显示文摘近年的研究已经揭示出表型可塑性可以通过营养世代遗传。从这个意义上讲,环境诱导的基因调控变化(例如DNA甲基化,即表观遗传变异)会导致可逆的塑性反应传递给后代。这种跨世代的可塑性在克隆植物中尤其重要,因为有性繁殖减少会降低通过遗传变异进行适应的可能性。许多最具侵略性的植物入侵者都具有克隆性,而且克隆性被认为是植物入侵性的关键。本研究中,我们的目标是确定在克隆入侵者喜旱莲子草(Alternanthera philoxeroides)中是否发生了跨代效应,以及这种效应在本地和非本地群落之间是否存在差异。在同质园实验中,我们将采自巴西(原产地)和伊比利亚半岛(非原产地)的喜旱莲子草种群分别种植在养分高和低的土壤中,后代植株被移植到高养分条件下作为对照。为了检验DNA甲基化对跨代可塑性的潜在作用,一半的母株用去甲基化剂5-氮杂胞苷处理。在来自原产地和非原产地的种群中均观察到了跨代效应。有趣的是,在原产地种群的生长变量(分株数、茎生物量、根生物量和总生物量)中发现了跨代效应,而在非原产地种群中发现了生物量分配具有跨代效应。在原产地种群中出现的跨代效应可以用“银勺”效应来解释,而非原产地种群的跨代效应可以归因于DNA甲基化引起的表观遗传传递。本研究强调了跨代效应对克隆植物生长的重要性,这有助于理解众多克隆植物能够成功繁殖扩张的机制。 | Rubén Portela Bi-Cheng Dong Fei-Hai Yu Rodolfo Barreiro Sergio R.Roiloa Dalva MSilva Matos | 2020 | Journal of Plant Ecology2020，13，1： | 2 |
| 8 | A social approach to land consolidation schemes-A Portuguese case study: the Valenca Project显示文摘 | Coelho J C Portela J Pinto J A | 1996 | Land Use Policy1996，13，2： | 1 |
| 9 | The dual boundary element method:Effective implementation for crack problems显示文摘 | PORTELA A ALIABADI M H ROOK D P | 1992 | Int J Num Methods Eng1992，33，： | 1 |
| 10 | Effects of diazepam and stress on lung inflammatory responsein OVA-sensitized rats显示文摘 | Portela C D P Tibério I F L C Leick-Maldonado E A | 2002 | Am J Physiol Lung Cell Mol Physiol2002，82，： | 1 |
| 11 | Livertransplantation in a patient with Niemann-Pick disease and pulmonary involvement显示文摘 | Mendes MS Portela FX Reis RC | 2012 | [Article in English Portuguese] J Bras Pneumol2012，38，2： | 1 |
| 12 | Epigenetic modifications and human disease显示文摘 | Portela A Esteller M | 2010 | Nat Biotechnol2010，20，8： | 1 |
| 13 | 显示文摘 | Portela M F | 1995 | J Catal1995，157，： | 1 |
| 14 | A dynamic model of patterns of deforestation and their effect on the ability of the Brazilian Amazonia to provide ecosystem services显示文摘 | PORTELA R RADEMACHER I | 2001 | Ecological Modelling2001，143，： | 1 |
| 15 | Semi-supervised clustering for MR brain image segmentation显示文摘 | Portela N M Cavalcanti G D C Ren T I | 2014 | Expert Systems with Applications2014，41，4： | 1 |
| 16 | The adsorption of nitric oxide on supported Co-Mo hydrodesulfurization catalysts: A review显示文摘 | PORTELA L GRANGE P DELMON B | 1995 | Catal Rev: Sci Eng1995，37，4： | 1 |
| 17 | Anemia as a Predictor of Mortality in Patients with Decompensated Heart Failure显示文摘 | Paulo Atila da Silva Viana Vanessa Tavares Aragao Esther Carneiro Vasconeelos Bianca Ratts Freitas dos Santos Joaquim David Carneiro Neto Leandro Cordeiro Portela Jose Antonio de Lima Neto | 2018 | Journal of Pharmacy and Pharmacology2018，6，5： | 1 |
| 18 | Wind pressures and buckling of cylindrical steel tanks with a dome roof 显示文摘 | PORTELA G GODOY L A | 2005 | Journal of Constructional Steel Research2005，61，6： | 1 |
| 19 | Frame shift mutations as a novel mechanism for the generation of neutralization resistant mutants of human respiratory syncytial virns显示文摘 | Portela A Delgado T | 1990 | Embo J1990，9，： | 1 |
| 20 | Improved adhesion of polyethylene by copolymerisation of ethylene with polar monomers显示文摘 | SANTOS J M RIBEIRO M R PORTELA M F | 2001 | Chemical Engineering Science2001，56，13： | 1 |
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