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| 1 | Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota-Key players in the pathogenesis of celiac disease显示文摘Celiac disease(CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens(HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy. Although gluten is the main external trigger activating both innate and adaptive(specific) immunity, its presence in the intestinal lumen does not fully explain CD pathogenesis. It has been hypothesized that an early disruption of the gut barrier in genetically susceptible individuals, which would result in an increased intestinal permeability, could precede the onset of gluten-induced immune events. The intestinal barrier is a complex functional structure, whose functioning is dependent on intestinal microbiotahomeostasis, epithelial layer integrity, and the gutassociated lymphoid tissue with its intraepithelial lymphocytes(IELs). The aim of this paper was to review the current literature and summarize the role of the gut microbiota, epithelial cells and their intercellular junctions, and IELs in CD development. | Bozena Cukrowska Agnieszka Sowińska Joanna Beata Bierla Elzbieta Czarnowska Anna Rybak Urszula Grzybowska-Chlebowczyk | 2017 | World Journal of Gastroenterology2017，23，42： | 7 |
| 2 | Selenium metabolomics in yeast using complementary reversed-phase/ hydrophilic ion interaction (HILIC) liquid chromatogra- phy-electrospray hybrid quadrupole trap/Orbitrap mass spec- trometry显示文摘 | Amaudguihem C Bierla K Ouerdane L | 2012 | Analytica Chimica Acta2012，，： | 1 |
| 3 | Determination of selenocysteine and selenomethioninein edible animal tissues by 2D sizeexclusion reversed-phase HPLC-ICP MS following carbamidomethylation and proteolytic extraction显示文摘 | BIERLA K DERNVICS M VACCHINA V | 2008 | Anal Bioanal Chem2008，390，7： | 1 |
| 4 | New Evidence on Absen- teeism and Presenteeism显示文摘 | Bierla I Huver B Richard S | 2013 | The International Journal of Human Resource Management2013，24，7： | 1 |
| 5 | A novel cytometric approach to study intestinal mucosa rebuilding in weaned pigs fed with dietary nucleotides显示文摘 | Godlewski Michal M Bierla Joana B | | 0，，： | 1 |
| 6 | Determination of selenomethionine,selenocysteine and inorganic selenium in eggs by HPLC-inductively coupled plasma mass spectrometry显示文摘 | LIPIEC E SIARA G BIERLA K | | 0，，02： | 1 |
| 7 | Com- prehensive speciation of selenium in selenium-rich yeast显示文摘 | BIERLA K SZPUNAR J YIANNIKOURIS A | 2012 | Trac Trends in Analytical Chemistry2012，41，14： | 1 |
| 8 | Specific determination of selenoaminoacids in whole milk by 2D size - exclusion - ion - pairing reversed phase high - performance liquid chromatography - inductively coupled plasma mass spectrometry ( HPLC - ICP MS) 显示文摘 | Katarzyna Bierla Joanna Szpunar Ryszard Lobinski | 2008 | Analytic Chimica Acta2008，624，： | 1 |
| 9 | Selenium metabo- lomics in yeast using complementary reversed-phase/hydrophilic ion interaction ( HILIC ) liquid chromatography-electrospray hybrid quadrupole trap/Orbitrap mass spectrometry显示文摘 | Arnaudguilhem C Bierla K Ouerdane L | 2012 | Anal Chim Acta2012，757，： | 1 |
| 10 | Differences in spermatozoon: physiology or pathology?显示文摘 | BIERLA J B GIZEJEWSKI Z | 2007 | Medycyna Weterynaryjna2007，63，11： | 1 |
| 11 | SpeciationAnalysis for Trace Levels of Selenoproteins in CulturedHuman Cells 显示文摘 | Bianga J Touat-Hamici Z Bierla K | 2014 | J Proteomics2014，108，： | 1 |
| 12 | Specific Determination of Selenoaminoacids in Whole Milk by 2D Size-Exclusion-Ion-Pairing Reversed Phase High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry (HPLC-1CP MS)显示文摘 | Bierla K Szpunar J Lobinski R | 2008 | Analytic Chimica Acta2008，624，： | 1 |
| 13 | Specific Determination ofSelenoaminoacids in Whole Milk by 2D Size-Exclusion-Ion-Paring Reversed Phase High-Performance LiquidChromatography - Inductively Coupled Plasma MassSpectrometry (HPLC - ICP MS) 显示文摘 | Bierla K Szpunar J Lobinski R | 2008 | Anal Chim Acta2008，624，2： | 1 |
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