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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | A genetic linkage map for cattle 显示文摘 | Bishop M D Kappes S M | 1994 | Genetics1994，136，： | 1 |
| 3 | State anxiety modulation of the amygdala response to unattended threat-related stimuli显示文摘 | Bishop S Duncan J Lawrence AD | 2004 | J Neurosci2004，24，10： | 1 |
| 4 | Cuff integrity after arthroscopic versus open rotator cuff repair:a prospective study显示文摘 | Bishop J Klepps S Lo IK | 2006 | J Shoulder Elbow Surg2006，15，3： | 1 |
| 5 | The glucose metabolism of patients with malignant disease and of normal subjects as studied by means of an intravenous glucose tolerance test显示文摘 | MARKS P A BISHOP J S | 1957 | J Clin Invest1957，36，： | 1 |
| 6 | Identifica- tion of polymorphisms in the malic enzyme 1, NADP (+)-dependent, cytosolic and nuclear receptor sub- family 0, group B, member 2 genes and their associa- tions with meat and carcass quality traits in commercial Angus cattle显示文摘 | Gill J L Bishop S C McCorquodale C | 2012 | Anim Genet2012，43，： | 1 |
| 7 | Activities of three digestive enzymes during development in the crayfish Procambarus clarkii (Decapoda) 显示文摘 | Hammer H S Bishop C D Watts S A | 2000 | J Crustac Biol2000，20，： | 1 |
| 8 | Concurrent analy- sis of nose and groin swab specimens by the IDI-MRSA PCR assay is comparable to analysis by individual-specimen PCR and routine culture assays for detection of colonization by methicillin-resistant Staphylococcus aureus 显示文摘 | BISHOP E J GRABSCH S A BALLARD B M | 2006 | J Clin Microbio12006，44，8： | 1 |
| 9 | Reconfigurable implementation of wavelet integer lifting transforms for image compression显示文摘 | Bishop S L Rai S Gunturk B | 2006 | IEEE Transactions on Image Processing2006，4，5： | 1 |
| 10 | The onset of chaotic motions of a moored semi-submersible显示文摘 | Bishop S R Virgin L N | 1988 | Journal of OMAE1988，110，： | 1 |
| 11 | Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage显示文摘 | HORNER A BISHOP NJ BORD S | 1999 | J Anat1999，194，4： | 1 |
| 12 | Early clinical experience with a new videolaryngoscope (GlideScope) in 728 patients显示文摘 | Cooper R M Pacey J A Bishop M J McCluskey S A | 2005 | Can J Anaesth2005，52，： | 1 |
| 13 | Subacute digoxintoxicosis in the Beagle Dog显示文摘 | Teske R H Bishop S P Righter H F | 1976 | Toxicology and Applied Phar-macology1976，35，： | 1 |
| 14 | Mid-IR focal plane array based on type-ⅡIn As/Ga Sb strain layer superlattice detector with n Bn design显示文摘 | Kim H S Plis E Bishop G D | 2008 | Applied Physics Letters2008，92，： | 1 |
| 15 | Pharmacist and physician views on col- laborative practice: Findings from the community pharmaceutical care pro- ject显示文摘 | Kelly DV Bishop L Young S | 2013 | CPJ/RPC2013，146，4： | 1 |
| 16 | Homozygosityfor a single base-pair mutation in the oocyte-specificGDF9 gene results in sterility in Thoka sheep显示文摘 | Nicol L Bishop S C Pong-Wong R | 2009 | Repro-duction2009，138，6： | 1 |
| 17 | A dominant mutant allele of the ING4tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis显示文摘 | Kim S Welm A L Bishop J M | 2010 | Cancer Res2010，70，12： | 1 |
| 18 | Annum healthcare spending attributable to cigarette smoking: an update显示文摘 | XIN X U ELLEN E BISHOP S | 2015 | Am J Prey Med2015，48，3： | 1 |
| 19 | Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation:a comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research 显示文摘 | Bishop MR Logan BR Gandham S | 2008 | Bone Marrow Transplant2008，41，7： | 1 |
| 20 | Human induced loading on flexible staircases 显示文摘 | Kerr S C Bishop N W M | 2001 | Engineering Structures2001，23，1： | 1 |
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