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| 1 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 2 | Long-term resuits of laparoscopic adjustable gastric banding in patients lost to follow-up 显示文摘 | te Riele WW Boerma D Wiezer M J | 2010 | Br J Surg2010，97，10： | 1 |
| 3 | A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque de- velopment 显示文摘 | Boerma M Forsberg L Van Zeijl L | 1999 | J Intern Med1999，246，2： | 1 |
| 4 | Genotype effects on pro-liferative embryogenesis and plant regeneration of soybean显示文摘 | Bailey M A Boerma H R Parrott W A | 1993 | InVitro Cellular & Developmental Biology-Plant1993，29，： | 1 |
| 5 | Molecular mapping and confirmation of QTLs associated with oleic acid content in N003350 soybean显示文摘 | Monteros M J Burton J W Boerma H R | 2008 | Crop Science2008，48，： | 1 |
| 6 | Effects of nitroglycerin on sublingual mieroeircu --latory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-- blind randomized placebo controlled trial显示文摘 | Boerma E C Koopmans M Konijn A | 2010 | Crit Care Med2010，38，1： | 1 |
| 7 | Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-eoen- zyme A reductase inhibition 显示文摘 | Boerma M Burton GR Wang J | 2006 | Blood Coagul Fibrinolysis2006，17，3： | 1 |
| 8 | The Netherlands:Health system review显示文摘 | Sch fer W Kroneman M Boerma W van den Berg M Westert G Devill é W and van Ginneken E | | 0，，01： | 1 |
| 9 | Experimental radiation-induced heart disease: Past, present, and future 显示文摘 | Boerma M | 2012 | Radiation research2012，178，1： | 1 |
| 10 | Management and outcome of patients with established coronary artery disease: the Euro Heart Survey on coronary revascularization显示文摘 | Lezen M J Boerma E Bertrand M E | 2005 | Eur Heart J2005，26，12： | 1 |
| 11 | A QTL that enhances and broadens Bt insect resistance in soybean显示文摘 | Walker D R Narvel J M Boerma H R | 2004 | Theor App Genet2004，109，： | 1 |
| 12 | A major QTL conditioning salt tolerance in S-100 soybean and descendant cultivars显示文摘 | Lee G J Boerma H R Villagarcia M R | 2004 | TAG2004，109，： | 1 |
| 13 | A major QTL condi- tioning salt tolerance in S-100 soybean and descendent cultivars 显示文摘 | Lee G J Boerma H R Villagarcia M R | 2004 | Theoretical and Applied Genetics2004，109，8： | 1 |
| 14 | Inheritance of tumeformation in response to Agrobacterium tumefaciens soybean显示文摘 | Bailey M A Boerma H R Parrott W A | 1994 | Crop Sci1994，34，： | 1 |
| 15 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/ septic shock after a strict resuscitation protocol : A double-blind random- ized placebo controlled trial 显示文摘 | Boerma EC Koopmans M Konijn A | 2010 | Critical Care Med2010，38，1： | 1 |
| 16 | Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation显示文摘 | BOERMA M KRUSE J J VAN LOENEN M | 2004 | Strahlenther Onkol2004，180，： | 1 |
| 17 | Soybean quantitative trait loci and marker assisted breeding显示文摘 | Boerma H R Mian M A | 1999 | Proceedings of the World Soybean Research Conference1999，，6： | 1 |
| 18 | Radiation damage to the gastrointestinal tract:mechanisms,diagnosis,and management显示文摘 | Hauer-Jensen M Wang J Boerma M | | 0，，01： | 1 |
| 19 | Separation of neonatal rat ventricular myocytes and non-myocytes by centrifugal elutriation 显示文摘 | Boerma M van der Wees C G Wondergem J | 2002 | Pflugers Arch2002，444，3： | 1 |
| 20 | Microarray analysis of gene expression profiles of cardiac myocytes and fibroblasts after mechanical stress,ionising or ultraviolet radiation显示文摘 | BOERMA M VAN DER WEES C G VRIELING H | | 0，，： | 1 |
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