|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | 查看详情显示文摘 | Tao N G Liu H G Bolognesi C R | | 0，，： | 1 |
| 3 | In vitro and in vivoproperties of an anti-CD5-momordin immunotoxin on normal andneoplastic T lymphocytes显示文摘 | PORRO G BOLOGNESI A CARETTO P | 1993 | Cancer Immunol Immunother1993，36，5： | 1 |
| 4 | The allosteric regulation of pyruvate kinase显示文摘 | Mattevi A Bolognesi M Valentini G | 1996 | FEBS Lett1996，389，1： | 1 |
| 5 | Arterioportal fistulas in patients with liver cirrhosis:usefulness of color Doppler US for screening显示文摘 | Bolognesi M Sacerdoti D Bombonato G | 2000 | Radiology2000，216，3： | 1 |
| 6 | Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different Antag onism toward α1-Adrenoreceptor subtypes 显示文摘 | Bolognesi M L Marucci G | 2001 | J Med Chem2001，44，： | 1 |
| 7 | Vascular remodeling and duration of hypertension predict outcome of adrenalectomy in primary aldosteronism patients显示文摘 | ROSSI G P BOLOGNESI M RIZZONI D | | 0，，05： | 1 |
| 8 | High photoluminescence efficiency in substituted polythiophene aggregates显示文摘 | Bolognesi A Schieroni A G Botta C | 2003 | Synthetic Metals2003，139，2： | 1 |
| 9 | Genotoxicity of Pesticides: Potential Risk for Consumers显示文摘 | Bolognesi C Morasso G | 2000 | Trends in Food Science &Technology2000，11，5： | 1 |
| 10 | Digital holographic tracking of microprobes for multipoint viscosity measurements显示文摘 | G Bolognesi S Bianchi R Di Leonardo | 2011 | Opt Express2011，19，19： | 1 |
| 11 | Real-time digital holographic microscopy of multiple and arbitrarily oriented planes 显示文摘 | CAVALLINI L BOLOGNESI G LEONARDO R D | 2011 | Optics Letters2011，36，17： | 1 |
| 12 | Different cytotoxin activity and intracellular fate of an anti-CD5- monordinimmunotoxin in normal compared to tumor cells 显示文摘 | G Porro A Bolognesi P Careno | 1993 | Cancer Immunol Immunother1993，36，： | 1 |
| 13 | Arterioportal fistulas in patient with liver cirrhosis:usefulness of color Doppler US for screening显示文摘 | Bolognesi M Sacerdoti D Bombonato G | 2000 | Radiology2000，216，3： | 1 |
| 14 | Different cytotoxic activity and intracellular fate of an anti-CD5-momordin immunotoxin in normal compared to tumor cells 显示文摘 | Porro G Bolognesi A Caretto P | 1993 | Cancer Immunol Immunother1993，36，： | 1 |
| 15 | Toxicity of ribosome inactivating proteins-containing immuntoxins to a human bladder carcinoma cell line显示文摘 | Battelli M G Polito L Bolognesi A | 1996 | Int J Cancer1996，65，： | 1 |
| 16 | Polarized electroluminescence from an oriented poly (3-alkylthiophene) Langmuir-Biodgett structure 显示文摘 | Gajo G Paloheimo J | 1997 | Adv Mater1997，9，： | 1 |
| 17 | In vitro and in vivo properties of an anti-CD5 -momordin immunotoxin on normal and neoplastic T lymphocytes显示文摘 | Porro G Bolognesi A Caretto P | 1993 | Cancer Immunology Immunotherapy1993，36，5： | 1 |
| 18 | Change in portal flow after liver transplantation:effect on hepatic arterial resistance indices and role of spleen size显示文摘 | Bolognesi M Sacerdoti D Bombonato G | 2002 | Hepatology2002，35，3： | 1 |
| 19 | Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size显示文摘 | Bolognesi M Sacerdoti D Bombonato G | 2002 | Hepatology2002，35，3： | 1 |
| 20 | High photoluminescence efficiency in substituted polythiophene aggregates 显示文摘 | Bolognesi A Schieroni A G Botta C | 2003 | Synthetic Metals2003，139，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员