|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 4 | Black carbon affects the cycling of non-blackcarbon in soil显示文摘 | Liang BQ Lehmann J Sohi SP Thies JE Neill BO Trujillo L Gaunt J Solomon D Groossman J Neves EG Luizao FJ | 2010 | Organic Geochemistry2010，41，2： | 1 |
| 5 | Migration of phthalates from plastic products to model solutions显示文摘 | Bonir J Puntaric'D kes I | 2003 | Collegium Antropologicum2003，27，1： | 1 |
| 6 | Biological criteria for bufferzones around wetlands and riparian habitats for am-phibians and reptiles 显示文摘 | Semlitsch R D Bo die J R | 2003 | Conservation Biology2003，17，5： | 1 |
| 7 | On the first passage times of reflected O-U processes with two-sided barriers显示文摘 | Bo L J Zhang L D Wang Y J | 2006 | Queueing Systems2006，54，4： | 1 |
| 8 | Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8virus infection:a descriptive study显示文摘 | Chen H Yuan H Gao R Zhang J Wang D Xiong Y Fan G Yang F Li X Zhou J Zou S Yang L Chen T Dong L Bo H Zhao X Zhang Y Lan Y Bai T Dong J Li Q Wang S Zhang Y Li H Gong T Shi Y Ni X Li J Zhou J Fan J Wu J Zhou X Hu M Wan J Yang W Li D Wu G Feng Z Gao GF Wang Y Jin Q Liu M Shu Y | 2014 | Lancet2014，383，： | 1 |
| 9 | Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups显示文摘 | Scherag A Dina C Hinney A Vatin V Scherag S Vogel C I Muller T D Grallert H Wichmann H E Balkau B Heude B Jarvelin M R Hartikainen A L Levy-Marchal C Weill J Delplanque J Korner A Kiess W Kovacs P Rayner N W Prokopenko I McCarthy M I Schafer H Jarick I Bo | | 0，，04： | 1 |
| 10 | Crystallization kinetics of InF3 based glass by differential scanning calorimetry显示文摘 | Zhu J Bo Z Dong D | 1996 | J Non-Cryst Solids1996，，201： | 1 |
| 11 | Effects of oxygen and water va- por on volatile organic compounds decomposition using gliding arc gas显示文摘 | BO Z YAN J H LI X D | 2007 | Plasma Chemistry and Plasma Processing2007，27，5： | 1 |
| 12 | Discrepant clinicopathologic characteristics and HE4 performance in type I and type II epithelial ovarian cancer显示文摘 | Jiang J Bo D Chang X | 2015 | Int J Clin Exp Med2015，8，21： | 1 |
| 13 | Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis显示文摘 | Bo D Abe J Wei H | 2005 | Circulation2005，111，： | 1 |
| 14 | On the first passage times of reflected O-U processes with two-sided barriers显示文摘 | Bo L J Zhang L D Wang Y J | 2006 | Queueing Systems2006，54，4： | 1 |
| 15 | Scale-up analysis and development of gliding arc discharge facility for volatile organic compounds decom- position显示文摘 | Bo Z Yan J H Li X D | 2008 | Journal of Hazardous Materials2008，155，3： | 1 |
| 16 | Biological variations of leukocyte numerical and morphologic parameters de- termined by UniOel DxH 800 hematology analyzer 显示文摘 | Tang H Jing J Bo D | 2012 | Arch Pathol Lab Med2012，136，11： | 1 |
| 17 | Aeromonas hydrophila induces intestinal inflammation in grass carp (Ctenopharyn- godon ideUa): An experimental model 显示文摘 | Song X H Zhao J Bo Y X et d | 2014 | Aquaculture2014，434，： | 1 |
| 18 | Promoting survival, migration, and integration of transplanted Schwann cells by over-expressing polysialic acid 显示文摘 | Luo J Bo X Wu D | 2011 | Gila2011，59，3： | 1 |
| 19 | Plasma assisted dry methane reforming using gliding arc gas discharge: effect of feed gases proportion显示文摘 | Bo Z Yan J H Li X D | 2008 | In- ternational Journal of Hydrogen Energy2008，33，20： | 1 |
| 20 | Plasma assisted dry methane reforming using gliding arc gas discharge: effect of feed gases proportion 显示文摘 | Bo Z Yan J H Li X D Chi Y Cen K F | 2008 | Internation Journal of Hydrogen Energy2008，33，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员