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| 1 | 促生长激素分泌素受体基因多态性与肥胖关系显示文摘目的 了解促生长激素分泌素受体 (GHSR)基因多态性与青少年肥胖的关系。方法 选择 184名重度肥胖和 184名低体重青少年 ,对GHSR基因两个单核苷酸多态性 (SNP)进行快速高通量基因型分析。另对 2 70例肥胖、4 9例低体重和 96例体重正常者 ,进行其中 1个单核苷酸的基因多态性 (编号rs4 95 2 2 5 )检测 ,并对 387个肥胖核心家系进行传递 /不平衡检验 (TDT)。结果 在rs4 95 2 2 5多态性位点上 ,肥胖组的 171T等位基因频率 ( 75 0 % )明显高于低体重组 ( 70 2 % ) ,进一步扩大样本的关联分析显示相似趋势 ,但组间均无显著性差异。 387个核心家系中 171等位基因传递率为 5 1 8% ,略高于 171C等位基因 ( 4 8 2 % ) ,亦无显著性差异 (P =0 5 3)。结论 该人群中未发现促生长激素分泌素受体基因 | 王海俊 季成叶 Johannes Hebebrand Anke Hinney | 2004 | 中国公共卫生2004，20，9： | 2 |
| 2 | Several mutatuions in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans显示文摘 | Hinney A Schmidt A Nottebom K | 1999 | J Clin Endocrinol Metab1999，84，4： | 1 |
| 3 | The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts 显示文摘 | Lyon HN Emilsson V Hinney A | 2007 | PLoS Genet2007，3，4： | 1 |
| 4 | Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘 | Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J | | 0，，12： | 1 |
| 5 | Genes and lifestyle factors in obesity:Results from 12462 subjects from MONICA/KORA显示文摘 | Holzapfel C Grallert H Huth C Wahl S Fischer B Doring A Ruckert I M Hinney A Hebebrand J Wichmann H E Hauner H Illig T and Heid I M | | 0，，10： | 1 |
| 6 | Eating disorders:the current status of molecular genetic research 显示文摘 | Scherags S Hebebrand J Hinney A | 2010 | Eur Child Adolesc Psychiatry2010，19，3： | 1 |
| 7 | Independent confirmation of a major locus for obesity on chromosome 10 显示文摘 | Hinney A Ziegler A Oeffner F | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 8 | Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups显示文摘 | Scherag A Dina C Hinney A Vatin V Scherag S Vogel C I Muller T D Grallert H Wichmann H E Balkau B Heude B Jarvelin M R Hartikainen A L Levy-Marchal C Weill J Delplanque J Korner A Kiess W Kovacs P Rayner N W Prokopenko I McCarthy M I Schafer H Jarick I Bo | | 0，，04： | 1 |
| 9 | A Common Genetic Variant Is Associated with Adult and Childhood Obesity显示文摘 | HERBERT A COLDITZ G HINNEY A | 2006 | Science2006，312，5771： | 1 |
| 10 | In creased constraints on MC4R during primate and hu man evolution 显示文摘 | HUGHES D A HINNEY A BRUMM H | 2009 | Hum Genet2009，124，6： | 1 |
| 11 | Polygenic obesity in humans显示文摘 | Hinney A Hebebrand J | 2008 | Obesity Facts2008，1，1： | 1 |
| 12 | 'Fat mass and obesity associated' gene (FTO):No significant association for variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents 显示文摘 | Muller TD Hinney A Scherag A | 2008 | BMC Med Genet2008，9，17： | 1 |
| 13 | No impact of obesitysusceptibility loci on weight regain after a lifestyle interven-tion in overweight children 显示文摘 | Hinney A Wolters B Putter C | 2013 | J Pediatr EndocrinolMetab2013，26，1112： | 1 |
| 14 | Two new Loci for body- weight regulation identified in a joint analysis of genome-wide association studies forearly-onset extreme obesity in French and german study groups显示文摘 | Seherag A Dina C Hinney A | 2010 | PLoS Genet2010，6，： | 1 |
| 15 | Melanocortin-4 receptor gene:case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity显示文摘 | Hinney A Hohmann S Geller F | 2003 | J Clin Endocrinol Metab2003，88，9： | 1 |
| 16 | Eating disorders: the cur- rent status of molecular genetic research 显示文摘 | Scherag S Hebebrand J Hinney A | 2010 | Eur Child Adolese Psychiatry2010，19，3： | 1 |
| 17 | Aggravating effect of INSIG2 and FrO on overweight reduction in a one-year lifestyle interventi- on显示文摘 | Reinehr T Hinney A Toschke AM | 2009 | Arch Dis Child2009，94，12： | 1 |
| 18 | Development of a real-time,TaqMan reverse transcription PCR assay for detection and differentiation of Lyssavirus genotypes 1,5 ,and 6显示文摘 | Wakeley P R Johns on N Mc El hinney L M | 2005 | J Clin Microbiol2005，43，6： | 1 |
| 19 | Successful treat- ment with atomoxefine of an adolescent boy with atten- tion deficit/hyperactivity disorder, extreme obesity, and reduced melanocortin 4 receptor function 显示文摘 | Pott W Albayrak O Hinney A | 2013 | Obes Facts2013，6，1： | 1 |
| 20 | Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans显示文摘 | Schmidt A Nottebom K | 1999 | J Clin Endocrinol Metab1999，84，4： | 1 |
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