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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Evolutionarily conserved mammalian ade- nine nueleotide translocase 4 is essential for spermatogenesis显示文摘 | Brower JV Rodic N Seki T | 2007 | J Biol Chem2007，282，29： | 1 |
| 3 | Investigation of the effect of host composition on the photoluminescence properties of SrxBa1-x doped with Eu and Sm显示文摘 | BROWER D T LLOYD I K | 1995 | Journal of Material Research1995，10，1： | 1 |
| 4 | Effect of transforming growth factor beta-l on chondrogenic differentiation of culture equine mesenchymal stem cells显示文摘 | Worster AA Nixon A J Brower T | | 0，，09： | 1 |
| 5 | Coronaryartery atherosclerosis : Severity of the disease, severityof angina pectoris and compromised left ventricular function 显示文摘 | Leaman D M Brower R W Meester G T | 1981 | Circulation1981，63，2： | 1 |
| 6 | Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer显示文摘 | BROWER T BUTTERFIELD CE KRALING BM | 2000 | Cancer Res2000，60，： | 1 |
| 7 | Global trends in antimicrobial use in food animals 显示文摘 | Van Boeckel T P Brower C Gilbert M | 2015 | Proc Natl Acad Sci USA2015，112，18： | 1 |
| 8 | Intercellular cormnunication between granulose ceils and mouse oocytes: existence and possible nutritional role during oocyte growth 显示文摘 | Brower P T Schulta R M | 1982 | Dev Biol1982，90，： | 1 |
| 9 | Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance 显示文摘 | BOEHM T FOLKMAN J BROWER T | 1997 | Nature1997，390，： | 1 |
| 10 | Prognostic variables in invasive breast cancer, contribution of comedo versus non-comedo in-situ component 显示文摘 | Brower F T Ahmed S Tartter P | 1995 | Ann Surg Oncol1995，2，： | 1 |
| 11 | Oxygen in open-heath steel-oxidation during tapping and ladle filling 显示文摘 | Bain J W Larsan B M | 1950 | Trans AIME1950，188，6： | 1 |
| 12 | Prognostic variables in invasive breast cancer, contribution of comedo versus non comedoinsitu component 显示文摘 | Brower F T Ahmed S Tamer P | 1995 | Ann Surg Onco11995，2，： | 1 |
| 13 | Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis显示文摘 | Brower J V Rodic N Seki T | 2007 | J Biol Chem2007，282，29： | 1 |
| 14 | Chest wall resection for locally recurrent breast cancer Indication, technique and results显示文摘 | Steven T Brower | 1992 | J of Surg Oncol1992，49，2： | 1 |
| 15 | Coronary artery atherosclerosis:severity of the disease,severity of angina pectoris and compromised left ventricular function显示文摘 | Leaman D M Brower R W Meester G T | 1981 | Circulation1981，63，2： | 1 |
| 16 | The jones francture revisited显示文摘 | Kuanaugh T Brower T Mann T | 1978 | J Bone Joint Surg1978，，60： | 1 |
| 17 | Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer显示文摘 | Brower T Butterfield CE Kraling BM | 2000 | Cancer Res2000，60，： | 1 |
| 18 | Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload显示文摘 | Chancey A L Brower G L Peterson J T | 2002 | Circulation2002，105，： | 1 |
| 19 | Coronary artery atherosclerosis: severity of the disease, severity of angina pectoris and compromised left ventricular function显示文摘 | Leaman D M Brower R W Meester G T | 1981 | Circulation1981，63，2： | 1 |
| 20 | Effect of transforming growth factor beta1 on chondrogenic differentiation of cultured equine mesenchymal stem cells显示文摘 | Worster AA Nixon AJ Brower T | 2000 | Am J Vet Res2000，61，9： | 1 |
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