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| 1 | 欧洲呼吸学会和欧洲胸外科医师学会恶性胸膜间皮瘤诊疗指南显示文摘恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)是一种罕见肿瘤,但发病率正逐渐上升,且预后较差。2008年,欧洲呼吸学会(European Respiratory Society,ERS)和欧洲胸外科医师学会(European Society of Tho-racic Surgeons,ESTS)特别工作组召集各方专家计划制定MPM诊治经验及更新指南。为了使MPM得到及时准确的诊断,专家推荐对患者实施胸腔镜检查,有手术禁忌和胸腔粘连的病例除外。约10%的病例采用标准染色方法无法获得满意的结果。因此我们推荐在胸膜活检的基础上,采用特异性免疫组化标志物。由于目前缺乏一个统一的、切实有效的分期系统,我们推荐应用最新的TNM分期,并且提出三个阶段的治疗前评估。在MPM的治疗中,患者的体力状态评分和组织亚型是目前唯一的、具有重要临床价值的预后因素。在临床试验中,应对其它潜在因素进行初步探讨并予以报道。MPM对化疗高度耐受,仅有少数患者可接受根治性手术。本文对新的治疗方法和策略进行了综述。目前由于最佳综合治疗的资料有限,适合采用多种方案联合治疗策略的患者应被纳入专业机构的前瞻性试验中。 | A. Scherpereel P. Astoul P. Baas T. Berghmans H. Clayson P. de Vuyst H. Dienemann F. Galateau-Salle C. Hennequin G. Hillerdal C. Le Pe'choux L. Mutti J-C. Pairon R. Stahel P. van Houtte J. van Meerbeeck D. Waller W. Weder 宋作庆 徐萧洪 | 2010 | 中国肺癌杂志2010，，10： | 56 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | Current Trend in Synthesis,Post-Synthetic Modifications and Biological Applications of Nanometal-Organic Frameworks(NMOFs)显示文摘Since the early reports of MOFs and their interesting properties,research involving these materials has grown wide in scope and applications.Various synthetic approaches have ensued in view of obtaining materials with optimised properties,the extensive scope of application spanning from energy,gas sorption,catalysis biological applications has meant exponentially evolved over the years.The far-reaching synthetic and PSM approaches and porosity control possibilities have continued to serve as a motivation for research on these materials.With respect to the biological applications,MOFs have shown promise as good candidates in applicati ons involving drug delivery,BioMOFs,sensing,imaging amongst others.Despite being a while away from successful entry into the market,observed results in sensing,drug delivery,and imaging put these materials on the spot light as candidates poised to usher in a revolution in biology.In this regard,this review article focuses current approaches in synthesis,post functionalization and biological applications of these materials with particular attention on drug delivery,imaging,sensing and BioMOFs. | Ebenezer Baa Gary M.Watkins Rui.W.Krause Derek.N.Tantohb | 2019 | Chinese Journal of Chemistry2019，37，4： | 4 |
| 4 | Chemoradiation therapy in nonsmall cell lung cancer显示文摘 | Paul Baas Jose SA Belderbos Michel van den Heuvel | 2011 | Current Opinion in Oncology2011，，2： | 2 |
| 5 | Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery显示文摘 | A. Karliczek N. J. Harlaar C. J. Zeebregts T. Wiggers P. C. Baas G. M. Dam | 2009 | International Journal of Colorectal Disease2009，，5： | 2 |
| 6 | Surgeons lack predictive accuracy for anastomotic leakage in gastrointestinal surgery显示文摘 | A. Karliczek N. J. Harlaar C. J. Zeebregts T. Wiggers P. C. Baas G. M. Dam | 2009 | International Journal of Colorectal Disease2009，，5： | 2 |
| 7 | Chemoradiation therapy in non-small cell lung cancer显示文摘 | Baas P Belderbos JS van den H euvel M | 2011 | Curr Opin Oncol2011，23，2： | 1 |
| 8 | Photodynamic ther-apy: a promising new modality for the treatment of cancer显示文摘 | Schuitmaker J J Baas P van L H L | 1996 | JPhotochem Photobiol B1996，34，1： | 1 |
| 9 | Thoracoscopic ligation of a thoracic duct leakage 显示文摘 | Zoetmulder F Rutgers E Baas P | 1994 | Chest1994，106，： | 1 |
| 10 | Serum lev- els of brain-derived neurotrophic factor in major depres- sive disorder: state-trait issues, clinical features and phar- macological treatment显示文摘 | Molendijk ML Bus BAA Spinhoven PH | 2011 | Mol Psychiatry2011，16，11： | 1 |
| 11 | The effect of adding an equine bone matrix protein lyophilisate on fixation and os- seointegration of HA-coated Ti implants显示文摘 | Baas J Jakobsen T Elmengaard B | 2012 | J Biomed Mater Res A2012，100，1： | 1 |
| 12 | Long-term outcome of open or endovascular repair of abdominal aortic aneurysm显示文摘 | De Bruin JL Baas AF Buth J | | 0，，20： | 1 |
| 13 | p27kip1–838C>A Single Nucleotide Polymorphism Is Associated With Restenosis Risk After Coronary Stenting and Modulates p27kip1 Promoter Activity显示文摘 | Claudia M. van Tiel Peter I. Bonta Saskia Z.H. Rittersma Marcel A.M. Beijk Edward J. Bradley Anita M. Klous Karel T. Koch Frank Baas J Wouter Jukema Douwe Pons M Lourdes Sampietro Hans Pannekoek Robbert J. de Winter Carlie J.M. de Vries | 2009 | Circulation2009，，： | 1 |
| 14 | Activation of mitogen- activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells 显示文摘 | Rao GN Baas AS Glasgow WC | 1994 | J Biol Chem1994，269，32： | 1 |
| 15 | Personality and creativity: The dual pathway to creativity model and a research agenda显示文摘 | Baas M Roskes M Sligte D Nijstad B A and De Dreu C K W | 2013 | Social and Personality Psychology Compass2013，7，10： | 1 |
| 16 | Nivolumab versus Docetaxel in Advanced Squamous-Cell Non- Small-Cell Lung Cancer显示文摘 | Brahmer J Reckamp KL Baas P | 2015 | N Engl J Med2015，373，2： | 1 |
| 17 | An industrial ecology project in practice Exploring the boundaries of decision-making levels in regiona industrial systems 显示文摘 | Baas L W Boons F A | 2004 | Journal of Cleaner Production2004，12，810： | 1 |
| 18 | U ltrason ic root-endpreparation in apical surgery: a prospective randomized study显示文摘 | de Lange J Putters T Baas EM | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，104，4： | 1 |
| 19 | Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury显示文摘 | TANG - SCHOMER MD JOHNSON VE BAAS PW | 2012 | Exp Neurol2012，233，1： | 1 |
| 20 | Excessive bleeding in the floor of the mouth after endosseus implant placement:a report of two cases显示文摘 | Dubois L de Lange J Baas E | 2010 | Int J Oral Maxillofac Surg2010，39，4： | 1 |
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